Systems biology-defined NF-κB regulons, interacting signal pathways and networks are implicated in the malignant phenotype of head and neck cancer cell lines differing in p53 status |
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| Authors: | Bin Yan Guang Chen Kunal Saigal Xinping Yang Shane T Jensen Carter Van Waes Christian J Stoeckert and Zhong Chen |
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| Institution: | (1) Head and Neck Surgery Branch, NIDCD, National Institutes of Health, Bethesda, MD 20892, USA;(2) Department of Bioengineering, University of Pennsylvania, Smith Walk, Philadelphia, Pennsylvania 19104, USA;(3) Center for Bioinformatics, University of Pennsylvania, Guardian Drive, Philadelphia, Pennsylvania 19104, USA;(4) NIH-Pfizer Clinical Research Training Program Award, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA;(5) Department of Statistics, The Wharton School, University of Pennsylvania, Walnut Street, Philadelphia, Pennsylvania 19104, USA;(6) Department of Genetics, School of Medicine, University of Pennsylvania, Curie Boulevard, Philadelphia, Pennsylvania 19104, USA |
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| Abstract: | Background Aberrant activation of the nuclear factor kappaB (NF-κB) pathway has been previously implicated as a crucial signal promoting tumorigenesis. However, how NF-κB acts as a key regulatory node to modulate global gene expression, and contributes to the malignant heterogeneity of head
and neck cancer, is not well understood. |
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