| 锌离子对配体门控型离子通道的调节作用 |
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| 引用本文： | 孙焱,张雅婷,梁培基.锌离子对配体门控型离子通道的调节作用[J].生物物理学报,2010(12). |
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| 作者姓名： | 孙焱 张雅婷 梁培基 |
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| 作者单位： | 上海交通大学生命科学技术学院生物医学工程系; |
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| 基金项目： | 国家自然科学基金项目(30870836); 上海交通大学分析测试中心资助项目~~ |
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| 摘 要： | 在中枢神经系统(central nervous system,CNS)中,锌离子对配体门控型离子通道具有重要的调节作用。锌离子随着神经元的活动从突触前膜的囊泡中释放到突触间隙,对突触内受体进行调控。锌离子抑制N-甲基-D-天冬氨酸(N-methyl-D-aspartate,NMDA)型谷氨酸受体的活性,而对非NMDA型谷氨酸受体的调控具有多样性。由γ氨基丁酸(γ-aminobutyric acid,GABA)受体所介导的抑制性突触传递活动也受到锌离子的抑制;而锌离子对glycine受体则呈现出浓度依赖的双向调节效应。病理条件下,锌离子参与了兴奋性细胞毒作用所触发的神经元凋亡过程。本文主要阐述了在CNS中,锌离子对配体门控型离子通道所介导的突触传递活动的调控作用,以及这些调控作用的生理功能和病理意义。
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| 关 键 词： | 锌离子 配体门控型离子通道 兴奋性细胞毒作用 海马 视网膜 |
Zinc Modulation of Ligand-Gated Ion Channels |
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| SUN Yan,ZHANG Yating,LIANG Peiji.Zinc Modulation of Ligand-Gated Ion Channels[J].Acta Biophysica Sinica,2010(12). |
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| Authors: | SUN Yan ZHANG Yating LIANG Peiji |
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| Institution: | SUN Yan,ZHANG Yating,LIANG Peiji Department of Biomedical Engineering,School of Life Sciences and Biotechnology,Shanghai Jiao Tong University,Shanghai 200240,China |
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| Abstract: | In the central nervous system(CNS),zinc has a modulatory role of the ligand-gated ion channels. This divalent cation is released from presynaptic vesicles into the synaptic cleft upon neuronal activity and acts as a modulator of many ligand-gated ion channels.The NMDA-type glutamate receptors are inhibited by zinc,whereas non-NMDA type glutamate receptors appear to be differently affected.Furthermore,inhibitory transmission mediated via GABA receptors could be suppressed by zinc;however,zinc may bidirection... |
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| Keywords: | Zinc Ligand-gated ion channels Excitotoxicity Hippocampus Retina |
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