| S-100及CD83在溃疡性结肠炎患者结肠黏膜的表达 |
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| 引用本文： | 李娜,张晓岚,赵东强,刘蕾,房澍名,姚金锋,冯丽英.S-100及CD83在溃疡性结肠炎患者结肠黏膜的表达[J].中国组织化学与细胞化学杂志,2009,18(6):657-661. |
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| 作者姓名： | 李娜 张晓岚 赵东强 刘蕾 房澍名 姚金锋 冯丽英 |
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| 作者单位： | 1. 河北医科大学第二医院消化内科,河北省消化病重点实验室,河北省消化病研究所,河北,石家庄,050000;北京军区总医院消化内科,北京,100700
2. 河北医科大学第二医院消化内科,河北省消化病重点实验室,河北省消化病研究所,河北,石家庄,050000 |
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| 基金项目： | 河北省科技厅资助项目，河北省普通高校强势特色学科专项经费部分资助 |
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| 摘 要： | 目的通过检测溃疡性结肠炎（UC）患者结肠黏膜S-100及CD83的表达,探讨其与UC临床活动度、内镜分级的关系。方法取47例UC患者结肠黏膜标本根据内镜及临床活动度进行分级,同时收集正常对照者结肠黏膜标本13例,应用免疫组织化学法检测S-100及CD83在UC患者结肠黏膜的表达水平。结果正常对照组结肠黏膜固有层S-100及CD83弱表达,且二者在UC患者结肠黏膜的阳性细胞数及染色强度,与正常对照组比较差异显著（P〈0.01）,并且有随病变分级的加重逐渐增加的趋势。结论未成熟及成熟树突状细胞（Dendritic Cells DCs）均参与UC的发生。与正常对照组相比UC患者结肠黏膜固有层中S-100及CD83表达上调,在一定程度上反映了疾病的活动度。
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| 关 键 词： | 溃疡性结肠炎 树突状细胞 S-100 CD83 |
EXPRESSION OF S-100 AND CD83 IN COLONIC MUCOSA OF PATIENTS WITH ULCERATIVE COLITIS |
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| Li Na,Zhang Xiaolan,Zhao Dongqiang,Liu Lei,Fang Shuming,Yao Jinfeng,Feng Liying.EXPRESSION OF S-100 AND CD83 IN COLONIC MUCOSA OF PATIENTS WITH ULCERATIVE COLITIS[J].Chinese Journal of Histochemistry and Cytochemistry,2009,18(6):657-661. |
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| Authors: | Li Na Zhang Xiaolan Zhao Dongqiang Liu Lei Fang Shuming Yao Jinfeng Feng Liying |
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| Institution: | Li Na1,2,Zhang Xiaolan1,Zhao Dongqiang1,Liu Lei1,Fang Shuming1,Yao Jinfeng1,Feng Liying1(1Department of Gastrology,The Second Hospital of Hebei Medical University,Hebei Key Laboratory of Gastroenterology,Hebei Institute of Gastroenterology,Shijiazhuang 050000,China,2Department of Gastrology,General Hospital of Beijing Military Area,Beijing 100700,China) |
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| Abstract: | Objective To investigate the expression of S-100 and CD83 in colonic mucosa of patients with UC and analyze their correlations with clinical and endoscopic activity.MethodsForty-seven UC patients and thirteen normal controls were collected.Immunohistochemistry(IHC) was employed to study the disposition of DCs with markers of S-100 and CD83 in colonic mucosa.ResultsIn normal controls,positive cells were detected.The expression of both S-100 and CD83 was detected in a great quantity and stronger staining dens... |
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| Keywords: | S-100 CD83 Ulcerative Colitis Dendritic cells S-100 CD83 |
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