共查询到20条相似文献,搜索用时 15 毫秒
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Kingsley-Kallesen ML Kelly D Rizzino A 《The Journal of biological chemistry》1999,274(48):34020-34028
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Hormonal regulation of lactate dehydrogenase-A through activation of protein kinase C pathways in MCF-7 breast cancer cells 总被引:3,自引:0,他引:3
Li X Qin C Burghardt R Safe S 《Biochemical and biophysical research communications》2004,320(3):625-634
Lactate dehydrogenase A (LDH-A) is hormonally regulated in rodents, and increased expression of LDH-A is observed during mammary gland tumorigenesis. The mechanisms of hormonal regulation of LDH-A were investigated using a series of deletion and mutant constructs derived from the rat LDH-A gene promoter. Results of these studies show that constructs containing the -92 to -37 region of the LDH-A promoter are important for basal and E2-induced transactivation, and mutation of the consensus CRE motif within this region results in significant loss of basal activity and hormone-responsiveness. Gel mobility shift assays using nuclear extracts from MCF-7 cells show that both CREB and ATF-1 interact with the CRE. Studies with kinase inhibitors show that E2-induced activation of this CRE is dependent on protein kinase C, and these data indicate that LDH-A is induced through a non-genomic pathway of estrogen action. 相似文献
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A CRE/ATF-like site in the upstream regulatory sequence of the human interleukin 1 beta gene is necessary for induction in U937 and THP-1 monocytic cell lines. 下载免费PDF全文
J G Gray G Chandra W C Clay S W Stinnett S A Haneline J J Lorenz I R Patel G B Wisely P J Furdon J D Taylor et al. 《Molecular and cellular biology》1993,13(11):6678-6689
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