Post-consumer waste wood in attributive product LCA

Background  

In product life cycle assessment (LCA), the attribution of environmental interventions to a product under study is an ambiguous task. This is due to a) the simplistic modeling characteristics in the life cycle inventory step (LCI) of LCA in view of the complexity of our techno-economic system, and b) to the nontangible theoretical nature of the product system as a representation of the processes ‘causally’ linked to a product. Ambiguous methodological decisions during the setup of an LCI include the modeling of end-of-life scenarios or the choice of an allocation factor for the allocation of joint co-production processes. An important criterion for methodological decisions — besides the conformity with the relevant series of standards ISO 14 040 — is if the improvement options, which can be deduced from the LCI, are perceived by the decision-maker as to redirect the material flows at stake into more sustainable paths.     

Systems biology-defined NF-κB regulons, interacting signal pathways and networks are implicated in the malignant phenotype of head and neck cancer cell lines differing in p53 status

Background  

Aberrant activation of the nuclear factor kappaB (NF-κB) pathway has been previously implicated as a crucial signal promoting tumorigenesis. However, how NF-κB acts as a key regulatory node to modulate global gene expression, and contributes to the malignant heterogeneity of head and neck cancer, is not well understood.     

Variability and conservation in hepatitis B virus core protein

Background  

Hepatitis B core protein (HBVc) has been extensively studied from both a structural and immunological point of view, but the evolutionary forces driving sequence variation within core are incompletely understood.     

An eco-profile of thermoplastic protein derived from blood meal Part 1: allocation issues

Purpose  

A renewable thermoplastic called Novatein Thermoplastic Protein (NTP) has been developed from blood meal—a low-value by-product of the meat processing industry. The aim of this research was to develop a non-renewable energy and greenhouse gas emission eco-profile for cradle to gate production of NTP. Environmental impacts of supplying blood meal as a raw material were investigated using different allocation methods for farming and blood meal production. These included mass, economic, treating low-value by-products as waste and system expansion by substitution. In part 2, the entire system will be analysed on a cradle to gate basis and include the production of thermoplastic (NTP).     

A conceptual framework for impact assessment within SLCA

Purpose  

This paper aims at spelling out the area of protection (AoP), namely the general concept of human well-being and the impact categories in social life cycle assessment (SLCA). The applicability of the so-called capabilities approach—a concept frequently used for evaluating human lives—is explored. It is shown how the principles of the capabilities approach can be transferred to the impact assessment within SLCA.     

Normalization in EDIP97 and EDIP2003: updated European inventory for 2004 and guidance towards a consistent use in practice

Purpose  

When performing a life cycle assessment (LCA), the LCA practitioner faces the need to express the characterized results in a form suitable for the final interpretation. This can be done using normalization against some common reference impact—the normalization references—which require regular updates. The study presents updated sets of normalization inventories, normalization references for the EDIP97/EDIP2003 methodology and guidance on their consistent use in practice.     

Complex distribution of EFL and EF-1α proteins in the green algal lineage

Background  

EFL (or elongation factor-like) is a member of the translation superfamily of GTPase proteins. It is restricted to eukaryotes, where it is found in a punctate distribution that is almost mutually exclusive with elongation factor-1 alpha (EF-1α). EF-1α is a core translation factor previously thought to be essential in eukaryotes, so its relationship to EFL has prompted the suggestion that EFL has spread by horizontal or lateral gene transfer (HGT or LGT) and replaced EF-1α multiple times. Among green algae, trebouxiophyceans and chlorophyceans have EFL, but the ulvophycean Acetabularia and the sister group to green algae, land plants, have EF-1α. This distribution singles out green algae as a particularly promising group to understand the origin of EFL and the effects of its presence on EF-1α.     

The Lc3-synthase gene <Emphasis Type="Italic">B3gnt5</Emphasis>is essential to pre-implantation development of the murine embryo

Background  

Glycosphingolipids (GSL) are integral components of mammalian cell membranes that are involved in cell adhesion and cell signaling processes. GSL are subdivided into structural series, like ganglio-, lacto/neolacto-, globo- and isoglo-series, which are defined by distinct trisaccharide cores. The β1,3 N-acetylglucosaminyltransferase-V (B3gnt5) enzyme catalyzes the formation of the Lc3 structure, which is the core of lactoseries derived GSL.     

Modulation of transforming growth factor beta signalling pathway genes by transforming growth factor beta in human osteoarthritic chondrocytes: involvement of Sp1 in both early and late response cells to transforming growth factor beta

Introduction  

Transforming growth factor beta (TGFβ) plays a central role in morphogenesis, growth, and cell differentiation. This cytokine is particularly important in cartilage where it regulates cell proliferation and extracellular matrix synthesis. While the action of TGFβ on chondrocyte metabolism has been extensively catalogued, the modulation of specific genes that function as mediators of TGFβ signalling is poorly defined. In the current study, elements of the Smad component of the TGFβ intracellular signalling system and TGFβ receptors were characterised in human chondrocytes upon TGFβ1 treatment.     

Environmental performance of building materials: life cycle assessment of a typical Sicilian marble

Background, aim, and scope  

The building sector is strategically important for achieving sustainability. Therefore, the improvement of energy and environmental performances are relevant targets because precious building materials such as marble have a significant impact on the environment. The aim of this paper is an analysis of a typical Sicilian marble (Perlato di Sicilia) to evaluate its energy and environmental performance. Marble plays an important role in the economy of Italy and has a global market share of 58% in terms of exports. For the main production areas of marble, relevant environmental performance data are missing except for one region (Tuscany—Massa e Carrara province). Perlato di Sicilia, the main marble of Custonaci (Sicily), has never been analyzed previously.     

Transforming growth factor-β1 blocks the enhancement of tumor necrosis factor cytotoxicity by hyaluronidase Hyal-2 in L929 fibroblasts

Background  

Functional antagonism between transforming growth factor beta (TGF-β) and hyaluronidase has been demonstrated. For example, testicular hyaluronidase PH-20 counteracts TGF-β1-mediated growth inhibition of epithelial cells. PH-20 sensitizes various cancer cells to tumor necrosis factor (TNF) cytotoxicity by upregulating proapoptotic p53 and WW domain-containing oxidoreductase (WOX1). TGF-β1 blocks PH-20-increased TNF cytotoxicity. In the present study, the functional antagonism between TGF-β1 and lysosomal hyaluronidases Hyal-1 and Hyal-2 was examined.