探讨医院图书馆数字化信息建设与服务

数字化信息时代,信息资源建设是主流的业务。本文通过对医院图书馆数字资源建设与知识服务的内容,提出医院图书馆信息资源数字化建设的基本对策和发展方向。     

医院图书馆建立学科馆员制度的制约因素探讨

目的：探讨在医院图书馆建立学科馆员制度和开展学科化服务的必要性与可行性。方法：通过上海市三级医院图书馆的人员、信息服务基础、数字化资源建设及学科馆员设置比例等的调研数据,分析其影响医院图书馆开展学科化服务的制约因素。结果：目前医院图书馆开展学科化服务存在：大环境、制度、评估指标、人员素质、和数字化资源建设六方面的主要制约因素。结论：学科馆员制度设置和学科化服务的开展是医院图书馆发展的方向和主流。通过对制约因素的揭示,在现有的条件和状态下,可通过制度保证、完善评估机制和标准、人员的继续教育和资源共建共享等措施,逐步提高医院图书馆学科馆员设置比例,以提升医院图书馆服务水平。     

上海市医院(学)图书馆现状调查的研究

目的:为了解和分析我国医院图书馆的现状,为医院图书馆进一步向规范化、合理化、现代化的发展提供客观的依据.方法:采用中国图书馆学会医院图书馆委员会统一编制的"中国医院(学)图书馆情况调查表"对上海市医院图书馆进行问卷调查.结果:对回收的数据做了总体情况、文献资源、设备、年度经费、信息资源利用、数字资源建设、资源共建块享和信息素质教育八个方面汇总分析和归纳总结.结论:图书馆工作人员中54.90%具有中高级职称,由于资源共享医院图书馆的信息资源有较大程度的拓展,但经费不能适应资源价格上涨幅度,有的图书馆硬件设备需要改进.     

CHKD在我院局域网上的应用和检索方法的探讨

21世纪人类进入了知识经济时代,知识经济是以信息化、网络化和数字化为基础,以知识化、全球化为特征、,现代信息是以电子计算机和数据库为依托,采用网络化的协作服务方式展开的[1,2]。在信息爆炸的今天,医务工作者要在自己的学科前沿进行科研,就必须查阅大量的文献,掌握学科动态,了解学科动向。因此,对信息的要求越来越迫切,我院图书馆认清形势,改变观念,整合资源,及时地引进了“中国医院知识仓库”(ChinaHospitalKnowledgeDatabase,简称CHKD),在院内局域网上应用,实现了信息资源存储数字化,传输网络化,资源共享化,为医院的临床、科研、…     

CHKD在我院局域网上的应用和检索方法的探讨

21世纪人类进入了知识经济时代,知识经济是以信息化、网络化和数字化为基础,以知识化、全球化为特征、现代信息是以电子计算机和数据库为依托,采用网络化的协作服务方式展开的。在信息爆炸的今天,医务工作要在自己的学科前沿进行科研,就必须查阅大量的献,掌握学科动态,了解学科动向。因此,对信息的要求越来越迫切,我院图书馆认清形势,改变观念,整合资源,及时地引进了“中国医院知识仓库”(China Hospital Knowledge Database,简称CHKD),在院内局域网上应用,实现了信息资源存储数字化,传输网络化,资源共享化,为医院的临床、科研、教学提供信息服务,通过一段时间的使用,收到了很好的效果。     

网络环境下中小型医院图书馆的现状和发展

进入21世纪以来,以网络为中心的计算机技术、通信技术、信息数字化技术以及多媒体技术的迅猛发展,给传统的图书馆带来极大的冲击,图书馆正经历着巨大的变化,对于大型图书馆来说,人员充足,资金雄厚,能顺应潮流,发展很快,很有生机,但对于一些中小型馆来说,如何在网络环境下适应社会的发展,搞好自己的资源建设和信息的服务工作,是我们亟待解决的问题。     

论网络环境下图书馆多元化服务与创新

互联网的迅速普及,数字化图书馆也已经逐渐普及,网络也拓宽了图书馆的信息服务渠道,各图书馆之间实现了资源共享的同时也为广大读者提供了更广泛的信息资源。因此带来了图书馆服务工作的变化和创新,以信息和知识检索、收集、传播发布为主的多功能服务发生转变,图书馆走向了多元化服务阶段。     

图书数字化建设与计算机网络技术管理

随着信息化技术的逐步普及,图书馆建设也面临着建设数字化图书馆的重要任务,如何高效、切合实际的建设数字化图书馆是图书馆人面临的重要课题。本文在分析数字化建设定义基础上,分析了如何进行定位及建设路径问题,以及计算机网络技术在图书馆的合理应用等问题,希望对数字化图书馆建设起到一定的参考和帮助作用。     

基于信息化的病人费用结算模式探讨

基于医院现行信息化框架,提出病人费用结算流程一揽子信息化解决方案,并选取样本医院进行方案后续实施与考察,力图突破传统方法的局限,,实现简化结算流程、消除信息壁垒、保障病患资金安全、提高运行效率的目的,为提升医疗资源利用率、建设符合中国医疗卫生体制要求的数字化医院提供参考。     

河北省三级甲等综合医院图书馆网站建设现状与分析

目的 了解河北省三级甲等综合医院图书馆网站建设的现状。方法 选取河北省22家三级甲等医院网站,采用百度引擎对医院网站进行搜索,对出现的图书馆网站及相关信息进行记录、归类和整理。结果 被调查的22家医院图书馆网站中,7家（33.33%）医院网站无图书馆网站及其相关信息;6家（28.57%）在医院网站主界面设置图书馆链接;8家（38.10%）医院在主网页中科教栏及其他栏目中涵盖图书馆链接,且多数医院图书馆网站信息更新频率慢。结论 河北省三级甲等综合医院图书馆网站建设较为落后,应采取相应措施,促进医院图书馆网站逐步完善。     

A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus (2019-nCoV) Potentially Related to Viral Transmissibility

正Dear Editor,In December 2019, a novel human coronavirus caused an epidemic of severe pneumonia(Coronavirus Disease 2019,COVID-19) in Wuhan, Hubei, China(Wu et al. 2020; Zhu et al. 2020). So far, this virus has spread to all areas of China and even to other countries. The epidemic has caused 67,102 confirmed infections with 1526 fatal cases     

Curcuminoids as inhibitors of thioredoxin reductase: A receptor based pharmacophore study with distance mapping of the active site

Curcumin is the yellow pigment of turmeric that interacts irreversibly forming an adduct with thioredoxin reductase (TrxR), an enzyme responsible for redox control of cell and defence against oxidative stress. Docking at both the active sites of TrxR was performed to compare the potency of three naturally occurring curcuminoids, namely curcumin, demethoxy curcumin and bis-demethoxy curcumin. Results show that active sites of TrxR occur at the junction of E and F chains. Volume and area of both cavities is predicted. It has been concluded by distance mapping of the most active conformations that Se atom of catalytic residue SeCYS498, is at a distance of 3.56 from C13 of demethoxy curcumin at the E chain active site, whereas C13 carbon atom forms adduct with Se atom of SeCys 498. We report that at least one methoxy group in curcuminoids is necessary for interation with catalytic residues of thioredoxin. Pharmacophore of both active sites of the TrxR receptor for curcumin and demethoxy curcumin molecules has been drawn and proposed for design and synthesis of most probable potent antiproliferative synthetic drugs.     

Comparative morphology of the carpel in the Liliaceae: Hewardieae, Petrosavieae, and Tricyrteae

The young pistils in the melanthioid tribes, Hewardieae, Petrosavieae and Tricyrteae, are uniformly tricarpellate and syncarpous. They lack raphide idioblasts. All are multiovulate, with bitegmic ovules. The Petrosavieae are marked by the presence of septal glands and incomplete syncarpy. Tepals and stamens adhere to the ovary in the Hewardieae and the Petrosavieae but not in the Tricyrteae. Two vascular bundles occur in the stamens of the Hewartlieae and Tricyrtis latifolia. Ventral bundles in the upper part of the ovary of the Hewardieae are continuous with compound septal bundles and placental bundles in the lower part. Putative ventral bundles occur in the alternate position in the Tricyrteae and putative placental bundles in the opposite. position in the Petrosavieae. The dichtomously branched stigma in each carpel of the Tricyrteae is supplied by a bifurcated dorsal bundle.     

Enterovirus 71 3C proteolytically processes the histone H3 N-terminal tail during infection

Highlights
1. The N-terminal tail of histone H3 is specifically cleaved during EV71 infection.
2. Viral protease 3C is identified as a protease responsible for proteolytically processing the N-terminal H3 tail.
3. Our finding reveals a new epigenetic regulatory mechanism for Enterovirus 71 in virus-host interactions.     

Detection of EBV and HHV6 in the Brain Tissue of Patients with Rasmussen’s Encephalitis

Rasmussen’s encephalitis (RE) is a rare pediatric neurological disorder, and the exact etiology is not clear. Viral infection may be involved in the pathogenesis of RE, but conflicting results have reported. In this study, we evaluated the expression of both Epstein-Barr virus (EBV) and human herpes virus (HHV) 6 antigens in brain sections from 30 patients with RE and 16 control individuals by immunohistochemistry. In the RE group, EBV and HHV6 antigens were detected in 56.7% (17/30) and 50% (15/30) of individuals, respectively. In contrast, no detectable EBV and HHV6 antigen expression was found in brain tissues of the control group. The co-expression of EBV and HHV6 was detected in 20.0% (6/30) of individuals. In particular, a 4-year-old boy had a typical clinical course, including a medical history of viral encephalitis, intractable epilepsy, and hemispheric atrophy. The co-expression of EBV and HHV6 was detected in neurons and astrocytes in the brain tissue, accompanied by a high frequency of CD8⁺ T cells. Our results suggest that EBV and HHV6 infection and the activation of CD8⁺ T cells are involved in the pathogenesis of RE.     

Perinatal Vertical Transmission of Chikungunya Virus in Ruili,a Town on the Border between China and Myanmar

正Dear Editor,Chikungunya virus (CHIKV), an arbovirus in the family of Togaviridae, genus Alphavirus, is transmitted by the A.aegyptii or A. albopictus mosquito, and causes disease in humans characterized by fever, rash, and arthralgia (Silva and Dermody 2017; Suhrbier 2019). It was first reported in 1953 in Tanzania, and caused only a few outbreaks and sporadic cases in Africa and Asia in last century. However, in the epidemic in 2004, CHIKV acquired mutations that conferred enhanced transmission by the A. albopictus mosquito(Schuffenecker et al. 2006). Since then, it has successively caused outbreaks in Africa, the Indian Ocean, South East Asia, the South America, and Europe (Zeller et al. 2016).     

Development of a Novel Reverse Transcription Loop-Mediated Isothermal Amplification Method for Rapid Detection of SARS-CoV-2

In conclusion, the novel visual RT-LAMP assay is a simple, rapid, and sensitive approach for detection of SARS-CoV-2, and it is ready for application in primary care and community hospitals or health care centers, and even patients' own houses in response to the current SARS-CoV-2 epidemic because the assay does not require sophisticated equipment and skilled personnel. Furthermore, it is also ready to be used in fields for screening samples from wild animals and environments to facilitate the identification of potential intermediate hosts that mediate the cross-species transmission of SARS-CoV-2 from bats to humans.