共查询到20条相似文献,搜索用时 125 毫秒
1.
Takehiko Oka Yuhei Nishimura Minoru Hirano Yasuhito Shimada Noriko Umemoto Junya Kuroyanagi Norihiro Nishimura Toshio Tanaka 《BMC physiology》2010,10(1):21
Background
Obesity is a multifactorial disorder influenced by genetic and environmental factors. Animal models of obesity are required to help us understand the signaling pathways underlying this condition. Zebrafish possess many structural and functional similarities with humans and have been used to model various human diseases, including a genetic model of obesity. The purpose of this study was to establish a zebrafish model of diet-induced obesity (DIO). 相似文献2.
Mark P Hehir Audrey T Moynihan Siobhan V Glavey John J Morrison 《Reproductive biology and endocrinology : RB&E》2009,7(1):6-7
Background
The increasing prevalence of obesity constitutes a major health problem in obstetrics with implications for feto-maternal growth and wellbeing. This study investigated and compared the contractile properties of umbilical arteries excised from obese women, with those excised from women with a normal body mass index (BMI). 相似文献3.
Background
Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder associated with ovulatory dysfunction, abdominal obesity, hyperandrogenism, hypertension, and insulin resistance. 相似文献4.
Qing Lin Ling Song Poon Junling Chen Linan Cheng Basil HoYuen Peter CK Leung 《Reproductive biology and endocrinology : RB&E》2009,7(1):115-8
Background
Obesity has been linked to an increased risk of female infertility. Leptin, an adipocytokine which is elevated during obesity, may influence gonadal function through modulating steroidogenesis in granulosa cells. 相似文献5.
Marco Candela Clarissa Consolandi Marco Severgnini Elena Biagi Bianca Castiglioni Beatrice Vitali Gianluca De Bellis Patrizia Brigidi 《BMC microbiology》2010,10(1):116
Background
Affecting the core functional microbiome, peculiar high level taxonomic unbalances of the human intestinal microbiota have been recently associated with specific diseases, such as obesity, inflammatory bowel diseases, and intestinal inflammation. 相似文献6.
Background
Elevated glucocorticoid production and reduced hypothalamic POMC mRNA can cause obese phenotypes. Conversely, adrenalectomy can reverse obese phenotypes caused by the absence of leptin, a model in which glucocorticoid production is elevated. Adrenalectomy also increases hypothalamic POMC mRNA in leptin-deficient mice. However most forms of human obesity do not appear to entail elevated plasma glucocorticoids. It is therefore not clear if reducing glucocorticoid production would be useful to treat these forms of obesity. We hypothesized that adrenalectomy would increase hypothalamic POMC mRNA and reverse obese phenotypes in obesity due to a high-fat diet as it does in obesity due to leptin deficiency. 相似文献7.
Timothy M Griffin Beverley Fermor Janet L Huebner Virginia B Kraus Ramona M Rodriguiz William C Wetsel Li Cao Lori A Setton Farshid Guilak 《Arthritis research & therapy》2010,12(4):R130-18
Introduction
Obesity is a major risk factor for the development of osteoarthritis in both weight-bearing and nonweight-bearing joints. The mechanisms by which obesity influences the structural or symptomatic features of osteoarthritis are not well understood, but may include systemic inflammation associated with increased adiposity. In this study, we examined biomechanical, neurobehavioral, inflammatory, and osteoarthritic changes in C57BL/6J mice fed a high-fat diet. 相似文献8.
Muna J. Tahir Karin B. Michels Walter C. Willett Michele R. Forman 《Obesity (Silver Spring, Md.)》2018,26(10):1611-1618
Objective
This study aimed to examine the association between age at solid food (SF) introduction and obesity throughout the life course.Methods
Among 31,816 mother– nurse daughter dyads in the Nurses' Mothers' Cohort Study and the Nurses' Health Study II, information was collected on age at SF introduction, body somatotype at ages 5 and 10, and Body Mass Index at age 18 and in adulthood. Odds ratios (ORs) and 95% confidence intervals (95% CIs) for obesity throughout life were estimated using logistic regression models with adjustment for parental and nurse daughter covariates.Results
Nurse daughters introduced to SF at ≥ 9 months versus 6 to 9 months had marginally higher age‐adjusted (OR: 1.21; 95% CI: 1.01, 1.47) and covariate‐adjusted (OR: 1.22; 95% CI: 1.01, 1.47) odds of obesity at age 5. Age at SF introduction was not related to obesity at ages 10 and 18 or in adulthood.Conclusions
Late age at SF introduction was marginally associated with obesity at age 5, but this association did not persist throughout the life course. 相似文献9.
Background
Obesity causes or exacerbates a host of medical conditions, including cardiovascular, pulmonary, and endocrine diseases. Recently obesity in elderly women was associated with greater risk of dementia, white matter ischemic changes, and greater brain atrophy. The purpose of this study was to determine whether body type affects global brain volume, a marker of atrophy, in middle-aged men and women. 相似文献10.
Xue Zhang Li Fu Qiufang Zhang Liying Yan Yanmin Ma Binbin Tu Nana Liu Jie Qiao 《Reproductive biology and endocrinology : RB&E》2011,9(1):46
Background
Tribbles 3 (TRB3) affects insulin signalling by inhibiting insulin-stimulated Akt phosphorylation and subsequent activation. A single nucleotide polymorphism located in the second extron of the human TRB3 gene is thought to be associated with insulin resistance. The latter is a core abnormality in PCOS independent of obesity. The present study was designed to clarify the relationships of TRB3 Q84R polymorphism with PCOS in a Chinese women group. 相似文献11.
Kiesewetter S Köpsel A Mai K Stroux A Bobbert T Spranger J Köpp W Deter HC Kallenbach-Dermutz B 《BioPsychoSocial medicine》2012,6(1):3
Background & Aims
The long-term success of life-style interventions in the treatment of obesity is limited. Although psychological factors have been suggested to modify therapeutic effects, specifically the implications of attachment styles and the patient-therapist relationship have not been examined in detail yet. 相似文献12.
Elizabeth Watson Samira Fargali Haruka Okamoto Masato Sadahiro Ronald E Gordon Tandra Chakraborty Mark W Sleeman Stephen R Salton 《BMC physiology》2009,9(1):19-20
Background
Previous studies of mixed background mice have demonstrated that targeted deletion of Vgf produces a lean, hypermetabolic mouse that is resistant to diet-, lesion-, and genetically-induced obesity. To investigate potential mechanism(s) and site(s) of action of VGF, a neuronal and endocrine secreted protein and neuropeptide precursor, we further analyzed the metabolic phenotypes of two independent VGF knockout lines on C57Bl6 backgrounds. 相似文献13.
Sharon L Brennan Flavia M Cicuttini Julie A Pasco Margaret J Henry Yuanyuan Wang Mark A Kotowicz Geoff C Nicholson Anita E Wluka 《Arthritis research & therapy》2010,12(4):R139-7
Introduction
Although obesity is a modifiable risk factor for knee osteoarthritis (OA), the effect of weight gain on knee structure in young and healthy adults has not been examined. The aim of this study was to examine the relationship between body mass index (BMI), and change in BMI over the preceding 10-year period, and knee structure (cartilage defects, cartilage volume and bone marrow lesions (BMLs)) in a population-based sample of young to middle-aged females. 相似文献14.
Rok Kosir Jure Acimovic Marko Golicnik Martina Perse Gregor Majdic Martina Fink Damjana Rozman 《BMC molecular biology》2010,11(1):60
Background
Circadian rhythms have a profound effect on human health. Their disruption can lead to serious pathologies, such as cancer and obesity. Gene expression studies in these pathologies are often studied in different mouse strains by quantitative real time polymerase chain reaction (qPCR). Selection of reference genes is a crucial step of qPCR experiments. Recent studies show that reference gene stability can vary between species and tissues, but none has taken circadian experiments into consideration. 相似文献15.
Introduction
Increasing obesity and type 2 diabetes, in part due to the high-fat (HF) Western diet, parallels an increased incidence of osteoarthritis (OA). This study was undertaken to establish a causal relation between the HF diet and accelerated OA progression in a mouse model and to determine the relative roles of weight gain and metabolic dysregulation in this progression. 相似文献16.
Vitantonio Di Bello Iacopo Fabiani Lorenzo Conte Valentina Barletta Maria Grazia Delle Donne Cucco Cuono Laura Anna Leo Frank Lloyd Dini Mario Marzilli Aldo Pinchera Ferruccio Santini 《Obesity (Silver Spring, Md.)》2013,21(5):881-892
Objective:
Obesity has reached global epidemic proportions and is associated with numerous comorbidities, including major cardiovascular (CV) diseases.Design and Methods:
It has many adverse effects on hemodynamics and CV structure and function: it increases total blood volume and cardiac output, and the cardiac workload is greater. Typically, obese patients have a higher cardiac output but a lower level of total peripheral resistance at any given level of arterial pressure. Most of the increase in cardiac output in obesity is caused by stroke volume, although heart rate typically mildly increases also due to enhanced sympathetic activation.Results:
Over the last few years, experimental investigations have unraveled some important pathogenetic mechanisms that may underlie a specific form of “obesity cardiomyopathy.” Bariatric surgery represents an effective alternative to treat obesity when nonsurgical weight loss programs (diet + behavior modifications + regular exercise) have failed. A great numbers of questions are still open in the global comprehension of the pathophysiological interactions between obesity and heart.Conclusion:
Conventional two‐dimensional Doppler echocardiography, integrated by relative new technological ultrasonic approaches, represents the reference technique to study and possibly clarify both the very complex hemodynamic changes induced by obesity and those relative to obesity treatment. 相似文献17.
Background
Obesity is a global public health problem and a risk factor for several diseases that financially impact healthcare systems.Objective
To estimate the direct costs attributable to obesity (body mass index {BMI} ≥ 30 kg/m2) and morbid obesity (BMI ≥ 40 kg/m2) in adults aged ≥ 20 incurred by the Brazilian public health system in 2011.Settings
Public hospitals and outpatient care.Methods
A cost-of-illness method was adopted using a top-down approach based on prevalence. The proportion of the cost of each obesity-associated comorbidity was calculated and obesity prevalence was used to calculate attributable risk. Direct healthcare cost data (inpatient care, bariatric surgery, outpatient care, medications and diagnostic procedures) were extracted from the Ministry of Health information systems, available on the web.Results
Direct costs attributable to obesity totaled US$ 269.6 million (1.86% of all expenditures on medium- and high-complexity health care). The cost of morbid obesity accounted for 23.8% (US$ 64.2 million) of all obesity-related costs despite being 18 times less prevalent than obesity. Bariatric surgery costs in Brazil totaled US$ 17.4 million in 2011. The cost of morbid obesity in women was five times higher than it was in men.Conclusion
The cost of morbid obesity was found to be proportionally higher than the cost of obesity. If the current epidemic were not reversed, the prevalence of obesity in Brazil will increase gradually in the coming years, as well as its costs, having serious implications for the financial sustainability of the Brazilian public health system. 相似文献18.
Zhiqin Bu Kakei Kuok Jie Meng Rui Wang Bei Xu Hanwang Zhang 《Reproductive biology and endocrinology : RB&E》2012,10(1):10
Background
Polycystic ovary syndrome (PCOS) is linked to obesity, impaired glucose tolerance and diabetes. Recently, studies have found that preptin enhances insulin secretion in rats and might play a role in the pathogenesis of diabetes and PCOS in humans. The aim of this study was to evaluate the relationship between PCOS, glucose tolerance status, and serum preptin level. 相似文献19.
Treatment of pregnant rats with oleoyl-estrone slows down pup fat deposition after weaning 总被引:1,自引:0,他引:1
Beatriz García-Peláez Ruth Vilà Xavier Remesar 《Reproductive biology and endocrinology : RB&E》2008,6(1):23
Background
In rats, oral oleoyl-estrone (OE) decreases food intake and body lipid content. The aim of this study was to determine whether OE treatment affects the energy metabolism of pregnant rats and eventually, of their pups; i.e. changes in normal growth patterns and the onset of obesity after weaning. 相似文献20.
Ke Wang Dingming Wang Li Pan Yangwen Yu Fen Dong Ling Li Li Wang Tao Liu Xianjia Zeng Liangxian Sun Guangjin Zhu Kui Feng Junmei Miao Jonasson Zhenglai Wu Ke Xu Xinglong Pang Ting Chen Hui Pan Jin Ma Yong Zhong Bo Ping Guangliang Shan 《PloS one》2015,10(6)