| 供体细胞的选择与动物克隆效率研究进展 |
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| 引用本文： | 毕春明,文端成,陈大元.供体细胞的选择与动物克隆效率研究进展[J].生物化学与生物物理进展,2003,30(4):518-521. |
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| 作者姓名： | 毕春明 文端成 陈大元 |
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| 作者单位： | 中国科学院动物研究所,计划生育生殖生物学国家重点实验室,北京,100080 |
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| 基金项目： | 科技部攀登专项（95-专-08）和中国科学院知识创新工程重大项目（KSCX1-05-01）. |
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| 摘 要： | 哺乳动物体细胞克隆经过几年的发展，已取得了很大进展.已有多种细胞被采用并得到了克隆后代.但动物克隆效率仍然很低，供体细胞的选择是动物克隆中的重要步骤.供体细胞的细胞周期、细胞类型、细胞来源和分化程度等方面都可能影响动物克隆的效率.
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| 关 键 词： | 核移植，动物克隆，供体细胞，细胞周期，细胞类型，克隆效率 |
| 收稿时间： | 2003/1/20 0:00:00 |
| 修稿时间： | 2003年1月20日 |
Advances in Donor Cell Selection and Efficiency of Animal Cloning |
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| BI Chun-Ming,WEN Duan-Cheng and CHEN Da-Yuan.Advances in Donor Cell Selection and Efficiency of Animal Cloning[J].Progress In Biochemistry and Biophysics,2003,30(4):518-521. |
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| Authors: | BI Chun-Ming WEN Duan-Cheng and CHEN Da-Yuan |
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| Institution: | State Key Laboratory of Reproductive Biology, Institute of Zoology,The Chinese Academy of Sciences, Beijing 100080, China;State Key Laboratory of Reproductive Biology, Institute of Zoology,The Chinese Academy of Sciences, Beijing 100080, China;State Key Laboratory of Reproductive Biology, Institute of Zoology,The Chinese Academy of Sciences, Beijing 100080, China |
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| Abstract: | Although much progress has been achieved in the last few years, mammalian cloning is still inefficient. Donor cell selection is critical for the success of cloning animal, and it is also an important factor affecting the cloning efficiency. The progress of cloning animal using donor cells of different cell cycle, cell type, cell resource and cell differentiation degree has been summarized. |
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| Keywords: | nuclear transfer mammal clone donor cell cell cycle cell type cloning efficiency |
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