An essential role for glucocorticoid in casein gene expression in rat mammary explants |
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| Authors: | J K Kulski Y J Topper P Chomczynski P Qasba |
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| Institution: | 1. Laboratory of Biochemistry and Metabolism National Institutes of Arthritis, Diabetes, and Digestive and Kidney Diseases National Institutes of Health, Bethesda, Maryland 20205 USA;2. Laboratory of Pathophysiology, National Cancer Institute, Bethesda, MD 20205 USA |
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| Abstract: | It is demonstrated that the accumulation of 42 K casein mRNA in mammary tissue from adrenalectomized, virgin rats is almost 20x higher in the presence of exogenous hydrocortisone than in its absence. Accumulation of 25 K casein mRNA in this tissue is totally dependent on the steroid. The results indicate a much greater dependency on hydrocortisone than was appreciated previously, and also show that this dependency does not reflect a loss of cell viability in the absence of the steroid. |
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| Keywords: | I insulin F hydrocortisone P prolactin casein mRNA Adrex adrenalectomized |
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