Tuning cellular responses to BMP-2 with material surfaces |
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| Institution: | 1. Department of Clinical Dentistry, Center for Clinical Dental Research, University of Bergen, Norway;2. Department of Cranio-Maxillofacial and Oral Surgery, Medical University of Innsbruck, Innsbruck, Austria;3. Department of Fibre and Polymer Technology, Royal Institute of Technology, KTH, Stockholm, Sweden;4. Department of Biomedicine, University of Bergen, Norway;5. Chair Tissue Engineering and Regenerative Medicine, University Hospital of Würzburg, Germany;6. Fraunhofer Project Group Regenerative Technologies in Oncology, Würzburg, Germany;7. Department of Clinical Science, University of Bergen, Bergen, Norway;8. DiaCoating GmbH, Innsbruck, Austria;9. Institute of Organic Chemistry, University of Würzburg, Würzburg, Germany;1. School of Bioscience and Engineering, Jadavpur University, Kolkata 700032, India;2. Department of Veterinary Surgery, Radiology West Bengal University of Animal and Fishery Sciences, Kolkata 700037, India;3. Bioceramics and Coating Division, CSIR-Central Glass and Ceramic Research Institute, Kolkata 700032, India;4. Department of Mechanical Engineering, Jadavpur University, Kolkata 700032, India |
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| Abstract: | Bone morphogenetic protein 2 (BMP-2) has been known for decades as a strong osteoinductive factor and for clinical applications is combined solely with collagen as carrier material. The growing concerns regarding side effects and the importance of BMP-2 in several developmental and physiological processes have raised the need to improve the design of materials by controlling BMP-2 presentation. Inspired by the natural cell environment, new material surfaces have been engineered and tailored to provide both physical and chemical cues that regulate BMP-2 activity. Here we describe surfaces designed to present BMP-2 to cells in a spatially and temporally controlled manner. This is achieved by trapping BMP-2 using physicochemical interactions, either covalently grafted or combined with other extracellular matrix components. In the near future, we anticipate that material science and biology will integrate and further develop tools for in vitro studies and potentially bring some of them toward in vivo applications. |
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| Keywords: | BMP-2 Material surface Cell adhesion Growth factor immobilization BMP receptors Signaling |
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