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101.
MENG Yan ZHOU Xueyan LI Yang ZHAO Dan LIANG Shuyuan ZHAO Xuejian YANG Baoxue . Department of Pathophysiology School of Medical Science Jilin University Changchun China . The Third Hospital of Jilin University Changchun China . Departments of Medicine University of California San Francisco CA - USA 《中国科学:生命科学英文版》2005,48(6):636-640
Jk (kidd) blood group antigens are carried by the urea transporter UT-B[1,2]. The Jknull phenotype, lack-ing urea permeability in erythrocytes[3,4], has a very low frequency in all populations except Polynesians and Finns[5]. In Japan, only 14 individuals with Jk (a-b-) phenotype were identified from 638460 screened donor’s blood samples using the 2 mol/L urea solution hemolysis test[6]. The frequency of Jknull is 0.27% in Polynesian, about 0.03% in Finland[7], and extremely rare in Fran… 相似文献
102.
The effects of proteasome inhibitor lactacystin on mouse oocyte meiosis and first cleavage 总被引:1,自引:0,他引:1
TAN Xin PENG An WANG Yongchao & TANG Zuoqing . School of Life Sciences Technology Beijing Institute of Technology Beijing China . College of Life Sciences Beijing Normal University Beijing China . College of Basic Medicine Capital University of Medical Sciences Beijing China 《中国科学:生命科学英文版》2005,48(3):287-294
Many studies have shown that the ubiq-uitin-proteasome pathway (UPP) for the degradation of short-lived proteins plays a key role in regulating cell cycle progression[1—3]. At least two distinct prote-olytic pathways are required for cell cycle process. The first pathway promotes transition from G1 to S phase, and the second initiates the onset of anaphase and exit from mitosis. The inhibition of UPP will re-sult in the blockage of cell cycle process. The knowl-edge of the role of UPP in… 相似文献
103.
SUN Xiangqing * JIA Yanbin * ZHANG Xuegong XU Qi SHEN Yan & LI Yanda . Ministry of Education 《中国科学:生命科学英文版》2005,48(3):263-269
Schizophrenia is a serious neuropsychiatric illness affecting about 1% of the world’s population. Family, twin and adoption studies have demonstrated that 65%―85% of the susceptibility to schizophrenia can be attributed to genes. On the basis of genetic model-ing of epidemiological data and recent results of a number of whole-genome screens for susceptibility genes, schizophrenia has been considered a complex disorder. A number of genes with small to moderate effects are involved in combinat… 相似文献
104.
CHEN Ruijuan JIANG Jiangang XIAO Xiao & WANG Daowen . The Institute of Hypertension Department of Internal Medicine Tongji Hospital Tongji Medical College Huazhong University of Science & Technology Wuhan China . Departments of Molecular Genetics Biochemistry & Gene Therapy Center University of Pittsburgh Pittsburgh PA USA 《中国科学:生命科学英文版》2005,48(5):495-505
Vascular endothelial cells play crucial roles in regulating cardiovascular function, maintaining car-diovascular homeostasis and preventing the occur-rence of cardiac and cerebral vascular diseases. All these protective effects are fulfilled through various vasoactive products secreted by endothelium including nitric oxide (NO), prostacyclin (PGI2) and endothe-lium-derived hyperpolarizing factor (EDHF). NO, pro-duced from L-arginine by endothelial nitric-oxide synthase (eNOS), is an impor… 相似文献
105.
REN Yuanyuan DAI Xiuyu ZHOU Jian LIU Jingfang PEI Huadong & XIANG Hua . State Key Laboratory of Microbial Resources Center for Molecular Microbiology Institute of Microbiology Chinese Academy of Sciences Beijing China . Graduate School of Chinese Academy of Sciences Beijing China 《中国科学:生命科学英文版》2005,48(3):221-227
Trehalose is a non-reducing disaccharide of glucosewidely distributed in microorganisms, plants and in-sects. It usually functions as a compatible solute in thestabilization of biological structures under several en-vironment stresses[1,2]. Trehalose has proved to be anactive stabilizer of enzymes, proteins, biomasses, pharmaceutical preparations and even organs fortransplantation. Thus much attention has been paid tothe synthesis pathway of trehalose and the develop-ment of novel and economic… 相似文献
106.
Tyroserleutide tripeptide affects calcium homeostasis of human hepatocarcinoma BEL-7402 cells 总被引:1,自引:0,他引:1
FU Zheng LU Rong LI Guoli ZHAO Lan GAO Weizhen CHE Xuchun JIAN Xu ZHOU Chunlei & YAO Zhi . Department of Immunology Tianjin Medical University Tianjin China . Shenzhen Kangzhe Pharmaceutical Co. Ltd. Shenzhen China . Department of Pharmacy Tianjin Medical University Tianjin China . Central Laboratory of Tianjin Medical University Hospital Tianjin China 《中国科学:生命科学英文版》2005,48(5):523-530
Copyright by Science in China Press 2005 Primary hepatocarcinoma is one of the most fre-quent digestive-tract cancers, particularly in China. The incidence and death rate of primary hepatocarci-noma in China is the highest in the world, with about 1100 thousands people dying from primary hepatocar-cinoma per year[1]. Although the chemotherapeutic agents are the main therapeutic approach for hepato- carcinoma, they are relatively ineffective and result in many toxic and side effects. Accordin… 相似文献
107.
Comparative analysis of the pig BAC sequence involved in the regulation of myostatin gene 总被引:2,自引:2,他引:0
YU Zhengquan LI Yan MENG Qingyong YUAN Jing ZHAO Zhihui LI Wei HU Xiaoxiang YAN Bingxue FAN Baoliang YU Shuyang & LI Ning .State Key Laboratory for Agrobiotechnology China Agricultural University Beijing China .Beijing Genomics Institute / Genomics Bioinformatics Center Institute of Genetics Development Biology Chinese Academy of Sciences Beijing China 《中国科学:生命科学英文版》2005,48(2):168-180
Myostatin (GDF-8, MSTN) is a member of trans- forming growth factors (TGF-β) superfamily, which was first described by McPherron et al. in 1997[1]. Myostatin appears to act as a negative regulator of muscle development and controls not only fibre size but also fibre number[2,3]. Mutations in the third exon of the myostatin gene have been shown to cause dou- ble muscling in cattle[4]. By knocking out the gene of myostatin in mice, they were able to show that the transgenic mice developed … 相似文献
108.
国产球盖蕨科植物管状分子的比较研究 总被引:1,自引:1,他引:0
利用扫描电镜观察了国产球盖蕨科10种植物,鳞毛蕨科6种植物的管状分子,结果显示:它们的管状分子端壁和侧壁的形态及结构分别相同,且侧壁具有穿孔板。它们具有4种类型的管状分子:(1)梯状穿孔板,无穿孔板的二型性现象;(2)梯状穿孔板,具有二型性现象;(3)梯状-网状混合穿孔板;(4)大孔状穿孔板。穿孔板仅存在于端壁的管状分子为导管分子,而端壁和侧壁形态、结构相似,有或无穿孔板的管状分子为管胞,蕨类植物中的管状分子主要为管胞,这与传统观点不同。管状分子的形态特征表明:球盖蕨科是鳞毛蕨群的成员,但不是原始成员,可能属于其中较为进化的类群,与鳞毛蕨科有许多共同特征,但仍存在较大差异,所以将其作为独立的科是合理的,推测球盖蕨科中的鱼鳞蕨属是比较进化的属,柄盖蕨属相对原始,红腺蕨属的系统位置应介于二者之间。 相似文献
109.
氮、磷、钾营养对冬小麦光合作用及水分利用的影响 总被引:8,自引:0,他引:8
在中国科学院封丘农业生态实验站长期肥料实验的基础上,选择氮磷(T1)、氮钾(T2)、磷钾(T3)和氮磷钾(T4)4个肥料处理,以不施肥为对照(CK),研究了长期施用氮、磷、钾肥对小麦抽穗期和灌浆期净光合速率(Pn)、蒸腾速率(Tr)和水分利用效率(WUE)日变化的影响.结果表明:小麦抽穗期和灌浆期T4处理的Pn日变化值显著高于CK,其他处理与CK未达到显著性差异,各处理Pn日积累量大小为T4>T1>T2>T3>CK;缺氮、缺磷和缺钾均降低了叶片Pn,影响大小依次为缺氮>缺磷>缺钾;小麦抽穗期和灌浆期Tr日变化曲线呈单峰型,处理间日变化值差异不显著;缺氮、缺磷和缺钾均降低了叶片WUE,抽穗期,T1、T4处理的WUE日变化值显著高于CK,而T3、T2与CK差异不显著,说明缺氮、缺磷对WUE的影响最大,灌浆期,T4处理的WUE日变化值显著高于CK;不同肥料处理仅改变了小麦光合日变化的幅度,而未改变其变化规律,氮、磷、钾复合施肥有效地提高了小麦的光合生产和水分利用效率. 相似文献
110.
将已构建好的表达载体pGEX-4T-2SAK 转化大肠杆菌E.coli BL21(DE3),经IPTG诱导表达融合的沙蚕激酶蛋白,通过GST树脂亲和吸附和凝血酶酶切及冷冻干燥等步骤进行分离纯化,用SDS-PAGE分析要重组的目的蛋白及纯化后的蛋白.纯化后的沙蚕激酶经纤维平板法测定具有溶栓活性.冷冻干燥品经SDS-PAGE分析表明达到电泳纯. 相似文献