Seminal inhibin--prospects for immunocontraception.

Passive immunization of adult rats, hamsters and marmosets with rabbit anti-seminal inhibin resulted in complete or partial block of fertility. The antiserum treatment presumably neutralized endogenous inhibin resulting in an unopposed rise in circulating FSH. This probably led to a refractoriness of the testes to FSH resulting in complete spermatogenic arrest. Nevertheless, there was no change in the mating behaviour of the animals. The antibodies also affected the epididymal spermatozoa by causing large scale agglutination.     

Seminal plasma gamma-glutamyltransferase activity and fertility.

The γ-glutamyltransferase activity of human seminal plasma does not correlate with the usual laboratory indicators of fertility. Overlapping enzyme activities in euspermic samples and aspermic post-vasectomy specimens probably excludes both sperm and epididymis as the major sources of the seminal plasma enzyme.     

不育男性精浆锌与其它精液参数的回归分析

对２２３例男性不育患者的精浆锌进行了测定,并用回归分析的方法研究了精浆锌与其它精液参数的关系．结果显示：精浆锌与精液ｐＨ、精子存活率之间存在显著的线性回归（Ｐ＜０．０１）,而精浆锌与精子密度、前向运动精子百分率、精子畸型率具有显著的曲线回归（Ｐ＜０．０１）．     

精囊镜联合非那雄胺治疗慢性精囊炎反复血精的疗效分析

目的:探讨精囊镜联合非那雄胺治疗慢性精囊炎反复血精的临床有效性及安全性。方法:2012年1月至2014年8月于我院住院治疗患者中选取慢性精囊炎反复血精患者62例,应用随机数字表法,其中实验组31例,采取精囊镜联合非那雄胺治疗,对照组31例,采取单纯精囊镜手术治疗。对比两组患者有效率、复发率、症状改善及精浆果糖改善情况。结果:62例慢性精囊炎反复血精患者均顺利完成手术。实验组有效率96.77%、复发率10%,对照组有效率64.52%、复发率50%,两组比较差异有统计学意义;两组患者治疗后精浆果糖均显著升高,实验组升高程度更为明显(P0.05);实验组患者症状如会阴及下腹部不适、尿道烧灼感、性欲减退、早泄及头晕四肢乏力改善(90.32%)明显好于对照组(64.52%),差异有统计学意义。结论:精囊镜联合非那雄胺治疗慢性精囊炎反复血精安全、有效,值得临床上推广应用。     

The Transurethral Seminal Vesiculoscopy in the Diagnosis and Treatment of the Seminal Vesicle Disease

To develop a transurethral endoscopy technique of the transurethral seminal vesiculoscopy to examine and treat seminal vesicle disease. A total of 61 patients with seminal vesicle disease were diagnosed and treated with the transurethral seminal vesiculoscopy through the distal seminal tracts and vesicles. 58 cases were successfully treated using transurethral seminal vesiculoscopy via the seminal vesicles. The operation took 25 ~ 85 min, with an average of (35.6) mins. In this group, seven cases were diagnosed as ejaculatory orifice cyst, 14 cases had blood clots in the seminal vesicles, and nine patients had stones in the seminal vesicles. All patients were treated properly. Follow-up occurred at 3 months, with two cases showing post-operative discomfort in perineal region. One patient had recurrence with seminal vesiculitis, which improved with treatment. Four infertile patients had a significant increase in sperm count and ejaculation volume and two of these patients were able to naturally inseminate within seven to 18 months post-surgery. This approach enables a new endoscopic technique with the transurethral seminal vesiculoscopy to diagnose and treat seminal vesicle disease through the normal anatomic pathway which can be easily performed with few post-operative complications.     

Seminal fluid excretion of cytomegalovirus related to immunosuppression in homosexual men.

Seminal fluid samples from 84 Danish homosexual men were successfully cultured to determine the prevalence of cytomegalovirus excretion. Ten (15%) out of 66 men positive for the antibody were found to be excreting the virus. Although the proportion excreting was inversely related to age (p less than 0.01), three men aged over 30 and with many years of homosexual experience excreted the virus. In addition, a 50 year old man with Kaposi''s sarcoma excreted the virus. A further study of the ratio of T cell helpers to suppressors in the men aged over 30 and a series of age matched non-excreting homosexual control or heterosexual men showed that those excreting cytomegalovirus in their seminal fluid had statistically lower ratios (all less than 0.77) than the controls (p less than 0.05). Excretion of cytomegalovirus may be related to re-emergence of latent infection in immunosuppressed homosexual men.     

Seminal vesicle production and secretion of growth hormone into seminal fluid.

Production of foreign proteins in the tissues of transgenic animals represents an efficient and economical method of producing therapeutic and pharmaceutical proteins. In this study, we demonstrate that the mouse P12 gene promoter specific to the male accessory sex gland can be used to generate transgenic mice that express human growth hormone (hGH) in their seminal vesicle epithelium. The hGH is secreted into the ejaculated seminal fluids with the seminal vesicle lumen contents containing concentrations of up to 0.5 mg/ml. As semen is a body fluid that can be collected easily on a continuous basis, the production of transgenic animals expressing pharmaceutical proteins into their seminal fluid could prove to be a viable alternative to use of the mammary gland as a bioreactor.     

Selenium,Copper and Zinc in Seminal Plasma of Men with Varicocele,Relationship with Seminal Parameters

Varicocele has been associated with decrease in seminal parameters. Selenium (Se), copper (Cu), and zinc (Zn) are trace elements essential for normal spermatogenesis of mammals and play a critical role as antioxidant defense system enzymes. Se, Cu, and Zn are associated with sperm quality in fertile and infertile men. However, there is little information about Se, Cu, and Zn concentrations in semen in patients with varicocele and its association with seminal parameters. The purpose of this study was to determine the concentrations of Se, Cu, and Zn in semen of patients with varicocele and the relationship with seminal parameters. Total Reflection X-Ray Fluorescence was used for the fist time in the seminal fluid analysis. The concentration of selenium in men with varicocele was smaller than the normozoospermic group, while no differences were observed for both concentrations of zinc and copper. A significant positive correlation between zinc and selenium concentration was observed. Selenium in seminal plasma correlates with a good spermatozoa concentrations, motility, and morphology. Additionally, a significant positive correlation was observed between zinc levels and sperm count. In conclusion, a decrease in selenium concentration was associated with detriment of seminal parameters. A study should be conducted to evaluate the benefits of both zinc and selenium supplementation to improve seminal parameters in patients with varicocele.     

Seminal plasma,an unnecessary evil?

Despite considerable activity in the field of semen biochemistry over the last thirty years no generalization about the function of the myriad of seminal plasma constituents has emerged. As a result, some have commented, if not in print, that the seminal plasma has no essential function at all. The present paper examines the literature in the light of the premise that the answer to the question of the role of seminal plasma constituents will require an overall view of each species' reproductive physiology as it relates to such events and processes as gamete production, copulation, gamete transport and the environment within the female tract. Guidelines are suggested that should be followed when attempting to suggest a role or roles for seminal constituents.