| 孤雌活化诱导恢复的小鼠减数分裂期间细胞骨架的动态与作用 |
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| 引用本文： | 朱子玉,文端成,韩之明,雷蕾,刘忠华,寇朝辉,徐营,王敏康,陈大元.孤雌活化诱导恢复的小鼠减数分裂期间细胞骨架的动态与作用[J].生物化学与生物物理进展,2003,30(5):819-823. |
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| 作者姓名： | 朱子玉 文端成 韩之明 雷蕾 刘忠华 寇朝辉 徐营 王敏康 陈大元 |
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| 作者单位： | 1. 中国科学院动物研究所生殖生物学国家重点实验室,北京,100080;苏州大学生命科学学院,苏州,215006
2. 中国科学院动物研究所生殖生物学国家重点实验室,北京,100080 |
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| 基金项目： | 国家自然科学基金资助项目（39360028）. |
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| 摘 要： | 减数分裂的顺利完成是胞质分裂和核分裂在时间和空间上的协调结果，细胞骨架系统在减数分裂的一系列事件中具有重要的调节作用.实验通过孤雌活化诱导小鼠MⅡ期卵减数分裂恢复，采用激光共聚焦显微术检测了减数分裂期间的微管、微丝和核的动态变化，并通过细胞骨架药物处理，以分析微管和微丝在减数分裂事件中的不同作用.结果显示：纺锤体微管为核的定位、分离和运动所必需；纺锤体从与质膜平行旋转至与质膜垂直是极体排放的前提；微丝是控制纺锤体旋转的关键因素；纺锤体旋转完成后微丝随即解聚，不参与极体的最后排出，形成原核后再重新组装.
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| 关 键 词： | 卵母细胞，减数分裂，纺锤体，微管，微丝，孤雌活化 |
| 收稿时间： | 2003/3/28 0:00:00 |
| 修稿时间： | 6/5/2003 12:00:00 AM |
The Dynamics and Functions of Cytoskeleton During Meiotic Resumption Induced by Parthenogenetic Activation in Mouse Oocytes |
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| ZHU Zi-Yu,WEN Duan-Cheng,HAN Zhi-Ming,LEI Lei,LIU Zhong-Hu,KOU Zhao-Hui,XU Ying,WANG Min-Kang and CHEN Da-Yuan.The Dynamics and Functions of Cytoskeleton During Meiotic Resumption Induced by Parthenogenetic Activation in Mouse Oocytes[J].Progress In Biochemistry and Biophysics,2003,30(5):819-823. |
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| Authors: | ZHU Zi-Yu WEN Duan-Cheng HAN Zhi-Ming LEI Lei LIU Zhong-Hu KOU Zhao-Hui XU Ying WANG Min-Kang and CHEN Da-Yuan |
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| Institution: | State Key Laboratory of Reproductive Biology, Institute of Zoology, The Chinese Academy of Sciences, Beijing 100080, China;College of Life Science, Suzhou University, Suzhou 215006, China;State Key Laboratory of Reproductive Biology, Institute of Zoology, The Chinese Academy of Sciences, Beijing 100080, China;State Key Laboratory of Reproductive Biology, Institute of Zoology, The Chinese Academy of Sciences, Beijing 100080, China;State Key Laboratory of Reproductive Biology, Institute of Zoology, The Chinese Academy of Sciences, Beijing 100080, China;State Key Laboratory of Reproductive Biology, Institute of Zoology, The Chinese Academy of Sciences, Beijing 100080, China;State Key Laboratory of Reproductive Biology, Institute of Zoology, The Chinese Academy of Sciences, Beijing 100080, China;State Key Laboratory of Reproductive Biology, Institute of Zoology, The Chinese Academy of Sciences, Beijing 100080, China;State Key Laboratory of Reproductive Biology, Institute of Zoology, The Chinese Academy of Sciences, Beijing 100080, China;State Key Laboratory of Reproductive Biology, Institute of Zoology, The Chinese Academy of Sciences, Beijing 100080, China |
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| Abstract: | |
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| Keywords: | oocyte meiosis spindle microtubule microfilament parthenogenetic activation |
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