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Amino acids and insulin act additively to regulate components of the ubiquitin-proteasome pathway in C2C12 myotubes |
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| Authors: | Fouzia Sadiq David G Hazlerigg Michael A Lomax |
| Institution: | (1) Division of Cell & Molecular Biology, Imperial College London, Wye Campus, Wye, Ashford, Kent, TN25 5AH, UK;(2) School of Biological Sciences, University of Aberdeen, Aberdeen, AB24 5UA, UK;(3) Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen, AB25 2ZD, UK |
| Abstract: | BackgroundThe ubiquitin-proteasome system is the predominant pathway for myofibrillar proteolysis but a previous study in C2C12 myotubes only observed alterations in lysosome-dependent proteolysis in response to complete starvation of amino acids or leucine from the media. Here, we determined the interaction between insulin and amino acids in the regulation of myotube proteolysis |
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