| 基于人免疫缺陷病毒-1的慢病毒载体系统研究进展 |
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| 引用本文： | 高强,刘珠果,陈红星,邓继先.基于人免疫缺陷病毒-1的慢病毒载体系统研究进展[J].生物技术通讯,2007,18(1):122-124. |
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| 作者姓名： | 高强 刘珠果 陈红星 邓继先 |
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| 作者单位： | 1. 沈阳药科大学,制药工程学院,辽宁,沈阳,110016
2. 军事医学科学院,生物工程研究所,北京,100071 |
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| 摘 要： | 慢病毒能够感染分裂细胞和非分裂细胞,因而被发展成为重要的转基因载体。慢病毒载体已经发展到了第三代,其安全性已经大为提高。经过结构优化的慢病毒载体已经用于转基因动物生产和基因治疗研究,而稳定包装细胞系的建立使得慢病毒的生产更为简便。
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| 关 键 词： | 慢病毒载体 生物安全性 包装细胞系 转基因动物 基因治疗 |
| 文章编号： | 1009-0002（2007）01-0122-03 |
| 修稿时间： | 2006-05-25 |
Development of Lentivirus Vector System Based on HIV-1 |
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| GAO Qiang,LIU Zhu-guo,CHEN Hong-xing,DENG Ji-xian.Development of Lentivirus Vector System Based on HIV-1[J].Letters in Biotechnology,2007,18(1):122-124. |
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| Authors: | GAO Qiang LIU Zhu-guo CHEN Hong-xing DENG Ji-xian |
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| Institution: | 1. Department of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016; 2. Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071; China |
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| Abstract: | Lentivirus can be developed as an important transgenic vector because it can infect dividing cells and non-dividing cells. Safety of the lentivirus vector are improved especially a vector named as the third generation lentivirus vector, which had been applied to transgenic animals and gene therapy research. Stable packaging cell lines were developed, which make production of lentivirus vector convenient. |
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| Keywords: | lentivirus vector bio-safety packaging cell line transgenic animals gene therapy |
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