共查询到20条相似文献,搜索用时 859 毫秒
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Background
The alterations of the glutathione peroxidase enzyme complex system occur in physiological conditions such as aging and oxidative stress consequent to strenuous exercise. 相似文献2.
Biniecka M Kennedy A Ng CT Chang TC Balogh E Fox E Veale DJ Fearon U O'Sullivan JN 《Arthritis research & therapy》2011,13(4):R121
Introduction
To examine the effects of tumour necrosis factor (TNF) blocking therapy on the levels of early mitochondrial genome alterations and oxidative stress. 相似文献3.
Ma?gorzata Przyby?o Dorota Hoja-Lukowicz Anna Lityńska Piotr Laidler 《Cancer cell international》2002,2(1):6
Background
The aim of the present study was to determine whether stage of invasiveness of bladder cancer cell lines contributes to alterations in glycan pattern of their cadherins. 相似文献4.
Angel R Barchuk Alexandre S Cristino Robert Kucharski Luciano F Costa Zilá LP Simões Ryszard Maleszka 《BMC developmental biology》2007,7(1):70
Background
In honeybees, differential feeding of female larvae promotes the occurrence of two different phenotypes, a queen and a worker, from identical genotypes, through incremental alterations, which affect general growth, and character state alterations that result in the presence or absence of specific structures. Although previous studies revealed a link between incremental alterations and differential expression of physiometabolic genes, the molecular changes accompanying character state alterations remain unknown. 相似文献5.
Kim JS Kroin JS Li X An HS Buvanendran A Yan D Tuman KJ van Wijnen AJ Chen D Im HJ 《Arthritis research & therapy》2011,13(5):R165
Introduction
Degeneration of the interverterbral disk is as a cause of low-back pain is increasing. To gain insight into relationships between biological processes, structural alterations and behavioral pain, we created an animal model in rats. 相似文献6.
Beatriz Rodríguez-Bayona Ana Ramos-Amaya José J Pérez-Venegas Carmen Rodríguez José A Brieva 《Arthritis research & therapy》2010,12(3):R108
Introduction
Systemic lupus erythematosus (SLE) is characterized by B cell hyper-activation and auto-reactivity resulting in pathogenic auto-antibody generation. The phenotypic analysis of blood B cell subsets can be used to understand these alterations. 相似文献7.
Kristel Brys Natascha Castelein Filip Matthijssens Jacques R Vanfleteren Bart P Braeckman 《BMC biology》2010,8(1):91
Background
The gene daf-2 encodes the single insulin/insulin growth factor-1-like receptor of Caenorhabditis elegans. The reduction-of-function allele e1370 induces several metabolic alterations and doubles lifespan. 相似文献8.
Tim J Dexter David Sims Costas Mitsopoulos Alan Mackay Anita Grigoriadis Amar S Ahmad Marketa Zvelebil 《BMC systems biology》2010,4(1):127
Background
Genomic copy number changes and regional alterations in epigenetic states have been linked to grade in breast cancer. However, the relative contribution of specific alterations to the pathology of different breast cancer subtypes remains unclear. The heterogeneity and interplay of genomic and epigenetic variations means that large datasets and statistical data mining methods are required to uncover recurrent patterns that are likely to be important in cancer progression. 相似文献9.
Background
Molecular recognition between enzymes and proteic inhibitors is crucial for normal functioning of many biological pathways. Mutations in either the enzyme or the inhibitor protein often lead to a modulation of the binding affinity with no major alterations in the 3D structure of the complex. 相似文献10.
Breno H Caneguim Paulo S Cerri Luís C Spolidório Sandra M Miraglia Estela Sasso-Cerri 《Reproductive biology and endocrinology : RB&E》2009,7(1):19
Background
Tacrolimus (FK-506) is an immunosuppressant that binds to a specific immunophilin, resulting in the suppression of the cellular immune response during transplant rejection. Except for some alterations in the spermatozoa, testicular morphological alterations have not been described in rats treated with tacrolimus. In the present study, we purpose to evaluate if the treatment with tacrolimus at long term of follow-up interferes in the integrity of the seminiferous tubules. 相似文献11.
Volkan Yıldırım Servet Özcan Dörte Becher Knut Büttner Michael Hecker Gülay Özcengiz 《Proteome science》2011,9(1):12
Background
Total soluble proteome alterations of white rot fungus Phanerochaete chrysosporium in response to different doses (25, 50 and 100 μM) of Pb (II) were characterized by 2DE in combination with MALDI-TOF-MS. 相似文献12.
Background
Gene synthesis technologies are an important tool for structural biology projects, allowing increased protein expression through codon optimization and facilitating sequence alterations. Existing methods, however, can be complex and not always reproducible, prompting researchers to use commercial suppliers rather than synthesize genes themselves. 相似文献13.
Elmar H Pinkhardt Ludger Tebartz van Elst Albert C Ludolph Jan Kassubek 《BMC neurology》2006,6(1):48-6
Background
Evidence for extra-motor involvement in non-demented patients with amyotrophic lateral sclerosis (ALS) has been provided by multiple studies, in particular neuropathological studies have demonstrated neuronal loss in the amygdala. The aim of this study was to investigate possible alterations of amygdala volumes in vivo. 相似文献14.
Jutta?Bradtke Harald?Balz Christa?Fonatsch Barbara?Heinze Anna?Jauch Brigitte?Mohr Claudia?Schoch Harald?Rieder
Background
The analysis of complex cytogenetic databases of distinct leukaemia entities may help to detect rare recurring chromosome aberrations, minimal common regions of gains and losses, and also hot spots of genomic rearrangements. The patterns of the karyotype alterations may provide insights into the genetic pathways of disease progression. 相似文献15.
Matthias Majer James F Jones Elizabeth R Unger Laura Solomon Youngblood Michael J Decker Brian Gurbaxani Christine Heim William C Reeves 《BMC neurology》2007,7(1):40
Background
Complaints of unrefreshing sleep are a prominent component of chronic fatigue syndrome (CFS); yet, polysomnographic studies have not consistently documented sleep abnormalities in CFS patients. We conducted this study to determine whether alterations in objective sleep characteristics are associated with subjective measures of poor sleep quality in persons with CFS. 相似文献16.
Hua Dong Li Luo Shengjun Hong Hoicheong Siu Yanghua Xiao Li Jin Rui Chen Momiao Xiong 《BMC systems biology》2010,4(1):163
Background
Glioblastoma arises from complex interactions between a variety of genetic alterations and environmental perturbations. Little attention has been paid to understanding how genetic variations, altered gene expression and microRNA (miRNA) expression are integrated into networks which act together to alter regulation and finally lead to the emergence of complex phenotypes and glioblastoma. 相似文献17.
Zdenka Drastichova Jitka Skrabalova Jan Neckar Frantisek Kolar Jiri Novotny 《Journal of biomedical science》2011,18(1):89
Background
Morphine is used in clinical practice as a highly effective painkiller as well as the drug of choice for treatment of certain heart diseases. However, there is lack of information about its effect on protein expression in the heart. Therefore, here we aimed to identify the presumed alterations in rat myocardial protein levels after prolonged morphine treatment. 相似文献18.
Background
The ubiquitin-proteasome system is the predominant pathway for myofibrillar proteolysis but a previous study in C2C12 myotubes only observed alterations in lysosome-dependent proteolysis in response to complete starvation of amino acids or leucine from the media. Here, we determined the interaction between insulin and amino acids in the regulation of myotube proteolysis 相似文献19.
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