传染病模型的非线性积分方程非零解的唯一性

本文给出保证传染病模型非线性积分方积x(t)=integral from n=t-τto t f[s,x(s)]ds的非零周期解存在唯一的一组充分条件。     

广义Emden-Fowler微分方程的振动准则（英文）

本文运用广义Riccati变换和中值定理,讨论了广义Emden-Fowler方程(r(t)|z'(t)|~(α-1)z'(t))'+q(t)|x(σ(t))|~(β-1)x(σ(t))=0的振动性,其中z(t)=x(t)+p(t)x(τ(t)),β≥α0,得到了该方程存在振动解的充分条件,推广和改进了已有结果,并用实例给出了其应用.     

分布时滞双向神经网络的周期解的渐近稳定性

利用重合度连续定理和适当的李亚普诺夫泛函,研究了分布时滞双向神经网络xi^.(t)=-ai(t)xi(t) ∑j=1^m pj,(t)∫-∞^t hji(t-s)fj(yj(s))ds Ii(t),i=1,2……,n,yj^.(t)=-bj(t)yj(t) ∑i=1^n qij(t)∫-∞^t kij(t-s)gi(xi(s))ds Jj(t),j=1,2,…,m的周期解的存在性和渐近稳定性。     

一阶线性差分微分方程振动的充要条件及应用

本文的目的是建立一阶线性差分微分方程 (dx)/(dt)=-sum from i=1 to n p_i(t)x(t-i_x(t)) (1)的所有解关于θ振动的等价条件,然后把所得结果应用于生物自身调节反馈滞后型方程(dN(t))/(dt)=rN(t)[1-(N(t-i))/p] (2)的更一般形式     

二元神经网络模型概周期解的存在性

本文研究了两个神经元的神经网络模型y1(t)=-α1y1(t) f(y2(t-T1) -Г2)) J1(t),y2(t)=-α2y2(t) g(y1(t-T2)-Г1)) J2(t)概周期解的存在性,获得存在概周期解的充分条件。     

Willis环状脑动脉瘤模型的概周期解

运用构造Liapunov函数的方法，证明了一类非线性系统+(μ+f(x))x+αx-βx2+γx3+g(x)=Fcosωt+e(t)(其中α，β，γ，μ均为正数)，在一定条件下存在唯一的一致渐近稳定的概周期解     

带年龄结构的非线性共生模型的稳定性

在[1]中讨论了一般形式的非线性共生模型的稳定性,其中N_1(t)和N_2(t)分别表示 dN_1(t)/dt=f(N_1(t),N_2(t))N_1(t), dN_2(t)/dt=g(N_1(t),N_2(t))N_2(t) (1) t时刻种群1和2的个体总数。这里我们把这个模型按自然方式推广到带年龄结构的两种群共生模型 (?)+μp+f(N_1(t),N_2(t))P_i=0, p(0,t)=integral from n=0 to m_i b_i(r)p(r,t)dr, p_i(r,0)=p_0(r), N(t)=integral from n=0 to m_i p_i(r,t)dr,i=1,2。 (2)     

具状态依赖时滞单种群模型周期正解的存在性

用重合度论的连续性定理,本文获得如下具状态依赖时滞的单种群增长模型周期正解的存在性x(t)=x(t)[a(t)+b(t)xp(t-τ(t,x(t)))-c(t)xq(t-τ(t,x(t)))]这里a,b,c∈C((0,∞),R)是周期为ω(ω>0)的连续函数,且a>0,c>0.m,p,q为正整数且q>p.     

海北藏系绵羊种群结构及其出栏方案分季最优化的探讨

本文是作者以前(1984)最优化模型探讨的续篇。考虑到季节性草畜矛盾是藏系绵羊生产的重要限制,为弥补以前模型之不足,本文对该模型进行了扩充,构造了种群季节动态模型,并在此基础上,以各季能量收益总和最大为目标,以种群年间平衡态和各季牧草限制为约束条件,构造了分季最优化的线性规划模型。种群季动态模型形式为: N_(t,s)+1=A_sN(t,s)-B_sU_(t,s) S=1,2 N_(t+1,1)=A_sN_(t,s)-B_sU_(t,s) S=3分季最优化的线性规划模型为: Max Z=(sum from s=1 to 3 sum from i=1 to 7 C_(is)U_i~s)+(sum from s=1 to 3 sum from i=1 to 7 d_(is) N_i~s s.t.sum from i=1 to 7 g_(is) N_i~s≤G_s A_3N_3-B_3N_3=N_1 A_1N_1-B_1N_1=N_2 A_2N_2-B_2N_2=N_3在构造模型同时,本文阐明了分季模型同以前年模型的异同及其数学和生物学的结构关系。除了构造模型之外,本文还使用来源与上篇相同的数据,计算了藏系绵羊最优种群结构、最优出栏方案及收益,并把计算结果同上篇的计算结果作了比较。从本文计算结果及其比较看,以百分比表示的最优存栏种群结构和最优出栏方案同上篇结果完全一致,但存栏和出栏的最优只数及收益上比上篇计算结果低20%左右。这个比值是由于季节牧草不平衡和藏系绵羊本身特征,使各季牧草不能按需均分,从而有余有缺而形成的。因此,在季节限制下,上篇模型预测的存栏结构和出栏方案仍为最优,然而其最优羊只数不能完全实现。     

中立型时滞LOTKA—VOLTERRA系统解的稳定性和振动性

一、引言考虑中立型时滞Lotka-Volterra系统 (t)=N(t)[a_i-sum from j=1 to n b_(ij) N_i(t—τ_(ij))-sum from j=1 to n c_(ij) (t-σ_(ij))],i=1,2,…,n,(E)其中τ_(ij),σ_(ij)∈(0,∞),a,b_(ij),c_(ij)∈R,i,j=1,2,…,n,对正常数平衡点N~*的稳定性和振动性。由于系统(E)是描述种群所组成的生态群落中种群之间互相作用的生态     

Curcuminoids as inhibitors of thioredoxin reductase: A receptor based pharmacophore study with distance mapping of the active site

Curcumin is the yellow pigment of turmeric that interacts irreversibly forming an adduct with thioredoxin reductase (TrxR), an enzyme responsible for redox control of cell and defence against oxidative stress. Docking at both the active sites of TrxR was performed to compare the potency of three naturally occurring curcuminoids, namely curcumin, demethoxy curcumin and bis-demethoxy curcumin. Results show that active sites of TrxR occur at the junction of E and F chains. Volume and area of both cavities is predicted. It has been concluded by distance mapping of the most active conformations that Se atom of catalytic residue SeCYS498, is at a distance of 3.56 from C13 of demethoxy curcumin at the E chain active site, whereas C13 carbon atom forms adduct with Se atom of SeCys 498. We report that at least one methoxy group in curcuminoids is necessary for interation with catalytic residues of thioredoxin. Pharmacophore of both active sites of the TrxR receptor for curcumin and demethoxy curcumin molecules has been drawn and proposed for design and synthesis of most probable potent antiproliferative synthetic drugs.     

A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus (2019-nCoV) Potentially Related to Viral Transmissibility

正Dear Editor,In December 2019, a novel human coronavirus caused an epidemic of severe pneumonia(Coronavirus Disease 2019,COVID-19) in Wuhan, Hubei, China(Wu et al. 2020; Zhu et al. 2020). So far, this virus has spread to all areas of China and even to other countries. The epidemic has caused 67,102 confirmed infections with 1526 fatal cases     

Comparative morphology of the carpel in the Liliaceae: Hewardieae, Petrosavieae, and Tricyrteae

The young pistils in the melanthioid tribes, Hewardieae, Petrosavieae and Tricyrteae, are uniformly tricarpellate and syncarpous. They lack raphide idioblasts. All are multiovulate, with bitegmic ovules. The Petrosavieae are marked by the presence of septal glands and incomplete syncarpy. Tepals and stamens adhere to the ovary in the Hewardieae and the Petrosavieae but not in the Tricyrteae. Two vascular bundles occur in the stamens of the Hewartlieae and Tricyrtis latifolia. Ventral bundles in the upper part of the ovary of the Hewardieae are continuous with compound septal bundles and placental bundles in the lower part. Putative ventral bundles occur in the alternate position in the Tricyrteae and putative placental bundles in the opposite. position in the Petrosavieae. The dichtomously branched stigma in each carpel of the Tricyrteae is supplied by a bifurcated dorsal bundle.     

鸡传染性法氏囊病病毒研究进展

传染性法氏囊病(Infection bursal disease, IBD)是由鸡传染性法氏囊病毒(Infectious bursal disease virus, IBDV)引起的鸡和火鸡的一种高度接触性传染病,给世界各国的禽养殖业带来了巨大损失.自IBDV发现至今新的变异株不断出现,分子结构的改变导致病毒致病力的改变及宿主对疫苗应答的改变,使得传统的疫苗已不能控制其流行,因此各国学者对其基因组结构和功能进行了广泛深入的研究,并积极研制新型有效的疫苗以达到防治的目的.     

Development of a Novel Reverse Transcription Loop-Mediated Isothermal Amplification Method for Rapid Detection of SARS-CoV-2

In conclusion, the novel visual RT-LAMP assay is a simple, rapid, and sensitive approach for detection of SARS-CoV-2, and it is ready for application in primary care and community hospitals or health care centers, and even patients' own houses in response to the current SARS-CoV-2 epidemic because the assay does not require sophisticated equipment and skilled personnel. Furthermore, it is also ready to be used in fields for screening samples from wild animals and environments to facilitate the identification of potential intermediate hosts that mediate the cross-species transmission of SARS-CoV-2 from bats to humans.     

Perinatal Vertical Transmission of Chikungunya Virus in Ruili,a Town on the Border between China and Myanmar

正Dear Editor,Chikungunya virus (CHIKV), an arbovirus in the family of Togaviridae, genus Alphavirus, is transmitted by the A.aegyptii or A. albopictus mosquito, and causes disease in humans characterized by fever, rash, and arthralgia (Silva and Dermody 2017; Suhrbier 2019). It was first reported in 1953 in Tanzania, and caused only a few outbreaks and sporadic cases in Africa and Asia in last century. However, in the epidemic in 2004, CHIKV acquired mutations that conferred enhanced transmission by the A. albopictus mosquito(Schuffenecker et al. 2006). Since then, it has successively caused outbreaks in Africa, the Indian Ocean, South East Asia, the South America, and Europe (Zeller et al. 2016).     

Enterovirus 71 3C proteolytically processes the histone H3 N-terminal tail during infection

Highlights
1. The N-terminal tail of histone H3 is specifically cleaved during EV71 infection.
2. Viral protease 3C is identified as a protease responsible for proteolytically processing the N-terminal H3 tail.
3. Our finding reveals a new epigenetic regulatory mechanism for Enterovirus 71 in virus-host interactions.