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| 内生真菌产紫杉醇研究的回顾与展望 | |
| 引用本文： | 康冀川,靳瑞,文庭池,何劲,雷邦星.内生真菌产紫杉醇研究的回顾与展望[J].菌物学报,2011,30(2):168-179. |
| 作者姓名： | 康冀川 靳瑞 文庭池 何劲 雷邦星 |
| 作者单位： | 1. 贵州大学西南药用生物资源教育部工程研究中心,贵阳,550025;贵州大学贵州省生化工程中心,贵阳,550025;贵州大学贵州省农业生物工程重点实验室,贵阳,550025 2. 贵州大学贵州省农业生物工程重点实验室,贵阳,550025;贵州大学生命科学学院,贵阳,550025 3. 贵州大学西南药用生物资源教育部工程研究中心,贵阳,550025;贵州大学贵州省生化工程中心,贵阳,550025 4. 贵州大学西南药用生物资源教育部工程研究中心,贵阳,550025;贵州大学贵州省农业生物工程重点实验室,贵阳,550025 |
| 基金项目： | 贵州大学创新基金[红豆杉产紫杉醇及其类似物内生真菌的研究（校研农2010006）] |
| 摘 要： | 紫杉醇是一种高效、低毒、广谱的天然抗癌药物,是人类未来20年间最有效的抗癌药物之一。近年来的研究发现,从植物内生真菌中发酵生产紫杉醇被证明是解决药源问题的有效途径。本文概述了微生物发酵生产紫杉醇的研究进展,包括产紫杉醇内生真菌的分离、多样性和真菌产紫杉醇的优势,紫杉醇的提取和检测技术,同时对如何提高内生真菌紫杉醇产量进行了比较全面的综述。随着现代分子生物学技术和微生物发酵工程的发展,工业上大规模发酵生产紫杉醇将有望实现。 |
| 关 键 词： | 紫杉醇 内生真菌 生物多样性 发酵工程 |
Recent research advances on endophytic fungi producing taxol |
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| Authors: | KANG Ji-Chuan JIN Rui WEN Ting-Chi HE Jing and LEI Bang-Xing |
| Institution: | The Engineering and Research Center for Southwest Bio-Pharmaceutical Resources of Normal Education Ministry of China, Guizhou University, Guiyang 550025, China Guizhou Biochem-engineering Research Center, Guizhou University, Guiyang 550025, China Guizhou Key Laboratory of Agricultural Bioengineering, Guizhou University, Guiyang 550025, China;Guizhou Key Laboratory of Agricultural Bioengineering, Guizhou University, Guiyang 550025, China College of Life Science, Guizhou University, Guiyang 550025, China;The Engineering and Research Center for Southwest Bio-Pharmaceutical Resources of Normal Education Ministry of China, Guizhou University, Guiyang 550025, China Guizhou Biochem-engineering Research Center, Guizhou University, Guiyang 550025, China;The Engineering and Research Center for Southwest Bio-Pharmaceutical Resources of Normal Education Ministry of China, Guizhou University, Guiyang 550025, China Guizhou Key Laboratory of Agricultural Bioengineering, Guizhou University, Guiyang 550025, China;The Engineering and Research Center for Southwest Bio-Pharmaceutical Resources of Normal Education Ministry of China, Guizhou University, Guiyang 550025, China Guizhou Biochem-engineering Research Center, Guizhou University, Guiyang 550025, China |
| Abstract: | Taxol with high efficiency, low toxicity and broad-spectrum is one of the most effective natural anti-cancer drugs for the coming 20 years. Recent studies have found that taxol from the fermentation of endophytic fungi of plants has been demonstrated a high potential for efficient production of taxol. Summarize recent research advances in the technique of fermentation producing taxol including biodiversity of taxol-producing endophytic fungi, isolation of the fungi, and the techniques of taxol extraction. The pathways to improve the production of taxol by endophytic fungal were also comprehensively discussed. Along with the development of molecular biology techniques and fermentation engineering, the large-scale fermentation to produce taxol is hopefully realizable. |
| Keywords: | taxol endophytic fungi biodiversity fermentation engineering |
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