Special Issue on‘‘Computational Cardiology’’

<正>We are pleased to announce a special issue on‘‘Computational Cardiology’’of the journal Genomics,ProteomicsBioinformatics(GPB),aiming to provide a platform for high-quality papers focusing on the topic and we invite submissions for this special issue(to be published in the fall of 2015).Dr.Benjamin Meder(University of Heidelberg and German Center for Cardiovascular Research–DZHK     

Special Issue on‘‘Biomarkers for Diseases’’

<正>The journal Genomics ProteomicsBioinformatics(GPB)is now inviting submissions for a special issue(to be published in the winter of 2015)on the topic of‘‘Biomarkers for Diseases’’.As an emerging index,disease biomarkers have demonstrated the potential application in diagnosis and prognosis.The detection of the disease indicators at molecular level,DNA,RNA     

‘Ins’ and ‘outs’ of triple therapy

Chronic oral anticoagulant treatment is obligatory in patients (class I) with mechanical heart valves and in patients with atrial fibrillation with CHADS2 score >1. When these patients undergo percutaneous coronary intervention with placement of a stent, there is also an indication for treatment with aspirin and clopidogrel. Unfortunately, triple therapy is known to increase the bleeding risk. For this group of patients, the bottom line is to find the ideal therapy in patients with indications for both chronic anticoagulation therapy and percutaneous intervention to prevent thromboembolic complications such as stent thrombosis without increasing the risk of bleeding. (Neth Heart J 2010;18:444-50.)     

Reading Wacquant as both ‘lumper’ and ‘splitter’

In this short response to Loïc Wacquant's ‘Marginality, Ethnicity and Penality in the Neo-liberal City’, I outline two intellectual conversations that emerge from the author's work. The first develops out of the connections that the author draws between systems of criminal justice and welfare. The second grows out of the disassociation he urges us to see between the logics and trajectories of crime, on the one hand, and criminal justice on the other. I then briefly describe how my own work has been influenced by and contributes to these two ongoing streams of research.     

‘Classical’ and ‘non-classical’ reproductive steroids in fish

Summary The nature of the steroids secreted by gonads of fish differs significantly from those of the mammals. The classical teleost steroids, oestradiol, testosterone, 11-ketotestosterone and 17,20P, have been measured in a wide variety of teleosts but do not always reflect biological activities. There is increasing evidence that teleost gonads may produce a number of non-classical steroids which may play an important role in their reproductive biology. Such products include metabolites reduced at C5 to 5 or 5, at C3 to 3 or 3, or hydroxylated at 6-, 7-, or 21. Conjugation, as either glucuronides or sulphates, may contribute either to localization of action within the gonad or to production of pheromones during the immediate pre-spawning period. Although it is often possible only to measure the steroids for which assays are readily available, it is important to recognize that there may be production of steroids that are not detected by such assays, but which nevertheless play a major role in reproductive activity. In evolutionary terms, the teleost hydroxylases probably originated in the very early fishes and show parallels with their analogues in amphibians and mammals. Gene sequencing may reveal a possible common ancestor for all vertebrate 6, 7 and 11-hydroxylases.     

Special Issue on‘‘Metagenomics of Marine Environments’’

<正>We are pleased to announce a special issue on‘‘Metagenomics of Marine Environments’’of the journal Genomics,ProteomicsBioinformatics(GPB),aiming to provide a platform for high-quality papers focusing on the topic and we invite submissions for this special issue(to be published in the fall of 2015).With most microbes being difficult or impossible to culture     

扬‘课改’之帆 建‘高效’课堂

随着社会的不断发展和进步,基础教育课程改革的不断推进和深化,教师在数学教学中不仅仅要教授学生必须的基础知识和基本技能,还要培养学生的创新精神和实践能力,这样才能培养出优秀的栋梁之材。所以大多数数学教师也充分认识到了探究教学的优势,探究教学可以使学生充分发挥学生的思维和数学能力,也能使教学任务顺利并且有效的完成。     

Defining ‘Life’

There is no broadly accepted definition of life. Suggested definitions face problems, often in theform of robust counter-examples. Here we use insights fromphilosophical investigations into language to argue thatdefining `life' currently poses a dilemma analogous to thatfaced by those hoping to define `water' before the existenceof molecular theory. In the absence of an analogous theoryof the nature of living systems, interminable controversyover the definition of life is inescapable.     

‘Cosmopolitan Baku’

Among the many points of reflection in looking back on the last 100 years in the Caucasus, a particular pride of place for some Azerbaijanis comes in the status of Baku as a cosmopolitan city: a status claimed by historians who speak of the early twentieth-century border crossings between families and trade networks across Turkey and Iran; and more recently, a status claimed by residents of the city from the Soviet 1960s and 1970s, when these diverse urban elites were at the peak of their social capital. At the same time, however, Azerbaijan had one of the lower rates of intermarriage and out-migration of all the Soviet republics. This essay therefore asks: What does cosmopolitanism mean in this context and what does it tell us about changing Caucasus landscapes?     

The ‘president’s drug’

Netherlands Heart Journal -     

Structural and Narrative Reconstruction of Rural Residents’ Representations of ‘Nature’, ‘Wildlife’, and ‘Landscape’

The objective of this paper is the structural and narrative reconstruction of representations of ‘nature’, ‘wildlife’ and ‘landscape’, held by rural residents of the Dadia Forest Reserve. Data collection involved in-depth interviews. Employing a social representations’ approach, we recovered representational elements that are expected in the case of rural belief systems, such as negative dispositions towards wolves and foxes, as well as elements of an urban adherence, such as nature’s independence. Representational elements refer to visual aspects of the countryside, which seem compatible with the figurative nucleus of the rural idyll. Concerning ‘wildlife’, residents focused on vultures, which comprise the main tourist attraction of the reserve. Scientific knowledge adds to the complexity of the narrative schema, which corresponds to the representation of ‘wildlife’. Interviewees perceived the rural landscape as an interface between the natural and the human-conditioned environment. Our study shows that interviewees make no reference to environmental conservation or quality of life issues, as it could be expected according to relatively wide definitions of the term ‘environmentalism’. Environmental messages reinforced by ecotourism development seem to be recalled primarily in terms of their compatibility with the perceived economic benefit of local people. Despite ecotourism development, representational elements that diverge from a tourist version of ‘nature’, ‘wildlife’ and ‘landscape’ were not pronounced within rural belief-systems. Further interventions within the study area are needed, in order to address a variety of topics under the environmental conservation discourse and raise the environmental awareness of rural residents.     

Rethinking the ‘everyday’ in ‘ethnicity and everyday life’

While ‘ethnicity and everyday life’ is a familiar collocation, sociologists concerned with racism and ethnicity have not engaged very much with the extensive body of social theory that takes the ‘everyday’ as its central problematic. In this essay, I consider some of the ways in which the sociology of the everyday might be of use to those concerned with investigating ethnicity and racism. For its part, however, the sociology of the everyday has tended to be remarkably blind to the role played by racism and racialization in the modern world. It is thus no less crucial to consider how the experiences of racialized groups might help us rethink influential accounts of the everyday. To this end, I provide a discussion of pioneering texts by C. L. R. James and W. E. B. du Bois, both of whom were driven by their reflections on racism and resistance to recognize the everyday not as an unremarked context, but as, precisely, a problematic one.     

Whither ‘non-racialism’: the ‘new’ South Africa turns twenty-one

This brief essay reflects on the meaning and significance of ‘non-racialism’ in South Africa's recent past and present. I consider the version of non-racialism that shaped the transition from apartheid to a constitutional democracy as having had dual dimensions, ethical and strategic. Ethically, non-racialism has signified a principle of human recognition that exceeds the mere tolerance of difference. Strategically, non-racialism has afforded ways of managing and disciplining the historical realities of racial differences. The politicization of race in recent years has rendered the project of non-racialism more precarious: both its ethical and strategic dimensions merit further scrutiny, if the project is to be revitalized.