Rat brain monoamine and serotonin S2 receptor changes during pregnancy |
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Authors: | Jonathan Glaser Vivienne Ann Russell Anna Susanna de Villiers Johanna Anita Searson Joshua Joachim Fransua Taljaard |
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Institution: | (1) MRC Research Unit for the Neurochemistry of Mental Diseases, Department of Chemical Pathology, University of Stellenbosch, Tygerberg Hospital, P. O. Box 113, 7505 Tygerberg, (R.S.A.) |
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Abstract: | The concentrations of noradrenaline (NA), dopamine (DA), serotonin (5-HT), and their metabolites were determined in 5 brain areas of non-pregnant, 15 and 20 day pregnant and 4 day post-partum rats. Striatal 5-HT content was significantly lower in 15 and 20 day pregnant rats than in estrous controls. A significant decrease in striatal and frontal cortex 5-hydroxyindole-3-acetic acid (5-HIAA) concentration was observed in 15 day pregnant rats. Significant increases in hypothalamic and hippocampal NA levels were observed at 4 days post-partum. Frontal cortex serotonin S2 receptorKd was reduced in 4 day post-partum rats. There was no significant change in S2 receptorB
max during pregnancy. Levels of progesterone were negatively correlated with striatal DA, homovanillic acid (HVA), 5-HT, and 5-HIAA levels, hypothalamic DA, hippocampal 5-HT, and frontal cortex 5-HIAA values as well as striatal HVA to DA, and HVA to 3,4-dihydroxyphenylacetic acid (DOPAC) ratios and amygdaloid HVA to DOPAC ratios. The limbic neurotransmitter changes might possibly contribute to mood changes which occur during pregnancy and post-partum. |
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Keywords: | Dopamine noradrenaline serotonin S2 receptors progesterone estradiol-17" target="_blank">gif" alt="beta" align="MIDDLE" BORDER="0"> corticosterone limbic system pregnancy |
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