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991.
Aqueous Solution‐Processable Small Molecular Metal‐Chelate Complex Electrolyte for Flexible All‐Solid State Energy Storage Devices 下载免费PDF全文
A small molecular metal‐chelate complex, tris(8‐hydroxyquinoline‐5‐sulfonic acid) aluminum (AlQSA3), that has three sulfonic acid groups per molecule leading to an excellent solubility in water is reported as a liquid‐free perfect solid‐state electrolyte for flexible film‐type all‐solid‐state energy storage devices. The AlQSA3 material is synthesized by one‐step reaction of aluminum triisopropoxide and 8‐hydroxyquinoline‐5‐sulfonic acid. The aqueous solutions of AlQSA3 are applied to fabricate flexible film‐type all‐solid state electric double layer capacitors with indium‐tin oxide thin film electrodes. The ion conductivity of the AlQSA3 film reaches 0.116 mS cm?1, while a pronounced hysteresis are obtained in the cyclic voltammetry measurement. The AlQSA3 film capacitors exhibit an output voltage of 1.5 V at 20 μA cm?2, which is considerably stable by the repeated operation. In particular, the peak output voltage is well kept even after 180° bending for 500 times in the case of the flexible AlQSA3 film capacitors. 相似文献
992.
993.
Lithium‐Ion Batteries: Excellent Compatibility of Solvate Ionic Liquids with Sulfide Solid Electrolytes: Toward Favorable Ionic Contacts in Bulk‐Type All‐Solid‐State Lithium‐Ion Batteries (Adv. Energy Mater. 22/2015) 下载免费PDF全文
994.
Da Qi Craig Lawless Johan Teleman Fredrik Levander Stephen W. Holman Simon Hubbard Andrew R. Jones 《Proteomics》2015,15(15):2592-2596
The mzQuantML data standard was designed to capture the output of quantitative software in proteomics, to support submissions to public repositories, development of visualization software and pipeline/modular approaches. The standard is designed around a common core that can be extended to support particular types of technique through the release of semantic rules that are checked by validation software. The first release of mzQuantML supported four quantitative proteomics techniques via four sets of semantic rules: (i) intensity‐based (MS1) label free, (ii) MS1 label‐based (such as SILAC or N15), (iii) MS2 tag‐based (iTRAQ or tandem mass tags), and (iv) spectral counting. We present an update to mzQuantML for supporting SRM techniques. The update includes representing the quantitative measurements, and associated meta‐data, for SRM transitions, the mechanism for inferring peptide‐level or protein‐level quantitative values, and support for both label‐based or label‐free SRM protocols, through the creation of semantic rules and controlled vocabulary terms. We have updated the specification document for mzQuantML (version 1.0.1) and the mzQuantML validator to ensure that consistent files are produced by different exporters. We also report the capabilities for production of mzQuantML files from popular SRM software packages, such as Skyline and Anubis. 相似文献
995.
996.
997.
Zi Feng Yang Chris Ka Pun Mok Xiao Qing Liu Xiao Bo Li Jian Feng He Wen Da Guan Yong Hao Xu Wei Qi Pan Li Yan Chen Yong Ping Lin Shi Guan Wu Si Hua Pan Ji Cheng Huang Guo Yun Ding Kui Zheng Chang Wen Ke Jin Yan Lin Yong Hui Zhang Horace Hok Yeung Lee Wen Kuan Liu Chun Guang Yang Rong Zhou Joseph Sriyal Malik Peiris Yi Min Li Rong Chang Chen Ling Chen Nan Shan Zhong 《PloS one》2015,10(2)
BackgroundThe second wave of avian influenza H7N9 virus outbreak in humans spread to the Guangdong province of China by August of 2013 and this virus is now endemic in poultry in this region.MethodsFive patients with H7N9 virus infection admitted to our hospital during August 2013 to February 2014 were intensively investigated. Viral load in the respiratory tract was determined by quantitative polymerase chain reaction (Q-PCR) and cytokine levels were measured by bead-based flow cytometery.ResultsFour patients survived and one died. Viral load in different clinical specimens was correlated with cytokine levels in plasma and broncho-alveolar fluid (BALF), therapeutic modalities used and clinical outcome. Intravenous zanamivir appeared to be better than peramivir as salvage therapy in patients who failed to respond to oseltamivir. Higher and more prolonged viral load was found in the sputum or endotracheal aspirates compared to throat swabs. Upregulation of proinflammatory cytokines IP-10, MCP-1, MIG, MIP-1α/β, IL-1β and IL-8 was found in the plasma and BALF samples. The levels of cytokines in the plasma and viral load were correlated with disease severity. Reactivation of herpes simplex virus type 1(HSV-1) was found in three out of five patients (60%).ConclusionExpectorated sputum or endotracheal aspirate specimens are preferable to throat swabs for detecting and monitoring H7N9 virus. Severity of the disease was correlated to the viral load in the respiratory tract as well as the extents of cytokinemia. Reactivation of HSV-1 may contribute to clinical outcome. 相似文献
998.
Bang Wool Eom Keun Won Ryu Byung-Ho Nam Yunjin Park Hyuk-Joon Lee Min Chan Kim Gyu Seok Cho Chan Young Kim Seung Wan Ryu Dong Woo Shin Woo Jin Hyung Jun Ho Lee 《PloS one》2015,10(2)
BackgroundA small number of nomograms have been previously developed to predict the individual survival of patients who undergo curative resection for gastric cancer. However, all were derived from single high-volume centers. The aim of this study was to develop and validate a nomogram for gastric cancer patients using a multicenter database.MethodsWe reviewed the clinicopathological and survival data of 2012 patients who underwent curative resection for gastric cancer between 2001 and 2006 at eight centers. Among these centers, six institutions were randomly assigned to the development set, and the other two centers were assigned to the validation set. Multivariate analysis using the Cox proportional hazard regression model was performed, and discrimination and calibration were evaluated by external validation.ResultsMultivariate analyses revealed that age, tumor size, lymphovascular invasion, depth of invasion, and metastatic lymph nodes were significant prognostic factors for overall survival. In the external validation, the concordance index was 0.831 (95% confidence interval, 0.784–0.878), and Hosmer-Lemeshow chi-square statistic was 3.92 (P = 0.917).ConclusionsWe developed and validated a nomogram to predict 5-year overall survival after curative resection for gastric cancer based on a multicenter database. This nomogram can be broadly applied even in general hospitals and is useful for counseling patients, and scheduling follow-up. 相似文献
999.
Jin Ock Kim Dong Woo Song Eun Jeong Kwon Seong-Eui Hong Hong Ki Song Choon Kee Min Do Han Kim 《PloS one》2015,10(3)
MicroRNA (miRNA) is an endogenous non-coding RNA species that either inhibits RNA translation or promotes degradation of target mRNAs. miRNAs often regulate cellular signaling by targeting multiple genes within the pathways. In the present study, using Gene Set Analysis, a useful bioinformatics tool to identify miRNAs with multiple target genes in the same pathways, we identified miR-185 as a key candidate regulator of cardiac hypertrophy. Using a mouse model, we found that miR-185 was significantly down-regulated in myocardial cells during cardiac hypertrophy induced by transverse aortic constriction. To confirm that miR-185 is an anti-hypertrophic miRNA, genetic manipulation studies such as overexpression and knock-down of miR-185 in neonatal rat ventricular myocytes were conducted. The results showed that up-regulation of miR-185 led to anti-hypertrophic effects, while down-regulation led to pro-hypertrophic effects, suggesting that miR-185 has an anti-hypertrophic role in the heart. Our study further identified Camk2d, Ncx1, and Nfatc3 as direct targets of miR-185. The activity of Nuclear Factor of Activated T-cell (NFAT) and calcium/calmodulin-dependent protein kinase II delta (CaMKIIδ) was negatively regulated by miR-185 as assessed by NFAT-luciferase activity and western blotting. The expression of phospho-phospholamban (Thr-17), a marker of CaMKIIδ activity, was also significantly reduced by miR-185. In conclusion, miR-185 effectively blocked cardiac hypertrophy signaling through multiple targets, rendering it a potential drug target for diseases such as heart failure. 相似文献
1000.
Yoon Hong Chun Kyungdo Han Yong-Gyu Park Jong-seo Yoon Hyun Hee Kim Jin Tack Kim Dae Chul Jeong 《PloS one》2015,10(4)