| 吸入一氧化碳对肢体严重缺血/再灌注损伤及其所致休克的影响 |
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| 作者姓名： | Zhao J Shi ZL Qi WZ Zhu ZL |
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| 作者单位： | 河北医科大学解剖学教研室;河北医科大学附属第一医院病理科; |
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| 基金项目： | 河北省自然科学基金资助项目(C2005000729) |
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| 摘 要： | 目的：观察吸入适量一氧化碳（CO）对肢体严重缺血/再灌注（I/R）损伤及其所致休克的影响。方法：SD大鼠36只,随机分为I/RI、/R吸入CO（RC）及假手术（S）组。用夹闭双侧股动脉及绑扎后肢根部的办法使后肢缺血8 h,之后行再灌注12 h1、0 d,以此建立肢体严重I/R损伤模型。RC组于再灌注前2 h时开始持续吸入含有CO的医用空气6 h（CO的体积分数为0.075%）,S、I/R组呼吸自然空气。观测对比尾动脉压（CAP）、10 d存活率及肢体损伤指标的变化。结果：I/R组再灌注后CAP快速下降,再灌注至8 h时CAP均值降为（5.3259±0.3832）kPa;RC组CAP下降较I/R组速率慢、幅度小,再灌注至8 h时CAP均值为（8.3300±0.4224）kPa。I/R组用于10 d存活率观察的8只大鼠,于再灌注13~20 h间全部死亡,RC组8只中有1只死亡,其余7只再灌注10 d时仍存活。与I/R组比较,RC组肢体的病理学表现明显减轻,肢体湿干重比值、血清乳酸脱氢酶和肌酸激酶活性显著下降（P〈0.05）。结论：吸入适量CO对肢体严重I/R损伤所引起的血压下降有反向调节作用,可有效防止休克的发生,减轻肢体损伤,显著提高动物的存活率。
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| 关 键 词： | 大鼠 肢体 缺血 再灌注损伤 一氧化碳 |
Effects of carbon monoxide inhalation on severe limb ischemia/reperfusion injury and its damages lead to shock |
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| Zhao J,Shi ZL,Qi WZ,Zhu ZL.Effects of carbon monoxide inhalation on severe limb ischemia/reperfusion injury and its damages lead to shock[J].Chinese Journal of Applied Physiology,2011,27(2):149-153. |
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| Authors: | Zhao Jin Shi Zhong-Li Qi Wan-Zheng Zhu Zhen-Long |
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| Institution: | ZHAO Jin1,SHI Zhong-li1,QI Wan-zheng1,ZHU Zhen-long2(1.Department of Anatomy,2.The First Affiliated Hospital,Hebei Medical University,Shijiazhuang 050017,China) |
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| Abstract: | Objective:To study the protective effect of carbon monoxide(CO) inhalation on the serious limb ischemia/reperfusion(I/R) injury,and which effects caused to shock in rats.Methods:36 SD rats were randomly divided into I/R,I/R + CO(RC),sham operation(S) groups.I/R injury models were made by the occlusion of the femoral artery for 8 h and the reperfusion for 12 h,10 d.Before reperfusion of 2 h,RC group started to breathe medical air containing CO(the volume fraction of CO:0.075%) continuously,until after reperf... |
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| Keywords: | rat limb ischemia reperfusion injury carbon monoxide |
| 本文献已被 CNKI 维普 PubMed 等数据库收录！ |
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