共查询到20条相似文献,搜索用时 31 毫秒
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Identification of upstream and intragenic regulatory elements that confer cell-type-restricted and differentiation-specific expression on the muscle creatine kinase gene. 总被引:66,自引:41,他引:25
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E A Sternberg G Spizz W M Perry D Vizard T Weil E N Olson 《Molecular and cellular biology》1988,8(7):2896-2909
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B-lymphocyte targeting of gene expression in transgenic mice with the immunoglobulin heavy-chain enhancer. 总被引:6,自引:2,他引:4
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P Gerlinger M LeMeur C Irrmann P Renard C Wasylyk B Wasylyk 《Nucleic acids research》1986,14(16):6565-6577
A hybrid gene containing rabbit beta-globin structural sequences (-9 to +1650), and a chicken conalbumin gene promoter (+62 to -102) in the place of the beta-globin promoter (upstream from -9), was inactive in 5 different transgenic mouse line. Adding the mouse immunoglobulin heavy-chain (IgH) enhancer to this construction specifically stimulated expression in B-cells. These results show that IgH enhancer is specifically active in B-cells. Expression of the hybrid gene was low compared to the endogenous immunoglobulin heavy and light-chain genes. Substituting the mouse immunoglobulin kappa light-chain gene (Ig kappa) promoter (+4 to -800) for the heterologous conalbumin promoter was not sufficient to restore gene expression to level of the endogenous genes. In addition to the reproducible B cell expression, we also found inheritable unexpected expression in certain tissues, which varied from line to line. 相似文献
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Characterization of human and mouse H19 regulatory sequences 总被引:1,自引:0,他引:1
Banet G Bibi O Matouk I Ayesh S Laster M Kimber KM Tykocinski M de Groot N Hochberg A Ohana P 《Molecular biology reports》2000,27(3):157-165
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Cioffi CC Middleton DL Wilson MR Miller NW Clem LW Warr GW 《The Journal of biological chemistry》2001,276(30):27825-27830
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Shamsher MK Chuzhanova NA Friedman B Scopes DA Alhaq A Millar DS Cooper DN Berg LP 《Human genetics》2000,107(5):458-465