蝮蛇抗栓酶,丹参注射液对高粘状态血液流变学影响的对比观察

本文应用蝮蛇抗栓酶(清栓酶)和丹参注射液对高血压、冠心病、脑动脉硬化并有高粘状态84例进行治疗,其中清栓酶组50例;丹参组34例。检测血球压积,全血比粘度、全血还原粘度、血浆比粘度、红细胞电泳、纤维蛋白原、血沉等7项血液流变学指标,并进行治疗前后对比观察。经统计学处理后发现抗栓酶组的治疗效果明显优于丹参组(P<0.005)。抗栓酶有大幅度降低纤维蛋白原的作用。所以蝮蛇抗栓酶是目前应用于血栓病。血液高粘滞血症HVS等病症较为理想的药物。     

蝮蛇抗栓酶对实验性矽肺治疗作用的研究

本文报告了蝮蛇抗栓酶对大鼠实验性矽肺的治疗有很好的疗效。其治疗机理为：通过染尘大鼠肺干重及全肺胶原蛋白测定其Ｔ／Ｃ值分别为０．６８和０．７１,其病理切片以１级为主。提示蝮蛇抗栓酶有抑制肺纤维化的作用,延缓矽肺的进展;通过用ＴＢＡ反应萤光比色法测定肺组织中丙二醛（ＭＤＡ）含量,结果表明：蝮蛇抗栓酶能显著地降低肺组织中ＭＤＡ含量（Ｐ＜０．０１）。提示蝮蛇抗栓酶具有体内抗氧化作用,提高体内ＳＯＤ水平,促进体内抗脂质过氧化的作用。抑制和减慢了肺组织原纤维化过程,从而起到抗胶原反应的作用。同时对抗了矽尘对肺组织损伤作用;通过测定染尘大鼠血液流变学中全血高切和低切粘度比,血浆粘度比、红细胞聚集指数和血沉等指标,均高于正常对照组,说明矽肺存在高粘滞血症,用蝮蛇抗栓酶治疗后其五项指标与矽肺对照组比较有显著性差异（Ｐ＜０．０５）提示蝮蛇抗栓酶有效地改变血液中的高粘滞状态,改善微循环,使矽肺病情得以缓解。     

蝮蛇抗栓酶降粘解聚的效用：附82例分析

收治年龄与病情类似的高粘滞血症(HVS)82例,随机分为三组,分别静脉滴注蝮蛇抗栓酶;复方丹参注射液和口服肠溶阿斯匹林加维脑路通.结果蝮蛇抗栓酶组具有明显的降粘、去纤作用,对红细胞电泳速度及高密度脂蛋白的提升作用亦非常显著(P<0.01).三组比较,蝮蛇抗栓酶的降粘解聚作用明显优于其它两组的疗效.且副作用轻,未发现肝肾功能损伤和出血现象.     

蝮蛇抗栓酶治疗高粘滞血症的血流变学研究（附47例分析）

本文报道采用蝮蛇抗栓酶治疗血液粘度异常以上的高粘滞血症４７例,以复方丹参对照观察,两组治疗１～２疗程后,复查血液粘度恢复正常者,抗栓酶治疗组占６８％,复方丹参治疗组占６０％;两种药物对降低全血粘度,血球压积,加快红细胞电泳均有明显作用;抗栓酶对降低纤维蛋白原和男性的全血粘度较复方丹参作用更显著,是治疗高粘滞血症一种较理想的药物,也可作为心脑缺血性血管疾病的预防治疗。     

蝮蛇抗栓酶与脑活素治疗高粘滞血症的疗效对比（摘要）

蝮蛇抗栓酶与脑活素治疗高粘滞血症的疗效对比（摘要）解放军运输工程学院门诊部郑盛群，任渝祥本文以蝮蛇抗栓酶治疗组２０例与脑活素对照组１８例，对高粘滞血症进行疗效对比报告如下：一、资料与方法随机抽样蝮蛇抗栓酶治疗组２０例中男１３例，女７例，平均年龄６２．...     

两种蝮蛇抗栓酶与传统方法治疗缺血性脑卒中146例的疗效分析

采用东北白眉蝮蛇抗栓酶、江浙蝮蛇抗栓酶、丹参加低右治疗缺血性脑卒中,以一般对症处理治疗作为对照组结果显示东北白屑蝮蛇抗栓酶治疗缺血性脑卒中与对照组比较 P 值有显著性差异,而其他两组与对照组比较 P 值无显著性差异.     

蝮蛇抗栓酶对高粘血症患者血液流变与微循环影响的观察

静注蝮蛇抗栓酶并口服青龙胶囊治疗高粘血症１４０例患者。结果显示,蝮蛇抗栓酶能明显降低血液粘度,表现为全血粘度、血浆粘度、全血还原粘度及纤维蛋白原降低,同时降低甲襞微循环形态、流态及管周状态积分。探讨其改善血液粘度机制。     

蛇毒清栓酶治疗突发性耳聋48例疗效报告

本文报告用清栓酶治疗突聋48例的疗效观察。其中男40例,女8例,总有效率为88％。文章指出,病程越短,疗效越好,强调早期诊断,早期治疗。清栓酶与低分子右旋糖酐组治疗突聋进行了对比。清栓酶的疗效明显优于后者。清栓酶治疗突聋的机理是通过药物去纤、降粘、解聚、溶栓、扩血管,改善微循环等作用而实现的。清栓酶为治疗突聋的一种新方法,此药治疗作用迅速。效果可靠,无明显毒副作用,值得推广使用。     

蝮蛇抗栓酶对肺心病急性加重期20例疗效观察（摘要）

蝮蛇抗栓酶对肺心病急性加重期２０例疗效观察（摘要）黑龙江省五常市人民医院林寿源在常规治疗的基础上,应用蝮蛇抗栓酶治疗肺心病急性加重期２０例并与对照组２０例进行疗效对比观察。结果表明,蝮蛇抗栓酶组控制呼吸道感染,心肺功能明显改善,平均需要５—７天,而对...     

清栓酶对高粘滞综合征的疗效观察：（附126例临床分析）

应用蝮蛇抗栓酶治疗高粘滞综合征126例。结果表明:显效71.7%,总有效率99.2%,说明清栓酶治疗高粘滞综合征是理想的药物     

A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus (2019-nCoV) Potentially Related to Viral Transmissibility

正Dear Editor,In December 2019, a novel human coronavirus caused an epidemic of severe pneumonia(Coronavirus Disease 2019,COVID-19) in Wuhan, Hubei, China(Wu et al. 2020; Zhu et al. 2020). So far, this virus has spread to all areas of China and even to other countries. The epidemic has caused 67,102 confirmed infections with 1526 fatal cases     

Curcuminoids as inhibitors of thioredoxin reductase: A receptor based pharmacophore study with distance mapping of the active site

Curcumin is the yellow pigment of turmeric that interacts irreversibly forming an adduct with thioredoxin reductase (TrxR), an enzyme responsible for redox control of cell and defence against oxidative stress. Docking at both the active sites of TrxR was performed to compare the potency of three naturally occurring curcuminoids, namely curcumin, demethoxy curcumin and bis-demethoxy curcumin. Results show that active sites of TrxR occur at the junction of E and F chains. Volume and area of both cavities is predicted. It has been concluded by distance mapping of the most active conformations that Se atom of catalytic residue SeCYS498, is at a distance of 3.56 from C13 of demethoxy curcumin at the E chain active site, whereas C13 carbon atom forms adduct with Se atom of SeCys 498. We report that at least one methoxy group in curcuminoids is necessary for interation with catalytic residues of thioredoxin. Pharmacophore of both active sites of the TrxR receptor for curcumin and demethoxy curcumin molecules has been drawn and proposed for design and synthesis of most probable potent antiproliferative synthetic drugs.     

Comparative morphology of the carpel in the Liliaceae: Hewardieae, Petrosavieae, and Tricyrteae

The young pistils in the melanthioid tribes, Hewardieae, Petrosavieae and Tricyrteae, are uniformly tricarpellate and syncarpous. They lack raphide idioblasts. All are multiovulate, with bitegmic ovules. The Petrosavieae are marked by the presence of septal glands and incomplete syncarpy. Tepals and stamens adhere to the ovary in the Hewardieae and the Petrosavieae but not in the Tricyrteae. Two vascular bundles occur in the stamens of the Hewartlieae and Tricyrtis latifolia. Ventral bundles in the upper part of the ovary of the Hewardieae are continuous with compound septal bundles and placental bundles in the lower part. Putative ventral bundles occur in the alternate position in the Tricyrteae and putative placental bundles in the opposite. position in the Petrosavieae. The dichtomously branched stigma in each carpel of the Tricyrteae is supplied by a bifurcated dorsal bundle.     

Enterovirus 71 3C proteolytically processes the histone H3 N-terminal tail during infection

Highlights
1. The N-terminal tail of histone H3 is specifically cleaved during EV71 infection.
2. Viral protease 3C is identified as a protease responsible for proteolytically processing the N-terminal H3 tail.
3. Our finding reveals a new epigenetic regulatory mechanism for Enterovirus 71 in virus-host interactions.     

Detection of EBV and HHV6 in the Brain Tissue of Patients with Rasmussen’s Encephalitis

Rasmussen’s encephalitis (RE) is a rare pediatric neurological disorder, and the exact etiology is not clear. Viral infection may be involved in the pathogenesis of RE, but conflicting results have reported. In this study, we evaluated the expression of both Epstein-Barr virus (EBV) and human herpes virus (HHV) 6 antigens in brain sections from 30 patients with RE and 16 control individuals by immunohistochemistry. In the RE group, EBV and HHV6 antigens were detected in 56.7% (17/30) and 50% (15/30) of individuals, respectively. In contrast, no detectable EBV and HHV6 antigen expression was found in brain tissues of the control group. The co-expression of EBV and HHV6 was detected in 20.0% (6/30) of individuals. In particular, a 4-year-old boy had a typical clinical course, including a medical history of viral encephalitis, intractable epilepsy, and hemispheric atrophy. The co-expression of EBV and HHV6 was detected in neurons and astrocytes in the brain tissue, accompanied by a high frequency of CD8⁺ T cells. Our results suggest that EBV and HHV6 infection and the activation of CD8⁺ T cells are involved in the pathogenesis of RE.     

Perinatal Vertical Transmission of Chikungunya Virus in Ruili,a Town on the Border between China and Myanmar

正Dear Editor,Chikungunya virus (CHIKV), an arbovirus in the family of Togaviridae, genus Alphavirus, is transmitted by the A.aegyptii or A. albopictus mosquito, and causes disease in humans characterized by fever, rash, and arthralgia (Silva and Dermody 2017; Suhrbier 2019). It was first reported in 1953 in Tanzania, and caused only a few outbreaks and sporadic cases in Africa and Asia in last century. However, in the epidemic in 2004, CHIKV acquired mutations that conferred enhanced transmission by the A. albopictus mosquito(Schuffenecker et al. 2006). Since then, it has successively caused outbreaks in Africa, the Indian Ocean, South East Asia, the South America, and Europe (Zeller et al. 2016).     

Development of a Novel Reverse Transcription Loop-Mediated Isothermal Amplification Method for Rapid Detection of SARS-CoV-2

In conclusion, the novel visual RT-LAMP assay is a simple, rapid, and sensitive approach for detection of SARS-CoV-2, and it is ready for application in primary care and community hospitals or health care centers, and even patients' own houses in response to the current SARS-CoV-2 epidemic because the assay does not require sophisticated equipment and skilled personnel. Furthermore, it is also ready to be used in fields for screening samples from wild animals and environments to facilitate the identification of potential intermediate hosts that mediate the cross-species transmission of SARS-CoV-2 from bats to humans.