Selenium,Copper and Zinc in Seminal Plasma of Men with Varicocele,Relationship with Seminal Parameters |
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Authors: | María Isabel Camejo Lyzeth Abdala Giovanny Vivas-Acevedo Ricardo Lozano-Hernández Miriam Angeli-Greaves Eduardo D Greaves |
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Institution: | 1.Departamento de Biología de Organismos,Universidad Simón Bolívar,Baruta,Venezuela;2.Departamento de Física,Universidad Simón Bolívar,Baruta,Venezuela;3.Centro Diagnóstico de Infertilidad y Enfermedades Genéticas (CEDIEG), Departamento de Bioanálisis Clínico,Universidad de Los Andes,Mérida,Venezuela;4.Cátedra de Farmacología, Facultad de Medicina,Universidad Central de Venezuela,Caracas,Venezuela |
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Abstract: | Varicocele has been associated with decrease in seminal parameters. Selenium (Se), copper (Cu), and zinc (Zn) are trace elements
essential for normal spermatogenesis of mammals and play a critical role as antioxidant defense system enzymes. Se, Cu, and
Zn are associated with sperm quality in fertile and infertile men. However, there is little information about Se, Cu, and
Zn concentrations in semen in patients with varicocele and its association with seminal parameters. The purpose of this study
was to determine the concentrations of Se, Cu, and Zn in semen of patients with varicocele and the relationship with seminal
parameters. Total Reflection X-Ray Fluorescence was used for the fist time in the seminal fluid analysis. The concentration
of selenium in men with varicocele was smaller than the normozoospermic group, while no differences were observed for both
concentrations of zinc and copper. A significant positive correlation between zinc and selenium concentration was observed.
Selenium in seminal plasma correlates with a good spermatozoa concentrations, motility, and morphology. Additionally, a significant
positive correlation was observed between zinc levels and sperm count. In conclusion, a decrease in selenium concentration
was associated with detriment of seminal parameters. A study should be conducted to evaluate the benefits of both zinc and
selenium supplementation to improve seminal parameters in patients with varicocele. |
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