首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Macrophage Phosphoproteome Analysis Reveals MINCLE-dependent and -independent Mycobacterial Cord Factor Signaling
Institution:3. From the 3Institute of Clinical Microbiology, Immunology and Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany;;4. Institute for Cell and Molecular Biosciences, University of Newcastle, Newcastle, UK;;5. Chair of Biochemistry, Department of Biology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany;;6. Center for Thrombosis and Hemostasis, Universitätsmedizin Mainz, Germany;;12. Department of Pharmacology and Experimental Therapy and Interfaculty Center of Pharmacogenomics and Drug Research, University of Tübingen;;8. Institute of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria;;9. Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, Unversity of Copenhagen, Denmark;;10. Department of Pharmacy, Faculty of Health and Medical Sciences, Unversity of Copenhagen, Denmark
Abstract:
  1. Download : Download high-res image (102KB)
  2. Download : Download full-size image
Highlights
  • ?quantitative phosphoproteome analysis of TDM-activated macrophages.
  • ?distinct Mincle-dependent and independent phosphorylation and gene regulations.
  • ?Mincle-dependent activation of PI3K/AKT signaling by TDM.
  • ?Mincle-independent macrophage response is linked to cell cycle regulation.
Keywords:Tuberculosis  RNA SEQ  Phosphoproteome  Signal Transduction*  Kinases*  C-type lectin receptor  macrophage  Mincle  mycobacteria  trehalose-6  6-diymcolate
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号