| Survivin在肺鳞癌、腺癌中的表达及其与Ki67和p53表达的关系 |
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| 引用本文： | 刘树立,姜波.Survivin在肺鳞癌、腺癌中的表达及其与Ki67和p53表达的关系[J].中国组织化学与细胞化学杂志,2008,17(6). |
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| 作者姓名： | 刘树立 姜波 |
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| 作者单位： | 1. 中国医科大学基础医学院病理学教研室,中国医科大学第一临床学院病理科,沈阳110001
2. 辽宁省清源满族自治县人民医院病理室,辽宁,113300 |
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| 摘 要： | 目的探讨survivin在肺鳞癌、腺癌中的表达和意义及其与Ki67、p53表达的相关性。方法采用免疫组织化学SP法检测survivin、Ki67和p53在112例肺鳞癌、腺癌中的表达情况。结果Survivin、Ki67和p53的阳性率分别为59．8％（67／112）、46．4％（52／112）和51．8％（58／112），survivin的表达与肺癌的低分化（P=0．009）和淋巴结转移正相关（P=0．014）；Ki67和p53的表达分别与肺鳞癌、腺癌的低分化程度负相关（P〈0．05）。Survivin与Ki67和p53在肺鳞癌、腺癌中的表达分别正相关（P〈0．01）。结论Survivin的表达与肺鳞癌、腺癌的低分化和淋巴结转移正相关；Ki67和p53的表达分别与肺鳞癌和腺癌的低分化程度相关，survivin、Ki67和p53三者的协同表达可能是促进肺癌的恶性进展的重要因素。
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| 关 键 词： | 肺癌 免疫组化 |
EXPRESSIONS AND CORRELATIONS OF SURVIVIN,Ki67 AND p53 IN LUNG SQUAMOUS CELL CARCINOMAS AND ADENOCARCINOMAS |
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| Liu Shuli,Jiang Bo.EXPRESSIONS AND CORRELATIONS OF SURVIVIN,Ki67 AND p53 IN LUNG SQUAMOUS CELL CARCINOMAS AND ADENOCARCINOMAS[J].Chinese Journal of Histochemistry and Cytochemistry,2008,17(6). |
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| Authors: | Liu Shuli Jiang Bo |
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| Institution: | Liu Shuli1,Jiang Bo2(1Department of Pathology,College of Basic Medical Sciences, Department of Pathology,The First Clinical College,China Medical University,Shenyang,110001,2The People\'s Hospital,Manchu Autonomous County of Qingyuan,Liaoning 113300,China) |
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| Abstract: | Objective To explore the expressions and correlations of survivin,Ki67 and p53 in lung squamous cell carcinomas and adenocarcinomas.Methods The expressions of survivin,Ki67 and p53 were examined in 112 cases of lung squamous cell carcinomas and adenocarcinomas using immunohistochemical S-P method.Results The positive expression rate of survivin,Ki67 or p53 was 59.8%(67/112),46.4%(52/112)or 51.8%(58/112)respectively.The expression of survivin were positively associated with the poor differentiation(P=0.009)a... |
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| Keywords: | Survivin Ki67 p53 |
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