明目羊肝丸联合普拉洛芬滴眼液治疗围绝经期干眼症的临床研究

摘要 目的：探讨明目羊肝丸联合普拉洛芬滴眼液治疗围绝经期干眼症的临床疗效。方法：选取2019年7月至2020年8月在我院就诊的围绝经期干眼症患者103例206眼,根据随机数字表法将患者分为对照组（普拉洛芬滴眼液治疗）和实验组（对照组的基础上联合明目羊肝丸治疗）,分别为51例102眼和52例104眼,两组均治疗2个月。对比两组疗效、症状评分、泪液炎症因子、生存质量、Schirmer I试验（SIT）、泪膜破裂时间（BUT）、角膜荧光素染色（FL）评分及不良反应。结果：实验组治疗2个月后的临床总有效率优于对照组（P<0.05）。治疗2个月后,实验组眼干涩、视疲劳、异物感、灼热感症状评分、FL评分低于对照组（P<0.05）。治疗2个月后,实验组BUT、SIT高于对照组（P<0.05）。治疗2个月后,实验组泪液白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）水平低于对照组（P<0.05）。治疗2个月后,实验组心理健康、眼痛、社会活动、一般健康评分高于对照组（P<0.05）。两组治疗过程中均无明显不良反应。结论：明目羊肝丸联合普拉洛芬滴眼液治疗围绝经期干眼症,可改善患者症状和泪膜稳定性,降低泪液炎症因子水平,提高患者生存质量,安全有效。     

维生素A棕榈酸酯眼用凝胶联合聚乙烯醇滴眼液对干眼症患者泪液中 IL-1β与TNF-α水平的影响及其临床疗效

目的:探讨维生素A棕榈酸酯眼用凝胶联合聚乙烯醇滴眼液对干眼症患者泪液中IL-1β及临床疗效的影响。方法:选取2013年11月~2015年11月于我院治疗的干眼症患者60例,随机分为实验组和对照组,每组30例。对照组患者给予聚乙烯醇滴眼液治疗,实验组患者在对照组基础上加用维生素A棕榈酸酯眼用凝胶治疗。观察并比较两组患者治疗前后泪液中白细胞介素1β(IL-1β)、肿瘤坏死因子-α(TNF-α)水平、泪膜破裂时间(BUT)、泪液分泌试验(SIT)及角膜荧光素染色(FL)结果,以及临床总有效率。结果:与治疗前相比,两组患者治疗后泪液中IL-1β及TNF-α水平均降低,差异具有统计学意义(P0.05);与对照组相比,实验组患者治疗后泪液中IL-1β及TNF-α水平较低,差异具有统计学意义(P0.05);与治疗前比较,两组患者治疗后BUT及SIT评分均升高,而FL评分均降低,差异具有统计学意义(P0.05);与对照组相比,实验组患者治疗后BUT及SIT评分较高,而FL评分较低,差异具有统计学意义(P0.05);实验组临床总有效率高于对照组,差异具有统计学意义(P0.05)。结论:维生素A棕榈酸酯眼用凝胶联合聚乙烯醇滴眼液治疗干眼症积极有效,值得临床上大力推广。     

肿瘤坏死因子-α(TNF-α)和白细胞介素1β(IL-1β)在干眼症患者结膜上皮细胞和泪液中的表达及意义

目的:探讨肿瘤坏死因子-α(TNF-α)和白细胞介素-1β(IL-1β)在干眼症(DES)患者结膜上皮细胞和泪液中的表达及意义。方法:选择57例DES患者和50例健康者分别作为DES组和对照组,比较两组结膜上皮细胞和泪液中TNF-α、IL-1β基线值的差异,比较DES组治疗后结膜上皮细胞和泪液中TNF-α、IL-1β值与基线值的差异,治疗前后临床检查情况(泪膜破裂时间、泪液分泌试验、角膜荧光素染色),并对TNF-α、IL-1β表达和临床检查进行相关性分析。结果:DES组泪液、结膜上皮细胞中TNF-α、IL-1β表达均明显高于对照组(P0.05)。DES组治疗后泪液、结膜上皮细胞中TNF-α、IL-1β表达均较治疗前明显降低(P0.05)。与治疗前相比,DES患者治疗后泪膜破裂时间、泪液分泌试验、角膜荧光素染色等临床检查明显改善(P0.05)。TNF-α、IL-1β表达与泪膜破裂时间、泪液分泌试验呈负相关(P0.05),与角膜荧光素染色呈正相关(P0.05)。结论:DES患者泪液、结膜上皮细胞中TNF-α与IL-1β的表达上调,且与干眼症的病情进展密切相关,可为干眼症的临床诊断、治疗或预后提供参考。     

自体血清联合玻璃酸钠治疗白内障术后干眼症患者的效果

目的:研究自体血清联合玻璃酸钠治疗白内障术后干眼症患者的临床效果。方法:选择2015年1月～2018年12月我院收治的186例白内障术后干眼症患者,随机分为观察组以及对照组,每组各83例。对照组采用玻璃酸钠滴眼液治疗,观察组联合采用自体血清滴眼液治疗。连续给药4 w后,比较两组的治疗有效率,治疗前后的泪膜破裂试验和泪液分泌试验结果,泪液坏死因子(TNF)-α、白介素(IL)-6以及高敏C-反应蛋白(hs-CRP)水平的改变情况。结果:治疗后,观察组的有效率为95.18%(79/83),明显高于对照组[79.52%(66/83)](P0.05)。两组治疗后的泪膜破裂试验和泪液分泌试验结果均较治疗前明显改善(P0.05),且观察组的泪膜破裂试验和泪液分泌试验的改善程度明显优于对照组(P0.05);两组治疗后的泪液hs-CRP、TNF-α和IL-6水平均较治疗前明显降低,且观察组更少指标明显低于对照组(P0.05)。结论:自体血清联合玻璃酸钠对白内障术后干眼症患者的临床效果明显优于单用玻璃酸钠滴眼液,其可更有效增加泪膜的稳定性,减轻角膜损伤,减少泪液分泌,这可能与下调患者泪液中hs-CRP、TNF-α和IL-6水平有关。     

不同药物治疗白内障超声乳化术后干眼症的效果评价

目的研究不同药物治疗白内障超声乳化术后干眼症的疗效。方法将72例白内障超声乳化术后干眼症患者按随机数字表法分为两组各36例,观察组36例给予玻璃酸钠滴眼液治疗,对照组36例给予妥布霉素地塞米松眼膏治疗,观察比较两组患者的临床疗效。结果观察组患者术后干眼症症状评分与对照组相比明显降低,差异有统计学意义(P0.05)。观察组患者术后泪膜破裂时间(BUT)高于对照组、角膜荧光染色评分低于对照组,差异均有统计学意义(P0.05)。结论玻璃酸钠滴眼液治疗白内障超声乳化术后干眼症的效果显著,值得临床推广应用。     

杞菊地黄汤联合玻璃酸钠滴眼液对肝肾阴虚型干眼症患者眼表功能和泪液MMP-2、MMP-9水平的影响

摘要 目的：观察杞菊地黄汤联合玻璃酸钠滴眼液治疗肝肾阴虚型干眼症的疗效及对眼表功能和泪液基质金属蛋白酶-2（MMP-2）、基质金属蛋白酶-9（MMP-9）的影响。方法：病例来源于2018年6月~2021年3月期间就诊于湖南省直中医医院眼科门诊的干眼症患者,共98例。采用随机数字表法分为对照组和实验组,两组均49例。对照组给予玻璃酸钠滴眼液治疗,实验组在对照组基础上接受杞菊地黄汤治疗,两组均治疗4周。对比两组疗效、中医证候积分、眼表功能和泪液MMP-2、MMP-9水平变化,观察两组治疗期间不良反应发生率。结果：实验组的临床总有效率高于对照组（P<0.05）。实验组治疗4周后眼部干涩不爽、畏光、双目频眨、口干少津、白眼泛红、舌红、苔薄、脉细证候积分均低于对照组（P<0.05）。实验组治疗4周后角膜荧光素染色（FL）评分低于对照组,泪膜破裂时间（BUT）、泪液分泌试验（SIT）水平高于对照组（P<0.05）。实验组治疗4周后泪液MMP-2、MMP-9水平低于对照组（P<0.05）。两组间不良反应发生率无统计学差异（P＞0.05）。结论：杞菊地黄汤联合玻璃酸钠滴眼液治疗肝肾阴虚型干眼症,可促进患者症状缓解,改善眼表功能,降低泪液MMP-2、MMP-9水平,安全可靠。     

芪明颗粒的应用可改善T2DM患者眼科手术后干眼症

为探讨2型糖尿病(T2DM)患者超声乳化术后干眼并角膜上皮损伤患者应用芪明颗粒治疗的临床效果,本研究选取了80例病例患者(100眼)(2014年8月至2016年5月)进行研究,其中40例(50眼)采用普拉洛芬、玻璃酸钠滴眼液治疗(对照组)、40例患者在对照组基础上加用芪明颗粒治疗(观察组),对比两组效果。研究发现,治疗前,两组患者的泪膜破裂时间、5 min Schirmer值差异无统计学意义(p0.05);治疗后,观察组患者的泪膜破裂时间、5 min Schirmer值均显著的大于对照组(p0.05);治疗前,两组患者的角膜荧光素染色评分、结膜充血症状评分差异无统计学意义(p0.05);治疗后,观察组患者的角膜荧光素染色评分、结膜充血症状评分均显著的低于对照组(p0.05);治疗后,观察组患者的治愈58.00%、显效36.00%、有效6.00%,对照组治愈40.00%、显效38.00%、有效18.00%、无效4.00%,两组比较差异具有统计学意义(p0.05)。研究表明,T2DM患者超声乳化术后干眼并角膜上皮损伤患者应用芪明颗粒治疗能够进一步提升临床治疗效果,具备临床进一步推广应用的价值。     

玻璃体切割联合白内障手术治疗增殖性糖尿病视网膜病变中的疗效

目的:探讨玻璃体切割联合白内障手术治疗增殖性糖尿病视网膜病变的疗效。方法:选择2013年1月至2016年6月我院接诊的90例增殖性糖尿病视网膜病变患者,通过随机数表法分为观察组(n=45)和对照组(n=45)。对照组使用玻璃体切割术+晶状体切除术,观察组使用玻璃体切割术+超声乳化吸除术。比较两组最佳矫正视力、泪液白介素(IL)-2、角膜荧光素染色(FL)、泪膜破裂时间(BUT)以及泪液分泌试验(SIt)的结果以及并发症的发生情况。结果:手术后,观察组最佳矫正视力明显优于对照组(P0.05),泪液IL-2水平明显高于对照组(P0.05),FL显著低于对照组,BUT、SIt明显高于对照组(P0.05),囊膜浑浊、虹膜新生血管、角膜水肿、干眼症的发生率均显著低于对照组(P0.05)。结论:玻璃体切割联合超声乳化吸除术治疗增殖性糖尿病视网膜病变患者的效果显著,可促进术后视力恢复,改善泪液分泌,并减少并发症。     

全身化疗对实体恶性肿瘤患者眼表的影响

目的:研究初次全身化疗对恶性实体肿瘤患者眼表状态的影响.方法:选取首次化疗的恶性实体肿瘤的患者60例,年龄在50-75岁之间,在化疗前及化疗结束后1周分别进行眼表评估.检查内容包括:干眼相关症状问卷调查,泪膜破裂时间、基础泪液分泌试验、角膜荧光素染色、泪液羊齿状结晶、结膜丽丝胺绿染色、结膜印迹细胞学检查.结果:1)问卷调查提示全身化疗后,患者眼部出现视力波动、干涩、眼部不适等症状是最常见的;2)患者全身化疗后,眼表出现泪膜破裂时间缩短,基础泪液分泌量减少,结膜杯状细胞减少,角膜荧光素染色与结膜丽丝胺绿染色评分增加,泪液羊齿状结晶评级下降(P＜0.05).结论:全身化疗可对恶性肿瘤患者的眼表产生影响,能导致干眼病的发生和发展,因此在化疗的同时要关注患者眼表的健康,及时予以干预,提高患者的生存质量.     

重组bFGF滴眼液联合杞菊地黄丸对绝经后干眼症女性血清与泪液中 MMP-2及性激素水平的影响

目的:探讨重组b FGF滴眼液联合杞菊地黄丸对绝经后干眼症女性血清与泪液中MMP-2及性激素水平的影响。方法:收集我院收治的绝经后干眼症女性患者76例,随机分为对照组和实验组,每组38例。对照组患者给予重组牛碱性成纤维细胞生长因子滴眼液治疗,实验组在对照组基础上给予杞菊地黄丸治疗。观察并比较两组患者治疗前后血清以及泪液中E2、MMP-2水平。结果:与治疗前相比,两组患者治疗后血清以及泪液中E2水平均升高,而MMP-2水平均下降,差异具有统计学意义(P0.05);与对照组相比,实验组患者治疗后血清以及泪液中E2水平较高,而MMP-2水平较低,差异具有统计学意义(P0.05)。结论:重组b FGF滴眼液联合杞菊地黄丸能够升高绝经后干眼症女性血清与泪液中E2水平,降低MMP-2水平,对临床具有指导意义。     

翼状胬肉切除联合自体角膜缘干细胞移植术对翼状胬肉患者视觉质量和泪膜功能的影响

目的:探讨翼状胬肉切除联合自体角膜缘干细胞移植术治疗翼状胬肉的疗效及对视觉质量和泪膜功能的影响。方法:选取2017年2月～2018年12月期间我院收治的翼状胬肉患者201例,根据乱数表法将患者随机分为对照组(n=100)和研究组(n=101),对照组给予翼状胬肉切除术治疗,研究组在此基础上联合自体角膜缘干细胞移植术治疗。比较两组临床疗效、视觉质量、泪膜功能、并发症以及角膜上皮修复时间。结果:研究组术后6个月的临床总有效率为90.10%(91/101),显著高于对照组的73.00%(73/100)(P0.05)。研究组角膜上皮修复时间均短于对照组(P0.05)。两组术后6个月角膜散光度降低,且研究组低于对照组(P0.05);角膜水平曲度、角膜垂直曲度、视力、泪膜破裂时间(BUT)、基础泪液分泌试验(SIT)均升高,且研究组高于对照组(P0.05)。研究组随访期间并发症发生率低于对照组(P0.05)。结论:翼状胬肉患者在翼状胬肉切除术的基础上联合自体角膜缘干细胞移植术治疗,疗效确切,可有效改善患者的视觉质量和泪膜功能,并可减少术后并发症的发生率,临床应用价值较高。     

稳心颗粒对急性心肌梗死患者心率变异性及血清炎症因子水平的影响

目的:探讨稳心颗粒治疗急性心肌梗死性心律失常的疗效及对患者血清炎症因子水平的影响。方法:选择2013年6月-2016年6月在我院接受治疗的168例急性心肌梗死患者为研究对象,随机分为研究组和对照组,每组84例。对照组患者给予常规西药治疗,研究组患者在对照组基础上给予稳心颗粒口服治疗。观察并比较两组患者治疗前后心率变异性、每搏输出量(SV)、左心室射血分数(LVEF)、左心室舒张末径(LVEDD)、血清IL-6水平以及临床疗效。结果:与治疗前比较,两组患者治疗后SDNN,SDNN Index,SDANN,HF及LF均升高,而LF/HF值均降低,差异具有统计学意义(P0.05);与对照组比较,研究组患者治疗后SDNN,SDNN Index,SDANN,HF及LF较高,而LF/HF值较低,差异具有统计学意义(P0.05)。与治疗前比较,两组患者治疗后LVEF及SV均升高,而LVEDD均降低,差异具有统计学意义(P0.05);与对照组比较,研究组患者治疗后LVEF及SV较高,而LVEDD较低,差异具有统计学意义(P0.05)。与治疗前比较,两组患者治疗后血清IL-6水平均降低,差异具有统计学意义(P0.05);与对照组比较,研究组患者治疗后血清IL-6水平较低,差异具有统计学意义(P0.05)。研究组临床总有效率(91.7%)显著高于对照组(82.1%),差异具有统计学意义(P0.05)。结论:稳心颗粒治疗急性心肌梗死的临床疗效显著,不仅能够改善患者心律失常症状,还能降低血清炎症因子水平,值得临床进一步推广及应用。     

老年心肌梗死患者PCI术后心率变异性的变化及丹参滴丸的临床疗效研究

目的:探究老年心肌梗死患者经皮冠状动脉介入治疗(PCI)术后心率变异性的变化及实施PCI治疗后给予丹参滴丸的临床疗效。方法:收集2015年3月到2016年3月来我院就诊的老年急性心肌梗死患者56例,根据随机数字表法分为试验组及对照组,各28例,对所有患者实施PCI术,术后对照组使用基础药物治疗,试验组使用基础药物治疗联合复方丹参滴丸。比较PCI治疗前后心率变异性的变化及两组患者的心功能。结果:PCI术后,患者测定指标SDNN、SDNN Index及SDANN相对于术前均有升高(P0.05);频域分析指标HF及LF相对于术前均升高,LF/HF比值降低(P0.05)。治疗结束后,两组患者LVEF、SV及CI均明显升高,LVEDD明显降低(P0.05),与对照组相比,试验组患者LVEF、SV及CI较高,LVEDD较低(P0.05)。结论:PCI术能够改善老年心肌梗死患者心率变异性,而复方丹参滴丸对于PCI术后老年心肌梗死患者心功能指标均有明显改善,临床疗效较好。     

角膜接触镜辅助翼状胬肉切除术对患者泪膜功能及创面上皮愈合的影响

目的:研究角膜接触镜辅助翼状胬肉切除术对患者泪膜功能及创面上皮的影响。方法:选取2013年7月至2015年6月本院收治74例翼状胬肉切除术患者,根据入院顺序分为观察组和对照组,37例每组。观察组术后加用角膜接触镜,对照组术后使用常规纱布包盖。比较两组患者在术后1 d、5 d、10 d创面上皮愈合情况,术前和术后10 d泪膜功能情况。结果:术后10 d,观察组的Schimer Ⅰ试验、泪膜破裂时间显著长于对照组(P0.05)。术后1 d,观察组角膜上皮愈合率显著高于对照组(P0.05),术后5 d、10 d,观察组和对照组的角膜上皮愈合率比较无显著性差异(P0.05)。结论:角膜接触镜辅助翼状胬肉切除术能改善患者泪膜功能,促进患者创面上皮能在较短时间内恢复。     

Punctal plugs versus artificial tears for treating dry eye: a comparative observation of their effects on contrast sensitivity

This study aimed to compare the effects of treatment with punctal plugs versus artificial tears on visual function and tear film stability for dry eye. A total of 56 consecutive eyes of 28 dry eye patients observed at our clinic from May to October in 2009 were divided into two groups. One group (32 eyes of 16 patients) was treated with artificial tears, and punctal plugs were used in the other group (24 eyes of 12 patients). A questionnaire was used in these patients before treatment and was repeated 2 weeks after treatment. Fluorescent staining for tear film break-up time (BUT), the Schirmer test I (STI), and contrast sensitivity was performed at the same time. The questionnaire indicated that all patients complained about the uncomfortable symptoms associated with dry eye. These symptoms were relieved after the application of artificial tears or punctal plugs, and there was no significant difference between these two groups. We found that the corneal fluorescent staining disappeared after treatment. The BUT was improved significantly after treatment in both groups, but the improvement was greater in patients who received punctal plugs than those that received artificial tears. There was no remarkable change in the STI in the artificial tears group, but a significant change was observed in the punctal plugs group. The contrast sensitivities were greatly improved in simulated daylight, night, and glare disability conditions after treatment with artificial tears and punctal plugs. However, the changes in contrast sensitivity did not significantly differ between groups. Both artificial tears and punctal plugs relieved dry eye symptoms, repaired corneal lesions, enhanced tear film stability, and improved contrast sensitivity. Punctal plugs could improve tear film stability and elongate the BUT better than artificial tears.     

Early Changes in Ocular Surface and Tear Inflammatory Mediators after Small-Incision Lenticule Extraction and Femtosecond Laser-Assisted Laser In Situ Keratomileusis

Purpose

To characterize the early ocular-surface changes or tear inflammatory-mediators levels following small-incision lenticule extraction (ReLEx smile) and femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK).

Methods

Forty-seven myopic subjects were recruited for this prospective study. Fifteen underwent ReLEx smile and thirty-two underwent FS-LASIK. Corneal fluorescein (FL) staining, tear break-up time (TBUT), Schirmer I test (SIT), ocular surface disease index (OSDI) and central corneal sensitivity were evaluated in all participants. Tears were collected and analyzed for interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), nerve growth factor (NGF) and intercellular adhesion molecule-1 (ICAM-1) levels using multiplex magnetic beads. All measurements were preformed preoperatively and 1 day, 1 week, 1 month and 3 months postoperatively.

Results

FL scores in ReLEx smile group were lower than those of FS-LASIK group 1 week postoperatively (P = 0.010). Compared to the FS-LASIK group, longer TBUT were observed in ReLEx smile group 1 month (P = 0.029) and 3 months (P = 0.045) postoperatively. No significant differences were found in tear secretion for the two groups (P>0.05). OSDI scores were higher in FS-LASIK group 1 month after surgery (P = 0.020). Higher central corneal sensitivity was observed in ReLEx smile group 1 week, 1 month and 3 months (P<0.05) postoperatively. Compared to FS-LASIK group, lower and faster recovery of IL-6 and NGF levels in tears was observed in ReLEx smile group postoperatively (P<0.05). Tears TNF-α and ICAM-1 concentrations were not significantly different between the two groups at any follow-up time (P>0.05). Moreover, IL-6 and NGF levels correlated with ocular surface changes after ReLEx smile or FS-LASIK.

Conclusions

In the early postoperative period, ReLEx smile results in milder ocular surface changes than FS-LASIK. Furthermore, the tear inflammatory mediators IL-6 and NGF may play a crucial role in the ocular surface healing process following ReLEx smile and FS-LASIK.     

NF-kB 和TGF-beta1在超声乳化术治疗的白内障患者结膜上皮细胞中的表 达及其意义

目的：探讨NF-kB 和TGF-beta1 在超声乳化术治疗的白内障患者结膜上皮细胞中的表达及其意义。方法：选取我院眼科收治 的白内障患者24 例,共24 眼,且均接受超声乳化白内障摘除术和后房型人工晶状体植入术治疗。在治疗前和治疗后15天、30 天,采用免疫组织化学法检测患者结膜上皮细胞中NF-kB 和TGF-beta1 的表达,并进行泪液分泌试验、荧光素染色、泪膜破裂时间 和泪河高度测量四项检查。结果：NF-资B 和TGF-茁1 呈现先增强后减弱的趋势,与术前相比,术后15 天患者NF-kB 和TGF-beta1 染 色程度显著增强,差异具有统计学意义,(P<0.05);与术后15 天比较,术后30 天NF-kB 和TGF-beta1 染色程度减弱,差异具有统计 学意义,(P<0.05);与术前相比,术后15 天泪膜破裂时间较术前明显缩短,荧光素染色明显增强;与术前相比,术后30 天四项检查 结果无差异,P＞0.05。结论：超声乳化手术可提高白内障患者结膜上皮细胞中NF-kB 和TGF-beta1的表达,与术后眼膜的炎症反应 有关。     

Dry Eye Disease in Patients with Functioning Filtering Blebs after Trabeculectomy

Purpose

The aim of this study was to analyze dry eye disease (DED) in patients with functioning filtering blebs and to explore the relationship between the morphology of filtering blebs and ocular surface instability.

Methods

This was a cross-sectional, case-comparison study. Seventy glaucomatous patients (70 eyes) with functioning blebs who had undergone trabeculectomy more than 6 months prior (study group) and 35 control subjects (35 eyes) (control group) were included. All subjects completed an ocular symptom questionnaire that referred to the Shihpai Eye Study. Evaluation of meibomian gland obstruction, a tear film break-up time test (TFBUT), fluorescein corneal staining and a Schirmer’s tear test were then performed. Filtering bleb morphology was analyzed using Wuerzburg bleb classification scoring criteria in the study group. The presence of DED was defined as the concomitant presence of TFBUT <10 seconds and the presence of superficial punctate keratitis.

Results

The patients with functioning blebs presented higher corneal staining scores (P = 0.012) and lower TFBUT values (P = 0.043) than the control group. DED was present in 28/70 patients in the study group and 6/35 patients in the control group (P = 0.018). More patients in the study group complained of dryness (P = 0.001), a gritty or sandy sensation (P < 0.001) and redness (P = 0.048). In the study group, the patients with DED were significantly different from the patients without DED in both TFBUT (P < 0.001) and corneal staining (P < 0.001). More patients in the DED group were likely to report dryness (P = 0.013) and watery or teary eyes (P = 0.012). The differences in meibomian gland obstruction scores between the study and the control group, the DED and the non-DED group were not significant (P = 0.105 and P = 0.077, respectively). The values for microcysts and bleb heights were significantly higher in the DED group (P = 0.040 and P = 0.011, respectively). A Spearman’s rank correlation showed that microcysts were positively correlated with corneal staining (r = 0.270, P = 0.024). Bleb height was negatively correlated with TFBUT (r = -0.299, P = 0.012) and positively correlated with corneal staining (r = 0.275, P = 0.021). The relationships between DED and microcysts and between DED and bleb height were significant (r = 0.247, P = 0.039 and r = 0.307, P = 0.010, respectively).

Conclusion

DED is relatively common in patients with functioning filtering blebs following trabeculectomy. In DED patients, dryness and watery are common symptoms. Microcysts and bleb height are related to ocular surface instability and DED.