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| 一个基于熵的精细定位数量性状位点的指数 | |
| 引用本文： | 向阳,李玉梅,刘再明,孙振球.一个基于熵的精细定位数量性状位点的指数[J].遗传学报,2007,34(4):373-380. |
| 作者姓名： | 向阳 李玉梅 刘再明 孙振球 |
| 作者单位： | 1. 中南大学数学学院,长沙,410081;怀化学院数学系,怀化,418008 2. 中南大学公共卫生学院,长沙,410078;怀化学院数学系,怀化,418008 3. 中南大学数学学院,长沙,410081 4. 中南大学公共卫生学院,长沙,410078 |
| 基金项目： | This work was supported by Scientific Research Fund of Huaihua University and the National Natural Foundation of China (No.10371133). |
| 摘 要： | 针对数量性状位点的精细定位,本文采用群体的极端样本,利用稠密的标记位点,通过比较标记的熵和条件熵,给出了一个基于熵的指数。该指数是标记基因和性状位点间连锁不平衡系数的函数,它不依赖于标记基因的频率。该指数对应我们之前提出的数量性状位点精细定位的哈迪-温伯格不平衡(HWD)指数,但在精细定位数量性状位点时,本文提出的指数的效能要高于哈迪-温伯格不平衡(HWD)指数。通过计算机模拟,文章调查了不同遗传参数下该指数的性质。模拟结果表明该指数用作精细定位是有效的。 |
| 关 键 词： | 精细定位 数量性状 熵 基于熵的指数 |
| 收稿时间： | 16 June 2006 |
| 修稿时间： | 2006-06-16 |
An Entropy-based Index for Fine-scale Mapping of QTL |
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| Yang Xiang,Yumei Li,Zaiming Liu,Zhenqiu Sun.An Entropy-based Index for Fine-scale Mapping of QTL[J].Journal of Genetics and Genomics,2007,34(4):373-380. | |
| Authors: | Yang Xiang Yumei Li Zaiming Liu Zhenqiu Sun |
| Institution: | 1. College of Mathematics, Central South University, Changsha 410081, China; 2. School of Public Health, Central South University, Changsha 410078, China; 3. Mathematics Department of Huaihua College, Huaihua 418000, China |
| Abstract: | By comparing the entropy and conditional entropy in a marker, an entropy-based index for fine-scale linkage-disequilibrium gene mapping is presented using high-density marker maps in extreme samples for quantitative trait. The entropy-based index is the function of LD between the marker and the trait locus and does not depend on marker allele frequencies across the loci. It is parallel to Hardy-Weinberg disequilibrium (HWD) measure for QTL fine mapping, but its power of fine mapping QTL is higher than that of HWD measure. Through simulations, the fine mapping performance of this entropy-based index is investigated extensively under various genetic parameters. The results show that the indices presented here are both robust and powerful. |
| Keywords: | entropy entropy-based Index QTL fine mapping |
| 本文献已被 CNKI 维普 万方数据 ScienceDirect 等数据库收录！ | |