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Adrenalectomy stimulates hypothalamic proopiomelanocortin expression but does not correct diet-induced obesity |
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| Authors: | Hideo?Makimura Tooru?M?Mizuno Joe?Beasley Jeffrey?H?Silverstein |
| Institution: | (1) Fishberg Center for Neurobiology, Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York USA 10029, USA;(2) Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York 10029, USA;(3) Department of Anesthesiology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York 10029, USA |
| Abstract: | BackgroundElevated glucocorticoid production and reduced hypothalamic POMC mRNA can cause obese phenotypes. Conversely, adrenalectomy can reverse obese phenotypes caused by the absence of leptin, a model in which glucocorticoid production is elevated. Adrenalectomy also increases hypothalamic POMC mRNA in leptin-deficient mice. However most forms of human obesity do not appear to entail elevated plasma glucocorticoids. It is therefore not clear if reducing glucocorticoid production would be useful to treat these forms of obesity. We hypothesized that adrenalectomy would increase hypothalamic POMC mRNA and reverse obese phenotypes in obesity due to a high-fat diet as it does in obesity due to leptin deficiency. |
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