海南睑虎繁殖生物学特征初步观察

关于睑虎属(Goniurosaurus)物种的研究主要集中在新种描述、分类分布以及系统进化等方面,繁殖生物学资料基本空白.本课题组于2017年9月至2019年8月对海南吊罗山国家级自然保护区内海南睑虎(G.hainanensis)的繁殖生物学特征进行了调查研究.结果发现,海南睑虎的繁殖期为3～10月,共观察到雌性个体1...     

Benzophenones from Guignardia sp. IFB‐E028, an Endophyte on Hopea hainanensis

The first natural S‐containing benzophenone dimer, named guignasulfide ( 3 ), was isolated from the culture of Guignardia sp. IFB‐E028, an endophytic fungus residing in healthy leaves of Hopea hainanensis. Its structure was determined through correlative analyses of its MS, 1D‐ and 2D‐NMR spectroscopic data. Two other known benzophenone derivatives, monomethylsulochrin and rhizoctonic acid ( 1 and 2 , resp.) were also isolated. Guignasulfide ( 3 ) was more active against the human liver cancer cell line HepG2 (IC₅₀ value: 5.2±0.4 μM ) than metabolites 1 and 2 (IC₅₀ values: 63.5±0.6 and 60.2±0.5 μM ); compounds 1 – 3 showed also moderately inhibitory effects on the human bacterial pathogen Helicobacter pylori with MIC values of 28.9±0.1, 60.2±0.4, and 42.9±0.5 μM , respectively.