共查询到20条相似文献,搜索用时 46 毫秒
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HIV-1反式激活因子(Tat)作用机理的研究进展梁臣,耿运琪(南开大学生命科学学院,天津300071)关键词HIV-1,Tat,TAR人免疫缺陷病毒-1(HIV-1)属反转录病毒科,慢病毒亚科,为艾滋病的重要病原体。该病毒可长期潜伏于人体内,但在某... 相似文献
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艾滋病(AIDS)主要是由人免疫缺陷病毒(HIV)侵入人体后,破坏人的免疫系统造成的。许多流行病学研究已证明,疱疹病毒与HIV的共感染可以导致对HIV-1启动子的激活,并加速细胞的病理性反应〔1〕,从而加大个体对HIV感染的敏感和加快疾病的进程。人疱... 相似文献
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从HIV-Ⅰ中新发现编码含硒蛋白的基因探讨艾滋病化疗新方法刘琼,徐辉碧(华中理工大学化学系,武汉430074)关键词 艾滋病,人类免疫缺陷病毒Ⅰ型,硒艾滋病是一种目前尚无有效防治方法的疾病。它是由人类免疫缺陷病毒(HIV)感染,并在宿主细胞内大量复制... 相似文献
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广东两株人免疫缺陷病毒的分离和鉴定 总被引:1,自引:0,他引:1
从我省两名经性途径感染艾滋病的病人中采血,分离外周血单核细胞(PBMCs),将其与正常人PBMCs共培养分离人免疫缺陷病毒(HIV),3周后检测上清HIV-1p24抗原(ELISA法)超过阈值。将共培养第四周细胞和上清分别感染H9细胞(T细胞淋巴瘤传代细胞),一周后检测HIV-1 p24怕,证明有病毒生长。用HIV-1 ENV基因引物的套式聚合酶链反应(Nested PCR)证实,两株新分离的病毒 相似文献
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人免疫缺陷病毒HIV-1gag和env基因片段在大肠杆菌中的表达祁自柏,谷金莲,李河民(中国药品生物制品检定所,北京100050)由于引起艾滋病的HIV-1病毒的多变性,使得艾滋病的预防和治疗遇到很大困难。我们从一株用艾滋病人外周血淋巴细胞感染的细胞... 相似文献
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项秉懿 《Virologica Sinica》1996,(1)
HIV-1感染初始阶段的分子机制项秉懿(第四军医大学分子生物学研究所,西安710032)关键词艾滋病,人类免疫缺陷病毒-I型,包膜糖蛋白gp120,CD4受体,感染TheMolecularMechanismofHIV-1InfectionintheI... 相似文献
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人类免疫缺陷病毒细胞辅助受体的研究进展谭伟赵翠萍综述李德富审校(中国药品生物制品检定所,北京100050)分类号R511前言人类免疫缺陷病毒(Humanimmunodeficiencyvirus,HIV)可以在人类引起艾滋病(AIDS)。经过十几年的... 相似文献
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人获得性免疫缺陷综合症(AcquiredImmunodeficiencySyndrome,简称AIDS)主要是由人免疫缺陷病毒Ⅰ型(HIV1)引起的严重危害人类健康的传染病。HIV研究的最新进展揭示了膜糖蛋白gp120与其受体和中和抗体复合物晶体结... 相似文献
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Curcumin is the yellow pigment of turmeric that interacts irreversibly forming an adduct with thioredoxin reductase (TrxR), an enzyme
responsible for redox control of cell and defence against oxidative stress. Docking at both the active sites of TrxR was performed to compare
the potency of three naturally occurring curcuminoids, namely curcumin, demethoxy curcumin and bis-demethoxy curcumin. Results show
that active sites of TrxR occur at the junction of E and F chains. Volume and area of both cavities is predicted. It has been concluded by
distance mapping of the most active conformations that Se atom of catalytic residue SeCYS498, is at a distance of 3.56 from C13 of
demethoxy curcumin at the E chain active site, whereas C13 carbon atom forms adduct with Se atom of SeCys 498. We report that at least
one methoxy group in curcuminoids is necessary for interation with catalytic residues of thioredoxin. Pharmacophore of both active sites of
the TrxR receptor for curcumin and demethoxy curcumin molecules has been drawn and proposed for design and synthesis of most probable
potent antiproliferative synthetic drugs. 相似文献
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正Dear Editor,In December 2019, a novel human coronavirus caused an epidemic of severe pneumonia(Coronavirus Disease 2019,COVID-19) in Wuhan, Hubei, China(Wu et al. 2020; Zhu et al. 2020). So far, this virus has spread to all areas of China and even to other countries. The epidemic has caused 67,102 confirmed infections with 1526 fatal cases 相似文献
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The young pistils in the melanthioid tribes, Hewardieae, Petrosavieae and Tricyrteae, are uniformly tricarpellate and syncarpous. They lack raphide idioblasts. All are multiovulate, with bitegmic ovules. The Petrosavieae are marked by the presence of septal glands and incomplete syncarpy. Tepals and stamens adhere to the ovary in the Hewardieae and the Petrosavieae but not in the Tricyrteae. Two vascular bundles occur in the stamens of the Hewartlieae and Tricyrtis latifolia. Ventral bundles in the upper part of the ovary of the Hewardieae are continuous with compound septal bundles and placental bundles in the lower part. Putative ventral bundles occur in the alternate position in the Tricyrteae and putative placental bundles in the opposite. position in the Petrosavieae. The dichtomously branched stigma in each carpel of the Tricyrteae is supplied by a bifurcated dorsal bundle. 相似文献
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Michael Hesse 《Plant Systematics and Evolution》1980,134(3-4):229-267
Some closely related members of the monocotyledonous familiesAlismataceae, Liliaceae, Juncaceae, Cyperaceae, Poaceae andAraceae with variable modes of pollination (insect- and wind-pollination) were studied in relation to the ultrastructure of pollenkitt and exine (amount, consistency and distribution of pollenkitt on the surface of pollen grains). The character syndromes of pollen cementing in entomophilous, anemophilous and intermediate (ambophilous or amphiphilous) monocotyledons are the same in principal as in dicotyledons. Comparing present with former results one can summarize: 1) The pollenkitt is always produced in the same manner by the anther tapetum in all angiosperm sub-classes. 2) The variable stickiness of entomophilous and anemophilous pollen always depends on the particular distribution and consistency of the pollenkitt, but not its amount on the pollen surface. 3) The mostly dry and powdery pollen of anemophilous plants always contains a variable amount of inactive pollenkitt in its exine cavities. 4) A step-by step change of the pollen cementing syndrome can be observed from entomophily towards anemophily. 5) From the omnipresence of pollenkitt in all wind-pollinated angiosperms studied one can conclude that the ancestors of anemophilous angiosperms probably have been zoophilous (i.e. entomophilous) throughout. 相似文献
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Surveillance of Class Ⅰ Newcastle Disease Virus at Live Bird Markets and Commercial Poultry Farms in Eastern China Reveals the Epidemic Characteristics 下载免费PDF全文
Xiaolong Lu Xiaoquan Wang Tiansong Zhan Yifan Sun Xin Wang Naiqing Xu Tianxing Liao Yu Chen Min Gu Shunlin Hu Xiaowen Liu Xiufan Liu 《中国病毒学》2021,36(4):818-822
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正Dear Editor,Parainfluenza virus 5 (PIV5), known as canine parainfluenza virus in the veterinary field, is a negative-sense,nonsegmented, single-stranded RNA virus belonging to the Paramyxoviridae family (Chen 2018). The virus was first reported in primary monkey kidney cells in 1954 (Hsiung1972), then it has been frequently discovered in various 相似文献