维螨属一新种：蜱螨亚纲：革螨股

本文记述维螨属１新种：汤旺河维螨Ｖｅｉｇａｉａｔａｎｇｗａｎｇｈｅｎｓｉｓｓｐ．ｎｏｖ。     

宁夏毛绥螨属一新种：蜱螨亚纲：囊螨科

本文记述采自宁夏角川市郊柳树寄生多孔菌体上的毛绥螨属１新种－殷氏毛绥螨Ｌａｓｉｏｓｅｉｕｓ ｙｉｎｉ,ｓｐ．ｎｏｕ。,模式标本保存在宁夏回族自治区地方病防治所和沈阳农业大学。     

宁夏常革螨属一新种：蜱螨亚纲：寄螨科

本文记述常革螨属Ｖｕｌｇａｒｏｇａｍａｓｕｓ一新种,命名为海原常革螨Ｖｕｌｇａｒｏｇａｍａｓｕｓｈａｉｙｕａｎｅｎｓｉｓｓｐ．ｎｏｖ．模式标本采自宁夏海原县阿拉善黄鼠巢穴内,存于宁夏回族自治区地方病防治所。     

中国囊螨属一新种：蜱螨亚纲：囊螨科

本文记述囊螨属Asca V.Heyden的一个新种中华囊螨Asca sinica sp.nov.,其特征:前后背板刚毛除S_8外,其它均呈镰状或桨状;St_1位于胸板外,胸扳前缘与第1对隙孔近平直;生殖板之后具一长的小骨片;腹肛板前缘略凸,周肛毛6对,最后2对镰状。模式标本采自宁夏回族自治区海原县,蚂蚁Myrmos sp.洞道及巢穴内,保存于宁夏回族自治区地方病防治所。     

青海省阳厉螨属一新种：蜱螨亚纲：厉螨科

本文记述从青海省湟中长尾仓鼠Ｃｒｉｅｃｔｕｌｕｓ ｌｏｎｇｉｃａｕｄａｔｕｓ巢中采得的阳厉螨属一新种,即九棘阳厉螨Ａｎｄｒｏｌａｅｌａｐｓ ｎｏｖｅｍｓｐｉｎｏｓｕｓ ｓｐ．ｎｏｖ。新种与三叉阳厉螨Ａ．ｔｒｉｆｕｒｃａｔｕｓ Ｗａｎｇ ｅｔ ＬｉＲＵＶ ＲＰ     

鄂西北钝革螨属一新种：蜱螨亚纲：寄螨科

本文记述钝革螨属一新种,神农架钝革螨Ａｍｂｌｙｇａｍａｓｕｓ ｓｈｅｎｎｏｎｇｊｉａｅｎｓｉｓ ｓｐ．ｎｏｖ．采自湖北神农架的大林姬鼠,模式标本存湖北省医学科学院寄生虫病研究所媒介昆虫研究室。     

纤恙螨属恙螨一新种：蜱螨亚纲：恙螨科

从采自新疆博乐县阿拉山口(海拔290 m)室内灰仓鼠伏龙芝亚种 Cricetulus migratorius caesius耳壳内的一批纤恙螨标本鉴定中发现中国新记录亚属——爱柯纤恙螨亚属 Ericotrombidium中的一个新种,定名为博乐纤恙螨 Leptotrombidium (E.) bolei sp.nov.,它与美丽纤恙螨L.(E.)pulchrum(Sosnina,1950)及索氏纤恙螨L.(E.)sokolovi Kudryshova,1984比较近似,但本新种IP及盾板量度除 AM外均较大,PW-SB≥PL,可与前者区别;IP较小,平均787,幅度763—821,DS较少,排列规则:2+8.6.6.4.2=28,可与后者区别。     

A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus (2019-nCoV) Potentially Related to Viral Transmissibility

正Dear Editor,In December 2019, a novel human coronavirus caused an epidemic of severe pneumonia(Coronavirus Disease 2019,COVID-19) in Wuhan, Hubei, China(Wu et al. 2020; Zhu et al. 2020). So far, this virus has spread to all areas of China and even to other countries. The epidemic has caused 67,102 confirmed infections with 1526 fatal cases     

Curcuminoids as inhibitors of thioredoxin reductase: A receptor based pharmacophore study with distance mapping of the active site

Curcumin is the yellow pigment of turmeric that interacts irreversibly forming an adduct with thioredoxin reductase (TrxR), an enzyme responsible for redox control of cell and defence against oxidative stress. Docking at both the active sites of TrxR was performed to compare the potency of three naturally occurring curcuminoids, namely curcumin, demethoxy curcumin and bis-demethoxy curcumin. Results show that active sites of TrxR occur at the junction of E and F chains. Volume and area of both cavities is predicted. It has been concluded by distance mapping of the most active conformations that Se atom of catalytic residue SeCYS498, is at a distance of 3.56 from C13 of demethoxy curcumin at the E chain active site, whereas C13 carbon atom forms adduct with Se atom of SeCys 498. We report that at least one methoxy group in curcuminoids is necessary for interation with catalytic residues of thioredoxin. Pharmacophore of both active sites of the TrxR receptor for curcumin and demethoxy curcumin molecules has been drawn and proposed for design and synthesis of most probable potent antiproliferative synthetic drugs.     

Comparative morphology of the carpel in the Liliaceae: Hewardieae, Petrosavieae, and Tricyrteae

The young pistils in the melanthioid tribes, Hewardieae, Petrosavieae and Tricyrteae, are uniformly tricarpellate and syncarpous. They lack raphide idioblasts. All are multiovulate, with bitegmic ovules. The Petrosavieae are marked by the presence of septal glands and incomplete syncarpy. Tepals and stamens adhere to the ovary in the Hewardieae and the Petrosavieae but not in the Tricyrteae. Two vascular bundles occur in the stamens of the Hewartlieae and Tricyrtis latifolia. Ventral bundles in the upper part of the ovary of the Hewardieae are continuous with compound septal bundles and placental bundles in the lower part. Putative ventral bundles occur in the alternate position in the Tricyrteae and putative placental bundles in the opposite. position in the Petrosavieae. The dichtomously branched stigma in each carpel of the Tricyrteae is supplied by a bifurcated dorsal bundle.     

Enterovirus 71 3C proteolytically processes the histone H3 N-terminal tail during infection

Highlights
1. The N-terminal tail of histone H3 is specifically cleaved during EV71 infection.
2. Viral protease 3C is identified as a protease responsible for proteolytically processing the N-terminal H3 tail.
3. Our finding reveals a new epigenetic regulatory mechanism for Enterovirus 71 in virus-host interactions.     

Detection of EBV and HHV6 in the Brain Tissue of Patients with Rasmussen’s Encephalitis

Rasmussen’s encephalitis (RE) is a rare pediatric neurological disorder, and the exact etiology is not clear. Viral infection may be involved in the pathogenesis of RE, but conflicting results have reported. In this study, we evaluated the expression of both Epstein-Barr virus (EBV) and human herpes virus (HHV) 6 antigens in brain sections from 30 patients with RE and 16 control individuals by immunohistochemistry. In the RE group, EBV and HHV6 antigens were detected in 56.7% (17/30) and 50% (15/30) of individuals, respectively. In contrast, no detectable EBV and HHV6 antigen expression was found in brain tissues of the control group. The co-expression of EBV and HHV6 was detected in 20.0% (6/30) of individuals. In particular, a 4-year-old boy had a typical clinical course, including a medical history of viral encephalitis, intractable epilepsy, and hemispheric atrophy. The co-expression of EBV and HHV6 was detected in neurons and astrocytes in the brain tissue, accompanied by a high frequency of CD8⁺ T cells. Our results suggest that EBV and HHV6 infection and the activation of CD8⁺ T cells are involved in the pathogenesis of RE.     

Perinatal Vertical Transmission of Chikungunya Virus in Ruili,a Town on the Border between China and Myanmar

正Dear Editor,Chikungunya virus (CHIKV), an arbovirus in the family of Togaviridae, genus Alphavirus, is transmitted by the A.aegyptii or A. albopictus mosquito, and causes disease in humans characterized by fever, rash, and arthralgia (Silva and Dermody 2017; Suhrbier 2019). It was first reported in 1953 in Tanzania, and caused only a few outbreaks and sporadic cases in Africa and Asia in last century. However, in the epidemic in 2004, CHIKV acquired mutations that conferred enhanced transmission by the A. albopictus mosquito(Schuffenecker et al. 2006). Since then, it has successively caused outbreaks in Africa, the Indian Ocean, South East Asia, the South America, and Europe (Zeller et al. 2016).     

Development of a Novel Reverse Transcription Loop-Mediated Isothermal Amplification Method for Rapid Detection of SARS-CoV-2

In conclusion, the novel visual RT-LAMP assay is a simple, rapid, and sensitive approach for detection of SARS-CoV-2, and it is ready for application in primary care and community hospitals or health care centers, and even patients' own houses in response to the current SARS-CoV-2 epidemic because the assay does not require sophisticated equipment and skilled personnel. Furthermore, it is also ready to be used in fields for screening samples from wild animals and environments to facilitate the identification of potential intermediate hosts that mediate the cross-species transmission of SARS-CoV-2 from bats to humans.