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1.
Ertan Delilbaşi Belma Turan Ertan Yücel Rüstem Şaşmaz Aşkin Işimer Ahmet Sayal 《Biological trace element research》1991,28(1):21-25
Behçet's disease is an inflammatory disorder of unknown etiology, characterized by recurrent oral and genital aphthous ulcers, ocular inflammation, and skin lesions of erythema nodusum and acneiformeruptions. Selenium (Se) affects all components of the immune system, i.e., the development and expression of nonspecific, humoral, and cell-mediated responses. In general, a deficiency in Se appears to result in immunosuppression, whereas supplementation with low doses of Se appears to result in augmentation and/or restoration of immunoglogic functions. In this study, the distribution of Se and IgG, IgM in serum were compared in samples from healthy adult control and Behçet's disease patients. The serum Se levels were measured by AA-30-40 Varian Spectra, and immunoglobulins were measured by immunodiffusion technique. The mean (SD) serum Se level of 54.24 ± 8.06 ng/mL among Behçet's disease subjects was significantly different (P<0.01) from that in the control subjects (90.01 ± 9.94 ng/mL). We also measured IgG and IgM as 10.01 ± 2.74 mg/mL and 1.26 ± 0.29 mg/mL, respectively for patients, and 15.08 ± 4.73 mg/mL and 1.58 ± 0.43 mg/mL for controls. The mean values of IgG and IgM for patients were significantly (P<0.05) different from the values of controls. It seems, therefore, that a deficiency in selenium impedes the humoral immune response. 相似文献
2.
Andreas S. Mueller Kristin Mueller Nicole M. Wolf Josef Pallauf 《Free radical research》2013,47(11):1029-1059
In recent years diabetes has become one of the most common metabolic diseases in developed countries and it is closely related to supernutrition and obesity. Since untreated diabetes produces oxidative stress responsible for secondary complications of the disease, antioxidant supplements were considered as being favourable for the therapy of diabetes. However, the situation has changed recently, since large cross-sectional and interventional trials revealed a positive correlation between a high Se status and diabetes incidence in humans. Thus, currently available data on the role of Se in diabetes are inconsistent and an enigma appears to exist for the relation between selenium and diabetes. This review summarizes selected human and animal studies, pointing to beneficial and critical virtues of Se in diabetes. Moreover, the review discusses possible underlying mechanisms how Se may influence diabetes in both directions. From the current literature, the following information can be extracted: (1) In populations with a high Se status, with the single exception of pregnant women, Se supplements cannot be recommended for the prevention of diabetes; (2) Anti-diabetic effects of Se seem to be restricted to high and nearly toxic doses which cannot be used in humans; and (3) Future investigations should consider the stage of the disease. 相似文献
3.
Selenium–Mercury Interactions in Man and Animals 总被引:4,自引:0,他引:4
Selenium–mercury interactions were most extensively studied in relation to alleviation of Hg toxicity by added selenium. This
presentation considers the influence of mercury on endogenous selenium, on its tissue and cellular “status” after lifelong
or acute exposure to mercury vapor (Hgo). Discussed are data obtained from (1) humans living near or working in a mercury mine, and (2) rats experimentally exposed
in the mine. Mercury vapor is unique—or similar to methylmercury—because of its ability to penetrate cell membranes and so
invade all cells, where it is oxidized in the biologically active form (Hg++) by catalase. Such in situ-generated ions can react with endogenously generated highly reactive Se metabolites, like HSe−,
and render a part of the selenium unavailable for selenoprotein synthesis. Data on human populations indicate that in moderate
Hg exposure combined with an adequate selenium supply through diet, Se bioavailability can be preserved. On the other hand,
the results of an acute exposure study emphasize the dual role of selenium in mercury detoxification. Besides the well-known
Se coaccumulation through formation of nontoxic Hg–Se complexes, we observed noticeable Se (co)excretion, at least at the
beginning of exposure. The higher Hg accumulation rate in the group of animals with lower basal selenium levels can also point
to selenium involvement in mercury excretion. In such conditions there is a higher probability for decreased selenoprotein
levels (synthesis) in some tissues or organs, depending on the synthesis hierarchy. 相似文献
4.
M. Djanaguiraman D. Durga Devi Arun K. Shanker J. Annie Sheeba U. Bangarusamy 《Plant and Soil》2005,272(1-2):77-86
Selenium (Se) is regarded as an antioxidant in animals and plants, even though considered as non-essential element in plants. To test its ability to counteract senescence related oxidative stress in soybean a pot culture experiment was conducted. The soybean plant was sprayed with sodium selenate (50ppm) at 78days after sowing (DAS). Soybean leaves were harvested at 80 and 90 DAS for analysis of oxidant production and antioxidative enzymes activity. Se positively promoted growth and acted as antioxidant by inhibiting lipid peroxidation and per cent injury of cell membrane. The antioxidative effect was associated with an increase in superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) enzymes activity. Significant increase in antioxidant enzyme activity was positively related to Se content. The decrease in antioxidative enzymes at 90 DAS was much faster in control plants than Se-sprayed plants. The reduction in SOD and GSH-Px may be associated with senescence-induced oxidative burst. 相似文献
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7.
Apryatina K. V. Murach E. I. Amarantov S. V. Erlykina E. I. Veselov V. S. Smirnova L. A. 《Applied Biochemistry and Microbiology》2022,58(2):126-131
Applied Biochemistry and Microbiology - A biologically active composition of chitosan-selenium nanoparticles has been developed. Selenium nanoparticles are characterized by a clear bimodal size... 相似文献
8.
Selenium intake and cardiovascular risk: what is new? 总被引:1,自引:0,他引:1
PURPOSE OF REVIEW: Selenium is an essential element with a narrow safety margin. Adequate selenium intake is needed to maximize the activity of glutathione peroxidases and other selenoproteins. This review discusses recent experimental and epidemiologic contributions on the role of selenium for the prevention of atherosclerotic cardiovascular disease. RECENT FINDINGS: Few randomized trials have evaluated the efficacy of selenium supplementation on cardiovascular endpoints. Most trials, conducted in selenium-replete populations, found no evidence of cardiovascular protection. A meta-analysis of 13 prospective cohort studies found a moderate inverse relationship between plasma/serum selenium and coronary heart disease. The interpretation of these data is complicated, however, by potential residual confounding and publication bias. In contrast, recent data from trials of selenium-containing supplements and from epidemiologic studies suggest that chronically increased selenium intake in selenium-replete populations can induce diabetes and maybe also hypercholesterolemia. SUMMARY: Current evidence is insufficient to support a protective role for selenium in cardiovascular prevention. Large high-quality randomized controlled trials and observational studies are needed across populations with different levels of selenium intake. Furthermore, subjects living in regions with high selenium intake should be aware that selenium supplements may increase their risk of diabetes and hypercholesterolemia. 相似文献
9.
Nouran Abd-ElMoemen Ahmed Menshawy Ahmed Negida Marwa Alaa El-Din Ahmed Kamel Alaa Ehab Farouk 《International journal of peptide research and therapeutics》2016,22(1):135-141
One of the current international public health emergencies is the outbreak of Ebola virus disease (EVD), requiring extraordinary response. The current outbreak in West Africa is the most dangerous since Ebola was first discovered on 26 August 1976. Till January 6th 2015, It resulted in 13,387 laboratory confirmed human cases and 8274 deaths. Ebola virus has 5 strains, 4 are pathogenic in humans while the 5th strain Ebola reston strain is not. The current outbreak is caused by Ebola most pathogenic strain, Ebola Zaire strain whose genome differs from that of Reston Ebola virus strain, by the existence of several open reading frames containing large numbers of UGA codons. These codons act as stop codons and in addition they may encode for Selenocysteine, the 21st aminoacid, which is essential for the formation of Selenoproteins. Selenoproteins are integral to the metabolism and have been linked to the progression of certain viral diseases. In this review, we discuss the relation between Selenium and the progression of the current EVD in Africa supported by geographical distribution of Se and genetic evidence. 相似文献
10.
Yasuji Hojo 《Biological trace element research》1982,4(2-3):233-239
Samples of raw or pasteurized cow’s milk and infant formula were assayed for glutathione peroxidase (GSH-Px) activity, selenium
(Se), and total protein. GSH-Px activity was detected in raw milk, but not in market-pasteurized milk or infant formula. The
correlation between GSH-Px activity and Se levels was significant, even when the influence of protein level was removed. This
result implies a role of GSH-Px as one of biologically active forms of Se in raw milk. Absence of GSH-Px activity in pasteurized
milk and infant formula result from the heating process in these productions, because the heating of raw milk gave an irreversible
inactivation of GSH-Px. Both GSH-Px activity and Se levels had significant correlation with protein level, but not so when
the respective influences of Se and GSH-Px levels were removed. In raw cow’s milk, Se content was 23 ng/mL and GSH-Px activity
was 20 U/mL. About 12% of Se was bound to GSH-Px, and 0.003% of protein was GSH-Px. Raw milk obtained in July contained higher
levels of Se, GSH-Px, and protein than that in November. Data for cow’s milk were discussed in relation to those for human
milk and those in New Zealand. 相似文献
11.
Diabetes is one of the leading causes of death in developed and developing countries. Oxidative stress has been proposed to play a crucial role in the pathogenesis of diabetic vascular complications. In recent years, selenium has been shown to mediate a number of insulinlike actions in a dose-dependent fashion both in vitro and in vivo. In this study, the effect of selenium as sodium selenite was investigated in streptozotocin-induced diabetic rats at the dose of 1?μg sodium selenite/kg body weight. Selenium supplementation restored the streptozotocin-induced alterations in the activities of antioxidant enzymes, decreased the serum glucose level, glycated hemoglobin content as well as the levels of lipid peroxidation products, and downregulated the expressions of both NFkB and RAGE. The histopathological studies also reinforce our findings. Hence, selenium has a protective role in streptozotocin-induced diabetes mellitus. 相似文献
12.
Yao YF Pei FX Li XB Yang J Shen B Zhou ZK Li L Kang PD 《Biological trace element research》2012,146(2):199-206
The purpose of this study was to investigate the effects of supplemental selenium and selenium plus iodine on bone and growth
plate cartilage histology and serum biochemistic parameters in rats. Ninety-six Wistar rats were randomly divided into the
following four groups: group A, the rats fed with normal diet; group B, fed with diet from Kashin–Beck disease (KBD) endemic
area; group C, fed with diet from KBD endemic area supplemented with selenium; and group D, fed with diet from KBD endemic
area supplemented with selenium and iodine. After 4, 8, and 12 weeks, bone and cartilage samples were collected from the rats
and were examined for morphological changes in the tibial growth zone and for changes in the plate cartilage and metaphysic.
Compared to the rats fed with diet from the KBD endemic area, the rats fed with the supplemental selenium or selenium plus
iodine exhibited diminished necrosis of the chondrocytes in the growth plate. In the groups of rats receiving supplemental
selenium and selenium plus iodine, the bone volume/tissue volume ratio (BV/TV), the trabecular thickness (Tb.Th), and the
trabecular number were increased, while the trabecular separation was decreased. In the 12th week of the experiment, BV/TV
and Tb.Th were significantly increased in the selenium plus iodine group compared to the selenium group. It is concluded that
feeding the diet from the KBD endemic area caused necrosis of chondrocytes and dysfunctions of bone development similar to
the pathological changes that are seen in KBD. Selenium and iodine protected chondrocytes in growth plate and promoted the
formation of trabecular bone. The effects of selenium plus iodine on bone formation were more obvious than those of selenium
alone 相似文献
13.
Gabriela Lorea Godoi Lisiane de Oliveira Porciúncula Janaína Fagundes Schulz Fernanda Neutzling Kaufmann João Batista da Rocha Diogo Onofre Gomes de Souza Gabriele Ghisleni Hiram Larangeira de Almeida Jr. 《Neurochemical research》2013,38(11):2359-2363
Neuropathological hallmarks of Alzheimer’s disease (AD) include amyloid plaque formation, neurofibrillary tangles, neuronal and synaptic loss. This study aims to identify the neuroprotective effects of the selenium compounds on the neurotoxicity of amyloid β(1–42) in primary cultures of murine hippocampal neurons. Samples were subjected to immunocytochemistry and western blotting techniques to determine the role of treatments on neuronal viability and synaptic protein SNAP-25. We observed a reduced cell viability amyloid β-peptide (1–42)-induced. When cells were co-treated with amyloid β-peptide (1–42) and selenium compounds, we verified a strong increase in relative cell viability and in the level of synaptic marker synaptosomal-associated protein SNAP-25 induced by selenium compounds. 相似文献
14.
Hou J Wang T Liu M Li S Chen J Liu C Zhang H Wang Y Liu Z Liang N Wan Y Li Q Sun S Zhang L Feng H Liu Y Wang H 《Biological trace element research》2011,143(3):1255-1263
This study explores whether the declining prevalence of Keshan disease is associated with increasing selenium levels in Keshan disease areas in Heilongjiang province. Six counties endemic with Keshan disease and three non-endemic counties were selected as study areas. In each county, two townships and in each township one village were chosen in which to survey ten families about head hair, grain, and soil samples and to obtain demographic information. Selenium was measured with hydride generation-atomic fluorescence spectrometry. In each county endemic with Keshan disease, one of the villages was chosen to investigate the prevalence of the disease. We collected 534 head hair samples, 446 staple food samples, and 180 soil samples. The selenium levels of head hair and corn in the endemic counties were significantly lower than those in non-endemic counties. Family demographic information was homologous except for the composition of staple food. More residents in Keshan disease areas preferred flour and corn. The detection rate for latent Keshan disease had a significantly negative correlation with the corn selenium level in six counties endemic with Keshan disease. As the population in this region is still at risk for Keshan disease, selenium surveillance measures should be intensified. 相似文献
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16.
Lindberg P. Tanhuanpää E. Schulman A. Garry-Andersson A.-S. 《Acta veterinaria Scandinavica》1972,13(2):238-241
Mean selenium contents of liver, heart muscle and skeletal muscle of pigs with dietetic microangiopathy (MAP), but without waxy muscle degeneration (MD) and hepatosis diaetetica (HD), were 1113, 850 and 265 ng/g d.s., respectively. These values were not lower than corresponding values of control pigs without MAP, MD and HD. 相似文献
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18.
Hakkarainen Juhani Lindberg Paul Bengtsson Gösta Jönsson Lennart 《Acta veterinaria Scandinavica》1978,19(2):285-297
By using a therapeutic dietary supplementation in pigs, which had developed the vitamin Ε and selenium deficiency (VESD) syndrome, the same amounts of α-tocopheryl acetate and selenium were found to be effective as under prophylactic conditions. The experiment thus supported the conclusions that the addition of 5 mg DL-α-tocopheryl acetate/kg and 135 μg selenium/kg to a diet, which contained only traces of vitamin Ε and selenium, represents a level of minimal requirement. Glutathione peroxidase activity in blood serum was used to evaluate the selenium status in pigs. A modified method for determination of tocopherol in fat tissue was described. The addition of 15 mg α-tocopheryl acetate/kg diet was demonstrated to be sufficient to maintain the tocopherol stores in body fat at an unchanged level. 相似文献
19.
Yujie Ning Xi Wang Xiong Guo Pan Zhang Pengfei Qu Feng Zhang Sen Wang Yanxia Lei Mikko Lammi 《Biological trace element research》2018,183(2):233-244
Overall nutritional status has been proved associated with people’s health. The overall nutritional status of children in Kashin-Beck disease (KBD) areas has been overlooked for decades. Therefore, it is worth investigating in the current generation to gather evidence and make suggestions for improvement. A cross-sectional study with three 24-h dietary recalls was conducted to collect raw data on the daily food intake of children. Recorded food was converted into daily nutrient intakes using CDGSS 3.0 software. WHO AnthroPlus software was used to analyse the BMI-for-age z-score (BAZ) for estimating the overall nutrition status of children. All the comparisons and regression analyses were conducted with SPSS 18.0 software. Multiple nutrient intakes among children from the Se-supplemented KBD-endemic were under the estimated average requirement. The protein-to-carbohydrate ratio (P/C ratio) was significantly higher in children from the non-Se-supplemented KBD-endemic area than the other areas (P < 0.001). The children’s BAZ was negatively associated with age (B = ?0.095, P < 0.001) and the number of KBD relatives (B = ?0.277, P = 0.04), and it was positively associated with better housing conditions, receiving colostrum, and daily intakes of niacin and zinc by multivariate regression analysis (F = 10.337, R = 0.609, P < 0.001).Compared to non-Se-supplemented KBD-endemic area and non-endemic areas, children in Se-supplemented KBD-endemic areas have an insufficient intake of multiple nutrients. School breakfast and lunch programmes are recommended, and strict implementation is the key to ensuring a positive effect. 相似文献
20.
Selenium concentration in wheat grain: Is there sufficient genotypic variation to use in breeding? 总被引:8,自引:0,他引:8
Graham Lyons Ivan Ortiz-Monasterio James Stangoulis Robin Graham 《Plant and Soil》2005,269(1-2):369-380
Selenium (Se) is an essential micronutrient for humans and animals, with antioxidant, anti-cancer and anti-viral effects,
and wheat is an important dietary source of this element. In this study, surveys of Se concentration in grain of ancestral
and wild relatives of wheat, wheat landrace accessions, populations, and commercial cultivars grown in Mexico and Australia
were conducted. Cultivars were also grown under the same conditions to assess genotypic variation in Se density. Eleven data
sets were reviewed with the aim of assessing the comparative worth of breeding compared with fertilising as a strategy to
improve Se intake in human populations. Surveys and field trials that included diverse wheat germplasm as well as other cereals
found grain Se concentrations in the range 5–720μgkg−1, but much of this variation was associated with spatial variation in soil selenium. This study detected no significant genotypic
variation in grain Se density among modern commercial bread or durum wheat, triticale or barley varieties. However, the diploid
wheat, Aegilops tauschii and rye were 42% and 35% higher, respectively, in grain Se concentration than other cereals in separate field trials, and,
in a hydroponic trial, rye was 40% higher in foliar Se content than two wheat landraces. While genotypic differences may exist
in modern wheat varieties, they are likely to be small in comparison with background soil variation, at least in Australia
and Mexico. Field sites that are spatially very uniform in available soil Se would be needed to allow comparison of grain
Se concentration and content in order to assess genotypic variation. 相似文献