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1.
《Molecular & cellular proteomics : MCP》2018,17(12):2335-2346
Highlights
- •Quantitative metabolomics identified elevated lactate levels in diabetic brains.
- •Levels and enzymatic activity of LDH-A were also found significantly up-regulated.
- •GPR81 dependent PKA-CREB regulated cognition decline in the diabetic rats.
- •Mechanistic insights into role of lactate in diabetes-associated cognitive decline.
2.
《Molecular & cellular proteomics : MCP》2019,18(6):1085-1095
Highlights
- •Rapamycin and zinc induce moderate but significant mitochondrial proteome changes.
- •The mitochondrial proteins processing system is robust under subtoxic conditions.
- •Rapamycin and zinc perturb the mitochondrial proteins processing system.
- •Rapamycin and zinc perturb the mitochondrial proteins homeostasis.
3.
《Molecular & cellular proteomics : MCP》2019,18(2):294-307
Highlights
- •We studied mid-pregnancy alcohol exposure and baboon fetal cerebral artery.
- •238 proteins differed between control and alcohol-exposed fetuses near-term.
- •Proteins of metabolic pathways represented one of the major targets of alcohol.
- •Alcohol effect on the development of fetal brain vessels is persistent.
4.
5.
《Molecular & cellular proteomics : MCP》2019,18(12):2359-2372
Highlights
- •Nonenzymatically Ksu proteins shown different pattern from native cell Ksu proteins.
- •Motif preference of Ksu proteins was associated with different biological processes.
- •Up to 67 developing rice seeds proteins contain PTMs of Kac, Ksu, Kcr, Kmal, and Khib.
- •Some lysine residues of the key pathway enzymes are modified by succinylation.
6.
《Molecular & cellular proteomics : MCP》2019,18(6):1157-1170
Highlights
- •Auxin responsive proteins in Arabidopsis roots were identified from 3,514 detected proteins.
- •All six auxin receptors are stable in response to hormone via novel MRM assays.
- •The >100 differentially expressed proteins exhibit dynamic and transient responses to auxin.
- •Phenotypic screening of the top responsive proteins uncovered several novel root mutants.
7.
《Molecular & cellular proteomics : MCP》2018,17(11):2284-2296
Highlights
- •Pre-formed and offset gradients for high throughput, robustness and peptide re-focusing.
- •Minimal cross-contamination by disposable trap columns and partial elution.
- •Single shot DIA measurements achieve >5000 proteins in 21 min.
8.
《Molecular & cellular proteomics : MCP》2019,18(4):669-685
Highlights
- •quantitative phosphoproteome analysis of TDM-activated macrophages.
- •distinct Mincle-dependent and independent phosphorylation and gene regulations.
- •Mincle-dependent activation of PI3K/AKT signaling by TDM.
- •Mincle-independent macrophage response is linked to cell cycle regulation.
9.
《Molecular & cellular proteomics : MCP》2019,18(6):1123-1137
Highlights
- •Changes to the proteome of skin fibroblasts subjected to reductive stress have been quantitated.
- •Only a small set of proteins is selectively diminished upon exposure to reductants.
- •Collagens (COL1A2 and COL6A2) emerge as sentinels of reductive stress.
- •Reductive stress triggers receptor-independent Akt phosphorylation at Ser473.
10.
《Molecular & cellular proteomics : MCP》2018,17(12):2324-2334
Highlights
- •C9, GSN, PON1, and PON3 validated as serum biomarker candidates of EAC.
- •Multimarker panel with AUROC of 0.93 to aid current endoscopy surveillance of BE.
- •Induction of tissue C9 in BE, dysplastic BE and EAC.
- •Alteration of complement pathway glycoproteins during BE-EAC pathogenesis.
11.
《Molecular & cellular proteomics : MCP》2019,18(9):1796-1806
Highlights
- •iTRAQ-based analysis of saliva samples from oral cancer patients.
- •Proteome profiling of saliva samples from patients with oral premalignant lesions.
- •Verification of salivary biomarker candidates with MRM-MS and immunoassays.
- •Identification of salivary proteins as potential biomarkers of oral cancer.
12.
《Molecular & cellular proteomics : MCP》2019,18(10):1939-1949
Highlights
- •Proteome profiling of tissue interstitial fluids (TIFs) of oral cancer.
- •Pathway of aminoacyl tRNA biosynthesis enriched in proteome of TIFs.
- •Verification of nidogen-1 as a salivary biomarker of oral cancer.
- •High correlation between elevated tissue level of nidogen-1 and poor survival.
13.
《Molecular & cellular proteomics : MCP》2019,18(6):1110-1122
Highlights
- •Comprehensive analysis of inter-individual variation of normal urinary proteome.
- •Significant gender differences were observed.
- •Proteins increased in female urine are enriched in immunological pathways.
- •Estimated reference intervals of proteins as the baseline for biomarker discovery.
14.
《Molecular & cellular proteomics : MCP》2019,18(7):1345-1362
Highlights
- •Plant mitoribosomes contain several pentatricopeptide repeat proteins.
- •The small mitoribosomal subunit is of an exceptionally large size.
- •Protein units not directly related to translation may be attached to plant mitoribosomes to confer additional functions to these molecular machines.
15.
《Molecular & cellular proteomics : MCP》2018,17(12):2412-2433
Highlights
- •Proteogenomics and secretome comparison of human and zoonotic Staphylococcus aureus lineages.
- •869 secreted proteins identified in eight S. aureus isolates of CC8, CC22 and CC398.
- •CC398 lower secretion of surface proteins and higher secretion of hemolysins and exoenzymes.
- •Regulatory differences in the secretomes could be linked to lower SigB activity in CC398.
16.
Spatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation*
《Molecular & cellular proteomics : MCP》2019,18(5):909-922
Highlights
- •Characterization of the phagosomal proteome comparing resting and LPS-treated BMDCs.
- •Label-free quantification determined 2843 phagosomal proteins.
- •Reduced recruitment of hydrolases and V-ATPase to phagosomes of LPS-treated cells.
- •Increased recruitment of antigen cross-presentation molecules to these phagosomes.
17.
《Molecular & cellular proteomics : MCP》2019,18(2):245-262
Highlights
- •AP-DIA/SWATH analysis to identify TCTP-interacting proteins in NF1 tumor cells.
- •A highly specific TCTP–EF1A2 interaction but rather than TCTP–EF1A1 interaction.
- •TCTP–EF1A2 interaction mediating formation of EF1A2-elogation factor complex.
- •TCTP–EF1A2 dependent translation machinery regulating NF1 tumor cell growth.
18.
《Molecular & cellular proteomics : MCP》2019,18(7):1285-1306
Highlights
- •Identification of previously undetected chloroplast envelope proteins.
- •Up to date manual annotation of genuine (or shared) envelope components.
- •New hypotheses for localizations, functions, interactions among cell compartments.
- •A new resource of significant value to the broader plant science community.
19.
《Molecular & cellular proteomics : MCP》2018,17(11):2242-2255
Highlights
- •BioID and IP-MS were conducted to generate a global ZIKV-host protein interactome
- •Interactome consists of >3000 high confidence ZIKV-host protein interactions
- •Data mining indicates that ZIKV proteins interact with multiple host cell organelles
- •An important role for peroxisomes in ZIKV infection is uncovered
20.
《Molecular & cellular proteomics : MCP》2019,18(5):936-953
Highlights
- •In-depth proteome profiling of primary human myeloma cells
- •Characteristics of myeloma cells are related to hypoxic bone marrow conditions
- •Myeloma cells show specific immune evasion strategies
- •Metabolic adaptations involve tumor and stroma cells