中国局限蚊属局限蚊亚属一新种（双翅目：蚊科）

本文记述了从云南西北边睡独龙江河谷栗获的一新种局限蚊——张氏局限蚊Topmyia(Topomyia)zhangi sp.nov.并根据新种的特征与近缘种作了比较和讨论。新种的模式标本全部保存于云南流行病研究所。     

领蚊属一新种(双翅目:蚊科)

记述采自云南省西双版纳勐腊县境内竹筒积水领蚊亚属1新种,讨论了新种与近缘种的鉴别特征。模式标本存于云南省寄生虫防治所。     

阿蚊属一新种(双翅目:蚊科)

记述采自云南省西双版纳小勐伦竹筒积水内阿蚊属1新种,讨论了新种与近缘种的鉴别特征。模式种保存于云南省寄生虫病防治研究所。     

局限蚊属一新种(双翅目:蚊科)

记述采自云南省思茅市南岛河芭蕉叶腋积水内局限蚊1新种,讨论了新种与近缘种的鉴别特征。模式种保存于云南省寄生虫病防治所。     

领蚊属一新种（双翅目：蚊科）

记述采自云南省腾冲县竹筒积水内领蚊1新种,以采获地命名为腾冲领蚊Heizmannia(Heizmannia）tengchongensis sp.nov.,讨论了新种与近缘种的鉴别特征。模式标本保存于云南省疟疾防治研究所。     

云南局限蚊一新种（双翅目：蚊科）

本文记述采自西双版纳勐腊县,原始森林中的局限蚊属一新种,双叉局限蚊Ｔｏｐｏｍｙｉａ（Ｔｏｐｏｍｙｉａ）ｂｉｆｕｒｃａｔａ ｓｐ．ｎｏｖ．。新种主要特征是雄蚊抱肢端节在亚端部分为内、外两枝,与马来西亚产的Ｔｏｐｏｍｙｉａ（Ｔｏｐｏｍｙｉａ）ａｅｎｅａ Ｔｈｕｒｍａｎ,１９５０很相似,但新种外分枝端部具粗而长的刺毛,抱肢基节、阳茎、腹节Ⅸ背板等均有显著区别。     

中国蓝带蚊属一新种(双翅目,蚊科)

记述采自云南省景东县境内树洞积水中蓝带蚊属1新种,云南蓝带蚊Uranotaenia(Uranotaenia)yunnanensis sp.nov.,讨论了新种与相似种的鉴别特征.模式标本存于云南省寄生虫病防治所.     

杵蚊属一新种(双翅目,蚊科)

记述采自云南省思茅市江城县竹筒积水内杵蚊属1新种,自胸杵蚊Tripteroides(Rachionotomyia)palldothorax sp.nov.,对比了新种与近似种的鉴别特征.模式标本保存于云南省寄生虫病防治所.     

广西猫儿山滑菌蚊属二新种(双翅目:菌蚊科)

报道产于广西猫儿山的滑菌蚊属Ｌｅｉａ二新种,描述了新种的形态特征,并与近似种进行了比较。     

杵蚊一新种记述——双翅目:蚊科

新种杵蚊属杵蚊亚属,是我国首次记载的本亚属新种。 宽刺杵蚊Tripteroides(Rripteroides)latispinus新种(图1) 雌蚊 中型棕色蚊虫。头顶的大部、后头和头的两侧具平覆深褐色宽鳞,后部近头窍有少数黑色竖叉鳞;眼缘具银白鳞饰。唇基、触角,触须和喙暗色。触角梗节棕黄色,鞭节1内侧具少数淡色宽鳞。触须为喙的1/9长。喙长约为前足股节的1.2倍。前胸前背片平覆银白宽鳞;后背片棕黄色,上部具散生的平覆褐色宽鳞,下部光裸;侧板无鳞。中胸盾片一致平覆密致的棕色窄鳞;小盾片平覆褐色宽鳞;后背片光裸,暗褐色;侧背片光裸。气门鬃3—4根;前侧片上部黑色,气门下区有一个小白鳞簇;气门亚区、腹侧板上部和后下部、后侧片大部以及各足基节平覆银白宽鳞。翊:翅鳞暗色。足:暗色,各足股节前面都     

A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus (2019-nCoV) Potentially Related to Viral Transmissibility

正Dear Editor,In December 2019, a novel human coronavirus caused an epidemic of severe pneumonia(Coronavirus Disease 2019,COVID-19) in Wuhan, Hubei, China(Wu et al. 2020; Zhu et al. 2020). So far, this virus has spread to all areas of China and even to other countries. The epidemic has caused 67,102 confirmed infections with 1526 fatal cases     

Curcuminoids as inhibitors of thioredoxin reductase: A receptor based pharmacophore study with distance mapping of the active site

Curcumin is the yellow pigment of turmeric that interacts irreversibly forming an adduct with thioredoxin reductase (TrxR), an enzyme responsible for redox control of cell and defence against oxidative stress. Docking at both the active sites of TrxR was performed to compare the potency of three naturally occurring curcuminoids, namely curcumin, demethoxy curcumin and bis-demethoxy curcumin. Results show that active sites of TrxR occur at the junction of E and F chains. Volume and area of both cavities is predicted. It has been concluded by distance mapping of the most active conformations that Se atom of catalytic residue SeCYS498, is at a distance of 3.56 from C13 of demethoxy curcumin at the E chain active site, whereas C13 carbon atom forms adduct with Se atom of SeCys 498. We report that at least one methoxy group in curcuminoids is necessary for interation with catalytic residues of thioredoxin. Pharmacophore of both active sites of the TrxR receptor for curcumin and demethoxy curcumin molecules has been drawn and proposed for design and synthesis of most probable potent antiproliferative synthetic drugs.     

Comparative morphology of the carpel in the Liliaceae: Hewardieae, Petrosavieae, and Tricyrteae

The young pistils in the melanthioid tribes, Hewardieae, Petrosavieae and Tricyrteae, are uniformly tricarpellate and syncarpous. They lack raphide idioblasts. All are multiovulate, with bitegmic ovules. The Petrosavieae are marked by the presence of septal glands and incomplete syncarpy. Tepals and stamens adhere to the ovary in the Hewardieae and the Petrosavieae but not in the Tricyrteae. Two vascular bundles occur in the stamens of the Hewartlieae and Tricyrtis latifolia. Ventral bundles in the upper part of the ovary of the Hewardieae are continuous with compound septal bundles and placental bundles in the lower part. Putative ventral bundles occur in the alternate position in the Tricyrteae and putative placental bundles in the opposite. position in the Petrosavieae. The dichtomously branched stigma in each carpel of the Tricyrteae is supplied by a bifurcated dorsal bundle.     

Enterovirus 71 3C proteolytically processes the histone H3 N-terminal tail during infection

Highlights
1. The N-terminal tail of histone H3 is specifically cleaved during EV71 infection.
2. Viral protease 3C is identified as a protease responsible for proteolytically processing the N-terminal H3 tail.
3. Our finding reveals a new epigenetic regulatory mechanism for Enterovirus 71 in virus-host interactions.     

Detection of EBV and HHV6 in the Brain Tissue of Patients with Rasmussen’s Encephalitis

Rasmussen’s encephalitis (RE) is a rare pediatric neurological disorder, and the exact etiology is not clear. Viral infection may be involved in the pathogenesis of RE, but conflicting results have reported. In this study, we evaluated the expression of both Epstein-Barr virus (EBV) and human herpes virus (HHV) 6 antigens in brain sections from 30 patients with RE and 16 control individuals by immunohistochemistry. In the RE group, EBV and HHV6 antigens were detected in 56.7% (17/30) and 50% (15/30) of individuals, respectively. In contrast, no detectable EBV and HHV6 antigen expression was found in brain tissues of the control group. The co-expression of EBV and HHV6 was detected in 20.0% (6/30) of individuals. In particular, a 4-year-old boy had a typical clinical course, including a medical history of viral encephalitis, intractable epilepsy, and hemispheric atrophy. The co-expression of EBV and HHV6 was detected in neurons and astrocytes in the brain tissue, accompanied by a high frequency of CD8⁺ T cells. Our results suggest that EBV and HHV6 infection and the activation of CD8⁺ T cells are involved in the pathogenesis of RE.     

Perinatal Vertical Transmission of Chikungunya Virus in Ruili,a Town on the Border between China and Myanmar

正Dear Editor,Chikungunya virus (CHIKV), an arbovirus in the family of Togaviridae, genus Alphavirus, is transmitted by the A.aegyptii or A. albopictus mosquito, and causes disease in humans characterized by fever, rash, and arthralgia (Silva and Dermody 2017; Suhrbier 2019). It was first reported in 1953 in Tanzania, and caused only a few outbreaks and sporadic cases in Africa and Asia in last century. However, in the epidemic in 2004, CHIKV acquired mutations that conferred enhanced transmission by the A. albopictus mosquito(Schuffenecker et al. 2006). Since then, it has successively caused outbreaks in Africa, the Indian Ocean, South East Asia, the South America, and Europe (Zeller et al. 2016).     

Development of a Novel Reverse Transcription Loop-Mediated Isothermal Amplification Method for Rapid Detection of SARS-CoV-2

In conclusion, the novel visual RT-LAMP assay is a simple, rapid, and sensitive approach for detection of SARS-CoV-2, and it is ready for application in primary care and community hospitals or health care centers, and even patients' own houses in response to the current SARS-CoV-2 epidemic because the assay does not require sophisticated equipment and skilled personnel. Furthermore, it is also ready to be used in fields for screening samples from wild animals and environments to facilitate the identification of potential intermediate hosts that mediate the cross-species transmission of SARS-CoV-2 from bats to humans.