高职院校中专学生SCL-90评定结果分析

目的:分析影响高职院校中专学生的心理健康状况的相关因素.方法:对抽取的江苏省某职业院校437名学生,用症状自评量表(SCL-90)调查,以因子分≥3筛查阳性个体进行检出率及年级差异的比较.结果:低年级学生SCL-909个因子得分均高于全国常模值,比较差异均有统计学意义(P＜0.05).心理健康阳性检出率的排序,其中排在前3位的分别为敌对、人际关系敏感以及强迫症状,它们的阳性检出率分别为6.86％、5.95％和5.03％,高于其他因子,比较差异均有统计学意义(P＜0.05).2009级学生的阳性率高于2010级,但心理健康阳性检出率年级差异无统计学意义(P＞0.05).结论:高职院校的中专学生心理健康状况不容乐观,敌对、人际关系敏感、强迫症状、抑郁、焦虑是其面临的主要心理问题,学校应该针对性的开展心理干预措施.     

急诊科护士心理健康状况调查研究

目的了解急诊科护士心理健康状况,为进一步采取心理干预提供依据。方法对贵港市人民医院急诊科护士和普通内科护士采用标准化问卷方式进行调查。结果 80名急诊科护士躯体化、强迫、人际关系、抑郁、焦虑、敌对、恐怖、偏执、精神病性9个因子评分均显著高于常模;急诊科护士人际关系、焦虑、敌对、偏执、精神病性5个因子评分高于普通内科护士。结论急诊护士心理健康状况较差,应当根据不同情况采取适当措施改善急诊护士的心理健康状况。     

抗震救灾中期军人心理压力源调查

目的:了解抗震救灾中期不同任务军人心理健康状况,探索军人心理压力源及对心理健康的影响.方法:采用自编心理压力源问卷和症状自评量表(SCL-90)的躯体化、强迫症状、人际关系敏感、抑郁、焦虑等5项因子问卷,对两组救援部队各50人进行调查,比较两组间差异性,并进行相关分析.结果:两组在躯体化症状、强迫症状、人际关系敏感、焦虑及应激程度上存在显著性差异(P<0.05),在孤立、恐惧及危险上存在显著性差异(P<0.05);应激程度与倦怠和恐怖/危险的严重程度,成正相关(P<0.05).结论:救灾任务的性质和强度决定了参与人员的心理压力源,从而影响人员的应激反应程度.     

实习护生学历与心理健康状况相关性研究

目的：了解不同学历实习护生心理健康状况及存在的心理健康问题,分析其与学历之间的关系,为实施干预提供依据。方法：采用症状自评量表（SCL-90）,对100名不同学历实习护生进行问卷调查。结果：不同学历实习护生SCL-90量表测试所得强迫症状、抑郁、焦虑、恐惧等因子分均高于常模组具体得分,不同学历SCL-90量表测试所得抑郁、焦虑、敌对、恐惧精神病性等因子分有差异。结论：强迫症状、抑郁、焦虑、敌对是不同学历实习护生最主要的心理问题,研究生、本科学历实习护生更为严重,不同学历心理问题的严重程度不同。     

医学院新生心理健康调查与分析

目的:调查某医学院校大学新生的心理健康状况.方法:采用症状自评量表(SCL-90)对1282名新生进行调查.结果:各因子中有轻度心理问题的学生所占比例最高是48.7%,各因子中有明显心理问题的学生所占比例最高是6.8%;新生强迫、人际关系、抑郁、焦虑、敌对性、恐怖、偏执、精神病性因子分高于全国常模,差异存在统计学意义;女生抑郁、焦虑、恐怖因子分高于男生,城市学生恐怖和总分因子分高于农村学生.在性别和生源地上的差异有统计学意义.在抑郁、焦虑、敌对性、偏执、其它这6个因子,新生的满意、比较满意、不太满意、很不满意、无所谓的意愿之间比较存在统计学意义.结论:医学院新生存在不同程度的心理健康问题.高校应重视新生心理健康教育并有针对性的开展工作.     

耐多药肺结核患者心理健康状况调查及与应对方式、社会支持的相关性研究

摘要 目的：探讨耐多药肺结核患者心理健康状况的影响因素,分析其及与应对方式、社会支持的相关性。方法：选择2018年4月至2020年5月我院诊治的101例耐多药肺结核患者作为观察组,选择同期99例敏感肺结核患者作为对照组。两组均测评症状自评量表-90(SCL-90)评分、医学应对问卷(MCMQ)评分以及社会支持评定量表(SSRS)评分,分析SCL-90总评分与MCMQ各因子评分、SSRS总评分的相关性,采用Logistic回归模型分析心理健康状况的影响因素。结果：与对照组相比,观察组的躯体化、人际关系、抑郁、焦虑、敌对性、恐怖和精神病性评分以及总评分明显提高（P<0.05）。与对照组相比,观察组的面对评分、客观支持、主观支持、支持利用度评分以及总评分均降低（P<0.05）。Pearson相关性分析显示,SCL-90总评分与MCMQ评分中的回避和屈服评分呈正相关性（r=0.386、0.311,均P<0.05）,SCL-90总评分与SSRS总评分呈负相关（r=-0.332,P<0.05）。多因素Logistic回归分析显示,经济状况差、躯体健康状况差、病情严重、睡眠质量差和生活满意度低是耐多药肺结核患者心理健康不良的独立危险因素（P<0.05）。结论：耐多药肺结核患者心理健康状况差,应对方式选择面对较少,总体社会支持水平较低,患者的心理健康状况与应对方式、社会支持存在一定的相关性。在提供躯体性治疗的基础上,应结合患者的心理健康状况及相关危险因素给予适当干预。     

4415名新兵心理健康状况调查分析

目的:了解4415名入伍新兵的心理健康状况,预防可能出现的应激性心理问题,并进一步对新兵进行筛选,为有针对性的进行心理健康教育提供科学依据.方法:应用卡特尔16种人格因素测验(16PF)对2011年入伍的4415名普通新兵进行心理测试.结果:入伍新兵在乐群性、聪慧性、稳定性、恃强性、兴奋性、有恒性、敢为性、世故性、自律性等因子上的得分高于常模,而在怀疑性、忧虑性、独立性、紧张性等因子上的得分低于常模;男女新兵在乐群性、恃强性、兴奋性、幻想性、自律性因子以及内向与外向型、感情用事与安详机警型、新环境成长能力三个次级因子上存在显著性差异;不同学历的新兵在聪慧性、稳定性、恃强性、兴奋性、有恒性、敢为性、幻想性、忧虑性、独立性因子以及适应与焦虑型、内向与外向型、怯懦与果断型、心理健康因素、专业成就个性因素、创造能力个性因素、新环境成长能力次级因子上存在显著差异.结论:2011年4415名新入伍战士整体上具有比较良好的心理品质;男女新兵在心理健康状况方面各有优劣;高学历新兵的心理健康状况优于低学历者.列出91名心理调节能力较差者,若干疑似精神病患者送往专业医院进行鉴定,最终对16名新兵做出退兵处理.     

大学生情绪智力与心理健康的关系

目的 了解大学生情绪智力与心理健康状况之间的关系,为大学生心理健康咨询与教育提供科学依据.方法 采用情绪智力量表(EIS)和症状自评量表(SCL-90),对整群随机抽取的太原市312名大学生进行问卷调查.结果 大学生人际敏感因子的城乡差异有统计学意义;SCL-90总分及各因子(除躯体化、焦虑、恐怖)的年级差异有统计学意义.大学生情绪智力总分与SCL-90总分及抑郁、恐怖、偏执、精神病性显著负相关,情绪自控能力与调控他人情绪能力与SCL-90总分及大部分因子显著负相关.除强迫、敌对外,不同情绪智力水平大学生SCL-90总分及各因子差异有统计学意义.情绪自控能力进入了大学生总体心理健康及各因子的回归模型中,情绪自控能力联合运用情绪能力能有效预测大学生总体心理健康及大部分因子.结论 自我调控能力和运用情绪能力是大学生心理健康的重要预测指标.     

成年女性压力性尿失禁患者心理健康状况调查分析

目的:探讨成年女性压力性尿失禁患者的心理健康状况,提出护理干预方法。方法:采用SCL-90及自编一般资料,对浏阳市市区80名有压力性尿失禁症状的成年女性进行心理健康自评调查,另80名无压力性尿失禁症状的成年女性为对照。结果:有压力性尿失禁症状的成年女性SCL-90总分、阳性项目数、阳性项目均分及躯体化、人际关系、抑郁、焦虑、敌对、恐怖和精神病性等因子评分均明显高于对照组及常模组(P<0.05)。结论:成年女性压力性尿失禁患者心理健康状况不容乐观,应引起重视,并对其进行护理干预,加强对她们的心理疏通,可以提高疾病的防治效果。     

广东大中学女教师心理健康状况调查研究

目的：调查研究广东大中学女教师心理健康状况并对两者进行比较。方法：利用症状自评量表（SCL-90）对广东330名女教师的心理健康状况进行问卷调查,同时访谈其中10位女教师。结果：大中学女教师的心理健康状况比全国普通人群差,具有轻度心理问题检出率为39．6％,明显心理问题检出率为18．3％;表现突出的是强迫症状、人际关系敏感、抑郁和焦虑。不同群体女教师的心理健康状况存在显著差异：中学女教师比大学女教师差;已婚女教师比未婚女教师差;35～45岁的女教师的心理健康问题较为严重。结论：女教师的心理健康状况不容乐观。建议从制度层面到人文关怀层面,从社会、学校到家庭都给予女教师更多的关心与爱护,客观上为女教师营造良好的生活环境和工作环境;主观上女教师应不断提高自身修养,学会调适自己心理,预防疾病,用正确积极的态度去应对生活和工作。     

A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus (2019-nCoV) Potentially Related to Viral Transmissibility

正Dear Editor,In December 2019, a novel human coronavirus caused an epidemic of severe pneumonia(Coronavirus Disease 2019,COVID-19) in Wuhan, Hubei, China(Wu et al. 2020; Zhu et al. 2020). So far, this virus has spread to all areas of China and even to other countries. The epidemic has caused 67,102 confirmed infections with 1526 fatal cases     

Curcuminoids as inhibitors of thioredoxin reductase: A receptor based pharmacophore study with distance mapping of the active site

Curcumin is the yellow pigment of turmeric that interacts irreversibly forming an adduct with thioredoxin reductase (TrxR), an enzyme responsible for redox control of cell and defence against oxidative stress. Docking at both the active sites of TrxR was performed to compare the potency of three naturally occurring curcuminoids, namely curcumin, demethoxy curcumin and bis-demethoxy curcumin. Results show that active sites of TrxR occur at the junction of E and F chains. Volume and area of both cavities is predicted. It has been concluded by distance mapping of the most active conformations that Se atom of catalytic residue SeCYS498, is at a distance of 3.56 from C13 of demethoxy curcumin at the E chain active site, whereas C13 carbon atom forms adduct with Se atom of SeCys 498. We report that at least one methoxy group in curcuminoids is necessary for interation with catalytic residues of thioredoxin. Pharmacophore of both active sites of the TrxR receptor for curcumin and demethoxy curcumin molecules has been drawn and proposed for design and synthesis of most probable potent antiproliferative synthetic drugs.     

Comparative morphology of the carpel in the Liliaceae: Hewardieae, Petrosavieae, and Tricyrteae

The young pistils in the melanthioid tribes, Hewardieae, Petrosavieae and Tricyrteae, are uniformly tricarpellate and syncarpous. They lack raphide idioblasts. All are multiovulate, with bitegmic ovules. The Petrosavieae are marked by the presence of septal glands and incomplete syncarpy. Tepals and stamens adhere to the ovary in the Hewardieae and the Petrosavieae but not in the Tricyrteae. Two vascular bundles occur in the stamens of the Hewartlieae and Tricyrtis latifolia. Ventral bundles in the upper part of the ovary of the Hewardieae are continuous with compound septal bundles and placental bundles in the lower part. Putative ventral bundles occur in the alternate position in the Tricyrteae and putative placental bundles in the opposite. position in the Petrosavieae. The dichtomously branched stigma in each carpel of the Tricyrteae is supplied by a bifurcated dorsal bundle.     

Enterovirus 71 3C proteolytically processes the histone H3 N-terminal tail during infection

Highlights
1. The N-terminal tail of histone H3 is specifically cleaved during EV71 infection.
2. Viral protease 3C is identified as a protease responsible for proteolytically processing the N-terminal H3 tail.
3. Our finding reveals a new epigenetic regulatory mechanism for Enterovirus 71 in virus-host interactions.     

Detection of EBV and HHV6 in the Brain Tissue of Patients with Rasmussen’s Encephalitis

Rasmussen’s encephalitis (RE) is a rare pediatric neurological disorder, and the exact etiology is not clear. Viral infection may be involved in the pathogenesis of RE, but conflicting results have reported. In this study, we evaluated the expression of both Epstein-Barr virus (EBV) and human herpes virus (HHV) 6 antigens in brain sections from 30 patients with RE and 16 control individuals by immunohistochemistry. In the RE group, EBV and HHV6 antigens were detected in 56.7% (17/30) and 50% (15/30) of individuals, respectively. In contrast, no detectable EBV and HHV6 antigen expression was found in brain tissues of the control group. The co-expression of EBV and HHV6 was detected in 20.0% (6/30) of individuals. In particular, a 4-year-old boy had a typical clinical course, including a medical history of viral encephalitis, intractable epilepsy, and hemispheric atrophy. The co-expression of EBV and HHV6 was detected in neurons and astrocytes in the brain tissue, accompanied by a high frequency of CD8⁺ T cells. Our results suggest that EBV and HHV6 infection and the activation of CD8⁺ T cells are involved in the pathogenesis of RE.     

Perinatal Vertical Transmission of Chikungunya Virus in Ruili,a Town on the Border between China and Myanmar

正Dear Editor,Chikungunya virus (CHIKV), an arbovirus in the family of Togaviridae, genus Alphavirus, is transmitted by the A.aegyptii or A. albopictus mosquito, and causes disease in humans characterized by fever, rash, and arthralgia (Silva and Dermody 2017; Suhrbier 2019). It was first reported in 1953 in Tanzania, and caused only a few outbreaks and sporadic cases in Africa and Asia in last century. However, in the epidemic in 2004, CHIKV acquired mutations that conferred enhanced transmission by the A. albopictus mosquito(Schuffenecker et al. 2006). Since then, it has successively caused outbreaks in Africa, the Indian Ocean, South East Asia, the South America, and Europe (Zeller et al. 2016).     

Development of a Novel Reverse Transcription Loop-Mediated Isothermal Amplification Method for Rapid Detection of SARS-CoV-2

In conclusion, the novel visual RT-LAMP assay is a simple, rapid, and sensitive approach for detection of SARS-CoV-2, and it is ready for application in primary care and community hospitals or health care centers, and even patients' own houses in response to the current SARS-CoV-2 epidemic because the assay does not require sophisticated equipment and skilled personnel. Furthermore, it is also ready to be used in fields for screening samples from wild animals and environments to facilitate the identification of potential intermediate hosts that mediate the cross-species transmission of SARS-CoV-2 from bats to humans.