全文获取类型
收费全文 | 246414篇 |
免费 | 22747篇 |
国内免费 | 258篇 |
专业分类
269419篇 |
出版年
2018年 | 2649篇 |
2017年 | 2586篇 |
2016年 | 3443篇 |
2015年 | 3688篇 |
2014年 | 4611篇 |
2013年 | 6599篇 |
2012年 | 7287篇 |
2011年 | 7953篇 |
2010年 | 5421篇 |
2009年 | 4828篇 |
2008年 | 6932篇 |
2007年 | 7150篇 |
2006年 | 6761篇 |
2005年 | 6457篇 |
2004年 | 6373篇 |
2003年 | 6202篇 |
2002年 | 6053篇 |
2001年 | 12051篇 |
2000年 | 12011篇 |
1999年 | 9187篇 |
1998年 | 2693篇 |
1997年 | 2762篇 |
1996年 | 2711篇 |
1995年 | 2503篇 |
1994年 | 2442篇 |
1993年 | 2348篇 |
1992年 | 7220篇 |
1991年 | 7015篇 |
1990年 | 7088篇 |
1989年 | 6881篇 |
1988年 | 6393篇 |
1987年 | 6034篇 |
1986年 | 5381篇 |
1985年 | 5695篇 |
1984年 | 4489篇 |
1983年 | 3884篇 |
1982年 | 2688篇 |
1981年 | 2523篇 |
1980年 | 2329篇 |
1979年 | 4143篇 |
1978年 | 3160篇 |
1977年 | 2895篇 |
1976年 | 2856篇 |
1975年 | 3283篇 |
1974年 | 3513篇 |
1973年 | 3543篇 |
1972年 | 3077篇 |
1971年 | 2863篇 |
1970年 | 2543篇 |
1969年 | 2306篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
41.
L-myo-Inositol-1-phosphate synthase has been found to have at least a 5-fold preference for the beta-anomer of its natural substrate D-Glc-6-P. The alpha-anomer appears to be an inhibitor of the reaction and may be converted to product as well. As well as showing an enzymatic preference for the equatorial C-1 hydroxyl of D-Glc-6-P, our results suggest that it is the pyranose form of D-Glc-6-P that binds to the enzyme and that ring-opening is an enzymatic step. We have also found D-2-dGlc-6-P, D-2-F-2-dGlc-6-P, and D-Man-6-P each to be both competitive inhibitors and substrates that are converted to inositol phosphates by the synthase. D-Allose-6-P is a weak inhibitor of the enzyme, but not a substrate. D-Gal-6-P is neither substrate nor inhibitor. Thus the specificity of the synthase with respect to single position epimers of D-Glc-6-P increases in the order C1 less than C2 much less than C3 less than C4. 相似文献
42.
A L Nevmiatullin O N Vorob'eva A N Maianski? 《Zhurnal mikrobiologii, epidemiologii, i immunobiologii》1985,(7):67-71
The neutrophil-stimulating properties of 38 S. aureus strains and 32 S. epidermidis strains were studied in the reaction of luminol-mediated chemiluminescence. All S. aureus strains and 29 S. epidermidis strains were found to possess neutrophil-stimulating activity, the mean activity index for S. aureus being significantly higher. The stimulating activity of the strains varied within a wide range (the variation coefficient was 120.0 +/- 21.9%) and did not correlate with the content of protein A in bacterial cells and the degree of their hydrophoby. The opsonization of staphylococci with normal human serum enhanced the neutrophil reaction 1.5- to 100-fold and simultaneously leveled out the chemiluminescence indices in experiments with different strains (the variation coefficient was 8.0 +/- 1.5%). The nature of the neutrophil-stimulating effect of staphylococci and its relationship to the exploratory reactions of phagocytes are discussed. 相似文献
43.
N. I. Koshoridze N. G. Aleksidze N. B. Surguladze 《Journal of Evolutionary Biochemistry and Physiology》2003,39(4):446-450
Galactose- and inositol-binding proteins with lectin activity (GL-GAL and GL-I, respectively) were isolated from membranes enriched with cells of chicken brain fractions. Both lectins are glycoproteins of molecular mass 13.5 and 11.5 kDa, respectively; they show a high affinity to EDTA (GL-I) and EGTA (GL-GAL, GL-I), which indicates an important role of Ca+2 in molecular organization of these lectins. In brain glial cells of chick embryos, unlike adult chickens, a soluble form of lectins has been revealed; it is easily extracted with 2 mM EDTA and shows sensitivity to L-lactose, D-galactose, and N-acetyl-D-galactosamine. It is suggested that in the course of embryonal and postembryonal development of the chicken brain, a transformation and qualitative changes of the lectin spectrum occur due to a change of function of glial cells. 相似文献
44.
45.
46.
47.
48.
A rational attempt to prepare FmocHis(piTrt)OH regiospecifically gave in fact the well-known tau-trityl isomer, and experiments with model systems indicate that the prospects for access to pi-trityl histidine derivatives, which would be of great value for the racemization-free synthesis of histidine-containing peptides, are poor. 相似文献
49.
50.
N. P. Todaria 《Biologia Plantarum》1986,28(4):280-287
A comparative study of dark respiration and effects of high and low temperature on dark respiration in five greenhouse cultivated tropical and sub-tropical species was made. The respiration rates determined manometrically were low in all species. Respiration rates increased with increasing temperature. Low temperature treatment accelerated the rate of respiration at 25 °G except in two species. An attempt has been made to determine the critical and optimum temperature for these species. The respiratory behaviour of these species has been discussed with respect to their original habitats and prevailing environmental conditions. 相似文献