乌鲁木齐河源区高寒冰缘植物化学元素的含量特征

分析了乌鲁木齐河源区３５种冰缘植物１６个元素含量的特征,含量〉５０００μｇ／ｇ的元素为Ｃａ,在１０００￣５０００μｇ／ｇ之间的元素有Ｋ、Ｍｇ、Ｎａ、Ｆｅ,在１０￣２００μｇ／ｇ之间的元素有Ｚｎ、Ｍｎ、Ｓｒ、Ｃｒ、Ｐｂ,含量〈１０μｇ／ｇ的元素有Ｃｕ、Ａｇ、Ｃｏ、Ｌｉ、Ｃｄ、Ｎｉ。元素含量特点是Ｃａ〉Ｋ型。大多数冰缘植物的Ｆｅ、Ｓｒ、Ｍｎ、Ｃｒ、Ｃｄ的含量高于一般的自然含量,但Ｃｕ的含量低于陆生植物     

长江三峡地区优势植物的化学元素含量特征

分析了三峡地区１６种优势植物２０个元素的自然含量特征。〉１０００μｇ．ｇ＾－１的元素有Ｃａ,Ｋ和Ｍｇ,１００－１０００μｇ．ｇ＾－１的元素有Ａｌ,Ｐ,Ｓｉ,Ｆｅ,Ｓ和Ｍｎ,１０－１００μｇ．ｇ．＾－１的元素有Ｎａ,Ｓｒ,Ｚｎ,Ｂ,〈１０μｇ．ｇ＾－１的元素有Ｔｉ,Ｃｕ,Ｎｉ,Ｃｒ,Ｍｏ,Ｃｄ和Ｖ。     

川金丝猴体毛微量元素的分析

应用等离子发射光谱法分析了秦岭产川金丝猴体毛中Ｎａ、Ｋ、Ｃａ、Ｍｇ、Ｚｎ、Ｃｄ、Ｃｏ、Ｃｕ、Ｎｉ、Ｓｒ、Ｌｉ、Ｆｅ、Ａｌ、Ｍｎ、Ｂ、Ｐ１６种微量元素的含量,发现除Ｚｎ与Ｍｎ有显著的性别差异外,余者无显著的性别差异,一般雄性稍高于雌性。与四川产川金丝猴体毛中的Ｚｎ、Ｃａ、Ｃｕ、Ｆｅ含量比较,两地区样本均有极显著的差异。     

火焰原子吸收光谱法对葡萄汁,葡萄酒中的微量元素分析

采用火焰原子吸收光谱法对中国长城葡萄公司所采用的葡萄汁和生产的葡萄酒中的微量元素进行分析,结果表明Ｋ＾＋,ｍｇ＾＋＋较高,其次是Ｃａ＾＋＋ｆ,Ｎａ＾＋,而Ｆｅ＾＋＋Ｃｕ＾＋＋,Ｚｎ＾＋＋含量较少,同时,经过降酸处理后,Ｋ＾＋,Ｎａ＾＋等一价金属离子含量不降低而Ｃａ＾＋＋,Ｍｇ＾＋＋,Ｃｕ＾＋＋,Ｚｎ＾＋＋等二价离子降低。     

草药肾叶橐吾中的微量元素分析

用原子吸收光谱法和发射光谱法以及荧光分光光度法测定了肾叶橐吾中的Ｚｎ、Ｆｅ、Ｃｕ、Ｓｒ、Ｎｉ、Ｍｎ、Ｃｒ、Ｍｏ、Ｓｅ、Ｃｄ、Ｃｏ、Ｐｂ、Ｂａ、Ｂ、Ｐ等含量,同时比较了野生品与园栽品中的含量,为开发应用提供了实验依据。     

翅果油树体内矿质元素的初步研究

本文采用等离子光谱法和原子吸收火焰法测定翅果油树Ｅｌａｅａｇｎｕｓｍｏｌｌｉｓ体内的１５种矿质元素,即Ｃａ、Ｍｇ、Ｐ、Ｋ．Ｎａ、Ｆｅ、Ｃｕ、Ｚｎ、Ｍｎ、Ｃｒ、Ｎｉ、Ｍｏ、Ａｌ．Ｓｒ和Ｂａ。结果表明,在不同器官及同一器官不同部位或不同生长阶段,其矿质元素含量均有显著差异。总体上看,该种植物矿质元素含量丰富,尤其以根皮、幼叶和种仁中更为突出。     

缙云山常绿阔叶林四川大头茶果实中矿质营养元素含量及季节动态

本文测定了缙云山常绿阔叶林中四川大头茶果实中Ｎ,Ｐ,Ｋ,Ｃａ,Ｍｇ,Ｃｕ,Ｚｎ,Ｆｅ,Ｍｎ９种矿质营养元素的含量,研究了这些元素的季节吸收特点与繁殖分配,并探讨了这些元素与某些土壤化学因素之间的关系,结果表明：四川大头茶果实在生长期内矿质营养元素含量随季节而变化,各元素平均含量顺序为：Ｎ＞Ｋ＞Ｃａ＞Ｍｇ＞Ｐ＞Ｍｎ＞Ｆｅ＞Ｚｎ＞Ｃｕ。土壤中化学因子与四川大头茶果实中常量元素含量之间的关系密切,果实中Ｎ含量受土壤中Ｎ,Ｐ,Ｋ含量的综合影响,土壤有机质最终会影响到果实中Ｎ,Ｐ,Ｋ,Ｃａ的吸收,矿质元素的果实繁殖分配量与果实净生物生产量分配之间不存在特定的比例关系。果实元素分配所占比例的大小顺序为Ｐ＞Ｎ＞Ｋ＞Ｃａ＞Ｆｅ＞Ｍｇ＞Ｍｎ＞Ｚｎ＞Ｃｕ。     

高原鼢鼠和高原鼠兔骨骼无机化学成分的研究Ⅱ.必需微量元素

本文报道了高原鼢鼠和高原鼠兔整体骨骼及头骨、脊柱骨和下肢骨中Ｃｕ、Ｚｎ、Ｆｅ、Ｍｎ、Ｃｏ、Ｎｉ、Ｍｏ、Ｃｒ、Ｔｉ、Ｆ、Ｓｅ和Ｇｅ１２种必需微量元素的含量,并进行了显著性差异和相关性分析。结果表明：只有Ｃｕ的含量在两种动物骨骼中没有显著性差异（Ｐ＞０．０５）,其余１１种元素均有显著性或极显著性差异（Ｐ＜０．０５或Ｐ＜０．０１）,其中Ｚｎ、Ｆｅ、Ｍｎ、Ｃｏ、Ｎｉ、Ｍｏ、Ｆ和Ｓｅ的含量,高原鼢鼠＞高原鼠兔,而Ｃｒ、Ｔｉ和Ｇｅ的含量,高原鼠兔＞高原鼢鼠。微量元素在头骨、脊柱骨和下肢骨中分布很不均衡,以头骨的微量元素最为丰富     

草药肾叶橐吾中和微量元素分析

用原子吸收光谱法以及荧光分光光度法测定了肾叶橐吾中的Ｚｎ、Ｆｅ、Ｃｕ、Ｓｒ、Ｎｉ、Ｍｎ、Ｃｒ、Ｓｅ、Ｃｄ、Ｃｏ、Ｐｂ、Ｂａ、Ｂ、Ｐ等含量,同时比较了野生品与园栽品中的含量,为开发应用提供了实验依据。     

西北地区骆驼蓬属元素化学成分的分析

应用原子吸收光谱法对西北地区骆驼蓬属植物叶和种子中８种化学元素的含量进行了测定。结果表明：Ｋ、Ｎａ、Ｃａ、Ｍｇ的含量变化为同一分布区的不同种间大于不同分布区的同种间,Ｆｅ、Ｍｎ、Ｚｎ的含量变化为不同分布区的同种间大于同一分布区的不同种间,Ｃｕ的含量变化在不同种属、不同环境、不同器官中相对较小。叶中Ｆｅ、Ｍｎ、Ｋ、Ｍｇ的含量高于种子,种子中Ｚｎ的含量高于叶。Ｋ、Ｎａ含量与抗旱性有关,不同旱生植物中的化学元素含量呈多样性变化。     

Cd2+、Hg2+对菱幼苗生长及其超氧化物歧化酶、过氧化物酶活性的影响

利用不同浓度Ｃｄ＾２＋、Ｈｇ＾２＋处理菱幼苗,研究重金属离子对菱生长、超氧化物歧化酶（ＳＯＤ）、过氧化物酶（ＰＯＤ）活性的影响,比较了Ｃｄ＾２＋、Ｈｇ＾２＋对同一植物的毒性差异,Ｃｄ＾２＋、Ｈｇ＾＾２＋各处理浓度与均抑制菱幼苗生长,使叶绿素含量下降,Ｃｄ＾２＋的抑制作用比Ｈｇ＾２＋的作用明显。Ｃｄ＾２＋、Ｈｇ＾２＋对ＳＯＤ、ＰＯＤ活性有不同的影响效果;Ｃｄ＾２＋处理最艉地ＳＯＤ、ＰＯＤ活性升高,但     

SYNTHESIS AND BIOLOGICAL ACTIVITY OF CYCLIC ADP-CARBOCYCLIC-RIBOSE ANALOGS: STRUCTURE-ACTIVITY RELATIONSHIP AND CONFORMATIONAL ANALYSIS OF N-1-CARBOCYCLIC-RIBOSE MOIETY

Several cyclic ADP-carbocyclic-ribose analogs 3–10 modified in the N-1-carbocyclic-ribose moiety were synthesized. Their Ca²⁺-releasing activity was estimated in sea urchin eggs to show that the 3″-deoxy analog 6 shows 5 times more potent activity than cADPcR, but the 2″,3″-didieoxy-2″,3″-unsunsaturated analog 3 has very weak activity. We also calculated their stable conformation and found that 3 and 6 were significantly different in their stable conformation.     

稻田土壤－作物－家畜系统中氮的循环研究

本文用Ｎ＾１５标记水稻和绿肥研究了稻田土壤－作物－家畜系统中氮的循环。Ｎ＾１５标记稻草喂羊,羊体回收饲料稻草Ｎ３１．１６％,羊粪２８．２６％,羊尿５．７２％,总回收６５．１４％,损失３４．８６％。将羊粪尿单施,稻谷回收饲料稻草Ｎ３．１９％,水稻全株回收４．８２％,水稻全株回收４．８２％,土壤残留１９．００％,损失１０．１４％。故羊体,水稻及土壤残留共回收饲料稻草Ｎ５４．９８％。将羊粪与尿素配施,则     

河豚毒素和Cd2+对Zn2+诱发爆发波放电的影响

本文用微电极细胞内电位记录、通道阻断剂和放射性同位素等技术发现,锌离子可诱发爆发波放电(BD),钠通道阻断剂——河豚毒素对BD无效应,而钙通道阻断剂——Ca²⁺则可使BD消失,Cd²⁺可使[⁶⁵Zn²⁺]_i量减少。以上结果说明,Zn²⁺诱发BD的产生机理很可能是Zn²⁺代替Ca²⁺通过钙通道进入胞内引起的。     

活性氧清除剂和钙离子通道阻断剂对人淋巴细胞化学发光的效应

本文报道了活性氧(ROS)清除剂——苯甲酸钠、维生素C、甘露醇、L-组氨酸、过氧化氢酶和超氧化物歧化酶对Con A诱导的人外周血淋巴细胞化学发光(Ly-CL)均有抑制效应,提示人Ly-CL与ROS的生成有关,参与人Ly-CL的ROS类型有·OH、¹O₂、H₂O₂和O₂^-_·。钙通道阻断剂——Verapamil对人Ly-CL也有抑制效应,表明人Ly-CL依赖于人淋巴细胞内钙离子浓度的增加。     

INDUCTION OF ANTIVIRAL RESPONSE BY ELECTRIC PULSES

Antiviral activity was detected in porcine leukocytes obtained from animals killed in a slaughterhouse. The activity appeared in the supernatant immediately after the addition of Sendai virus, an intended interferon (IFN) inducer. Electroinduction appears to be responsible for the production of antiviral molecules in both porcine and human leukocytes. The macromolecule conferring the antiviral activity is sensitive to heat and pH 2.0 treatment. The preformed or electroinduced antiviral activity originating from porcine leukocytes was not neutralized by either anti-PoIFN-α or anti-PoIFN-γ. The substance involved differs from all known antiviral proteins in that it is not secreted spontaneously into the extracellular space. Its release requires intact and virulent Sendai virus as a trigger signal. Differences in antigenic properties and characteristics indicate that this is a new antiviral substance.     

ASSESSMENT OF LIPOSOME DELIVERY USING SCINTIGRAPHIC IMAGING

ABSTRACT

Scintigraphic imaging is a valuable tool for the development of liposome-based therapeutic agents. It provides the ability to non-invasively track and quantitate the distribution of liposomes in the body. Liposomes labeled with technetium-99 m (^99mTc) are particularly advantageous for imaging studies because of their favorable physical characteristics. Examples of how scintigraphic imaging studies have contributed to the evaluation and development of a variety of liposome formulations will be presented. These include liposomes for targeting processes with inflammation associated increased vascular permeability such as healing bone fractures and viral infections; liposomes for intraarticular delivery; and liposomes for delivery of agents to lymph nodes located in the extremities, the mediastinum and the peritoneum. Scintigraphic studies of liposome distribution are very informational and often suggest new drug delivery applications for liposomes.     

ARYL NUCLEOSIDE H-PHOSPHONATES AS A TOOL FOR INVESTIGATION OF STEREOSPECIFICITY DURING COUPLING

It was found that in stereoselective condensations of ribonucleoside 3′-H-phosphonates with alcohols, the major diastereomer of the produced H-phosphonate diesters is formed from the minor diastereomer of the intermediate phosphonic-pivalic anhydride.     

ENGINEERING A HIGH-YIELD GLUTATHIONE STRAIN OF Hansenula polymorpha USING ION BEAM IMPLANTATION

To generate an industrial strain of Hansenula polymorpha capable of yielding greater levels of glutathione (GSH), wild strain H. polymorpha DL-1 cells were mutated using a nitrogen ion beam, a novel mutagen. At an energy level of 20 keV and dose of 2.13 × 10¹⁶ ions/cm², H. polymorpha strain 28 (HP28) with a high-yield of GSH was screened. HP28 intracellular GSH levels reached 337.16 mg/L by ion beam implantation, 1.56 times greater than that of the wild type strain when the fermentation time was shortened from 48 hr to 42 hr, greatly improving efficiency and reducing the cost of industrial-scale production. The enhanced efficiency of HP28 is promising for GSH production from lignocellulosic materials. Therefore, the ion beam implantation would be a cost-effective alternative to the conventional mutation method for engineering yeast and improving its utility.