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1.
云木香化学成分研究Ⅱ 总被引:2,自引:1,他引:1
从丽江产云木香(SausrealappaC.B.Clarke)根中分离得到的另外7个化合物,它们分别是_孕甾烯醇酮(pregnenolone)(1),β-谷甾醇(β-sitosterol)(2),葫萝卜甙(daucosterol)(3),苯丙素甙(syringin)(4),木质素甙(1-hydroxypinoresinol-1-β-D-glucopyranoside)(5),油酸[(z,z)-9,12-octadecadienoicacid](6)和油酸-1,3-甘油二酯[(z,z)-9,12-octadecadienoicacid-2-hydroxy-1,3-propanedinylester](7).它们的结构通过波谱和化学的方法得到鉴定。其中化合物1作为天然产物首次从植物中分离得到,化合物3,4,5和7为首次从该植物中分离得到。 相似文献
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云南永善产蜘蛛抱蛋的甾体成分 总被引:3,自引:0,他引:3
从云南省永善县产的百合科植物蜘蛛抱蛋(Aspidistra elatior)根状茎中分离得到8个甾体化合物。其中6个为已知的甾体化合物,分别鉴定为(25S)-3β-hydroxy-spirost-5-ene 3-O-β-D-glucopyranosyl(1→)「β-D-xylopyranosyl(1→3)」-β-D-glucopyranosyl(1→4)-β-D-galactopyranoside 相似文献
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宝兴卫矛甾体成分研究 总被引:8,自引:0,他引:8
从宝兴卫矛(Euonymus mupinensis Loes et Rehd)中分离得到6个化合物,分别鉴定为:豆甾-4-烯-3,6-二酮(1),stigmastane-3β,6α-diol(2),stigmastane-3β,5,6α-triol(3),3β-hydroxy-5α,8α-epidiocyergosta-6E,22E-diene(4),β-谷甾醇(5),胡萝卜甙(6),化合物1 ̄4 相似文献
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云木香化学成分研究 II 总被引:7,自引:0,他引:7
从丽江产云木香(SaussrealappaC.B.Clarke)根中分离得到的另外7化合物,它们分别是孕甾炮醇酮(pregnenolone)(1),β-谷甾醇(β-sitosterol)(2)葫萝卜甙(daucosterol)(3),苯丙素甙(syringin)(4),木质素甙(1-hydroxypinoresinol-1-β-D-glucopyranoside)(5)油酸(z,z)-9,12-o 相似文献
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1植物名称王瓜(Trichosanthescuc-umeroides),采自浙江天目山。2材料类别顶芽、带腋芽的茎段。3培养条件诱导分化培养基:(1)MS+6-BA0.5mg·L-1(单位下同);(2)MS+6-BA1;(3)MS+6.BA2+2,4-D1。诱导生根与生长培养基:(4)MS;(5)MS+IAA2;(6)MS+6-BA1+2,4-D1。每种培养基均附加3%蔗糖,0,7%琼脂,pH5.8。培养温度(25±1)℃,光照每天12h,光照度20001x左右。4生长与分化情况4.1无菌材料的… 相似文献
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用丙型肝炎病毒重组蛋白C33_c抗原免疫BALB/c小鼠,运用杂交瘤技术成功地建立了7株能稳定分泌抗C33_c单克隆抗体的杂交瘤细胞1H6D2、2G1A6、3A4A8、3E3E7、4G12C10、4A10C2、5F4B6.试验结果表明,7株McAbs具有良好的HCV特异性,间接ELISA法测得小鼠腹水McAb效价为1:10 ̄4-1:4×10 ̄4;竞争抑制实验和相加指数测定证实7株McAbs识别相关的抗原表位;7株McAbs中1株为IgM(5F4B6),其它6株为IgG(2a)。 相似文献
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从乌药(Lindera aggrwegata(Sims)Kosterm)根的镇痛、抗火活性组分(LEF)中分离得到6个缩合鞣质烃化合物,鉴定出其中4个,分别为表儿茶素(1)-epicatechin、表榈儿茶素(-)-epigallocatechin、procyanidinB-2及trimeric proanthocyanidin(cinnamtannins B1),另得到一个黄酮苷,鉴定为橙皮甙h 相似文献
10.
藏玄参中的抑精三萜皂甙 总被引:1,自引:0,他引:1
从藏药植物藏玄参(OreosolenwattiiHook.f.)的全草中分离到4个三萜皂甙,密蒙花甙(mimengoside)A和B及醉鱼草甙(buddlejasaponin)I和Ia,另外还得到阿克甙(acteoside)和6-羟基木犀草素-7-O-葡萄糖甙(6-hydroxyluteolin-7-O-glucoside)。体外抑精实验表明,4个三萜皂甙均有较强的抑精活性,其中密蒙花甙A和醉鱼草 相似文献
11.
正Dear Editor,In December 2019, a novel human coronavirus caused an epidemic of severe pneumonia(Coronavirus Disease 2019,COVID-19) in Wuhan, Hubei, China(Wu et al. 2020; Zhu et al. 2020). So far, this virus has spread to all areas of China and even to other countries. The epidemic has caused 67,102 confirmed infections with 1526 fatal cases 相似文献
12.
Curcumin is the yellow pigment of turmeric that interacts irreversibly forming an adduct with thioredoxin reductase (TrxR), an enzyme
responsible for redox control of cell and defence against oxidative stress. Docking at both the active sites of TrxR was performed to compare
the potency of three naturally occurring curcuminoids, namely curcumin, demethoxy curcumin and bis-demethoxy curcumin. Results show
that active sites of TrxR occur at the junction of E and F chains. Volume and area of both cavities is predicted. It has been concluded by
distance mapping of the most active conformations that Se atom of catalytic residue SeCYS498, is at a distance of 3.56 from C13 of
demethoxy curcumin at the E chain active site, whereas C13 carbon atom forms adduct with Se atom of SeCys 498. We report that at least
one methoxy group in curcuminoids is necessary for interation with catalytic residues of thioredoxin. Pharmacophore of both active sites of
the TrxR receptor for curcumin and demethoxy curcumin molecules has been drawn and proposed for design and synthesis of most probable
potent antiproliferative synthetic drugs. 相似文献
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The young pistils in the melanthioid tribes, Hewardieae, Petrosavieae and Tricyrteae, are uniformly tricarpellate and syncarpous. They lack raphide idioblasts. All are multiovulate, with bitegmic ovules. The Petrosavieae are marked by the presence of septal glands and incomplete syncarpy. Tepals and stamens adhere to the ovary in the Hewardieae and the Petrosavieae but not in the Tricyrteae. Two vascular bundles occur in the stamens of the Hewartlieae and Tricyrtis latifolia. Ventral bundles in the upper part of the ovary of the Hewardieae are continuous with compound septal bundles and placental bundles in the lower part. Putative ventral bundles occur in the alternate position in the Tricyrteae and putative placental bundles in the opposite. position in the Petrosavieae. The dichtomously branched stigma in each carpel of the Tricyrteae is supplied by a bifurcated dorsal bundle. 相似文献
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Meng Miao Gang Deng Xiaobei Xiong Yang Qiu Wenda Huang Meng Yuan Fei Yu Shimei Bai Xi Zhou Xiaolu Zhao 《中国病毒学》2022,37(2):314-317
Highlights
1. The N-terminal tail of histone H3 is specifically cleaved during EV71 infection.
2. Viral protease 3C is identified as a protease responsible for proteolytically processing the N-terminal H3 tail.
3. Our finding reveals a new epigenetic regulatory mechanism for Enterovirus 71 in virus-host interactions. 相似文献
1. The N-terminal tail of histone H3 is specifically cleaved during EV71 infection.
2. Viral protease 3C is identified as a protease responsible for proteolytically processing the N-terminal H3 tail.
3. Our finding reveals a new epigenetic regulatory mechanism for Enterovirus 71 in virus-host interactions. 相似文献
17.
Dong Liu Xin Wang Yisong Wang Peigang Wang Dongying Fan Sichang Chen Yuguang Guan Tianfu Li Jing An Guoming Luan 《中国病毒学》2018,33(5):402-409
Rasmussen’s encephalitis (RE) is a rare pediatric neurological disorder, and the exact etiology is not clear. Viral infection may be involved in the pathogenesis of RE, but conflicting results have reported. In this study, we evaluated the expression of both Epstein-Barr virus (EBV) and human herpes virus (HHV) 6 antigens in brain sections from 30 patients with RE and 16 control individuals by immunohistochemistry. In the RE group, EBV and HHV6 antigens were detected in 56.7% (17/30) and 50% (15/30) of individuals, respectively. In contrast, no detectable EBV and HHV6 antigen expression was found in brain tissues of the control group. The co-expression of EBV and HHV6 was detected in 20.0% (6/30) of individuals. In particular, a 4-year-old boy had a typical clinical course, including a medical history of viral encephalitis, intractable epilepsy, and hemispheric atrophy. The co-expression of EBV and HHV6 was detected in neurons and astrocytes in the brain tissue, accompanied by a high frequency of CD8+ T cells. Our results suggest that EBV and HHV6 infection and the activation of CD8+ T cells are involved in the pathogenesis of RE. 相似文献
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Shen Jia-Yuan Li Man Xie Lyu Mao Jia-Rong Zhou Hong-Ning Wang Pei-Gang Jiang Jin-Yong An Jing 《中国病毒学》2021,36(1):145-148
正Dear Editor,Chikungunya virus (CHIKV), an arbovirus in the family of Togaviridae, genus Alphavirus, is transmitted by the A.aegyptii or A. albopictus mosquito, and causes disease in humans characterized by fever, rash, and arthralgia (Silva and Dermody 2017; Suhrbier 2019). It was first reported in 1953 in Tanzania, and caused only a few outbreaks and sporadic cases in Africa and Asia in last century. However, in the epidemic in 2004, CHIKV acquired mutations that conferred enhanced transmission by the A. albopictus mosquito(Schuffenecker et al. 2006). Since then, it has successively caused outbreaks in Africa, the Indian Ocean, South East Asia, the South America, and Europe (Zeller et al. 2016). 相似文献
20.
Renfei Lu Xiuming Wu Zhenzhou Wan Yingxue Li Lulu Zuo Jianru Qin Xia Jin Chiyu Zhang 《中国病毒学》2020,35(3):344-347
In conclusion, the novel visual RT-LAMP assay is a simple, rapid, and sensitive approach for detection of SARS-CoV-2, and it is ready for application in primary care and community hospitals or health care centers, and even patients' own houses in response to the current SARS-CoV-2 epidemic because the assay does not require sophisticated equipment and skilled personnel. Furthermore, it is also ready to be used in fields for screening samples from wild animals and environments to facilitate the identification of potential intermediate hosts that mediate the cross-species transmission of SARS-CoV-2 from bats to humans. 相似文献