| 地塞米松与硫酸镁对大鼠小肠缺血再灌注损伤的作用及机制 |
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| 引用本文： | 陈亚彬,陈士达,陈素珊,徐佳,彭优,张俊隆,黄应雄,谈智,周利君,姚巧玲.地塞米松与硫酸镁对大鼠小肠缺血再灌注损伤的作用及机制[J].中国实验动物学报,2008,16(6):445-448. |
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| 作者姓名： | 陈亚彬 陈士达 陈素珊 徐佳 彭优 张俊隆 黄应雄 谈智 周利君 姚巧玲 |
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| 作者单位： | 中山大学中山医学院,广州,510080 |
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| 基金项目： | 中山大学学生暑期科研项目
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| 摘 要： | 目的研究地塞米松和硫酸镁对大鼠小肠缺血再灌注（I/R）损伤的保护作用,并初步探讨其机制。方法制作小肠I/R模型,实验分为假手术阴性对照组、I/R组、硫酸镁治疗组、地塞米松治疗组、地塞米松和硫酸镁联合治疗组,比较五组血浆二胺氧化酶（DAO）、丙二醛（MDA）的含量,同时比较小肠的病理切片观察治疗效果。结果①I/R组小肠组织病理变化明显,血浆DAO、MDA比假手术阴性对照组显著升高;②硫酸镁治疗组和地塞米松治疗组小肠病理变化减轻,血浆DAO、MDA比I/R组显著降低,且两组无显著差别;③硫酸镁和地塞米松合用组的血浆MDA比I/R组显著升高,但是小肠病理变化和I/R组相比无明显区别,血浆DAO也和I/R组无明显差别。结论硫酸镁,地塞米松分别对大鼠小肠缺血再灌注有保护作用而二者合用却无明显的保护作用。
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| 关 键 词： | 地塞米松 硫酸镁 小肠缺血再灌注 |
Protective Effects and Mechanism of Magnesium Sulfate and Dexamethasone against Ischemia-Reperfusion Injury of the Small Intestine in SD Rats |
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| CHEN Ya-bin,CHEN Shi-da,CHEN Su-shan,XU Jia,PENG You,ZHANG Jun-long,HUANG Ying-xiong,TAN Zhi,ZHOU Li-jun,YAO Qiao-ling.Protective Effects and Mechanism of Magnesium Sulfate and Dexamethasone against Ischemia-Reperfusion Injury of the Small Intestine in SD Rats[J].Acta Laboratorium Animalis Scientia Sinica,2008,16(6):445-448. |
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| Authors: | CHEN Ya-bin CHEN Shi-da CHEN Su-shan XU Jia PENG You ZHANG Jun-long HUANG Ying-xiong TAN Zhi ZHOU Li-jun YAO Qiao-ling |
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| Institution: | CHEN Ya-bin,CHEN Shi-da,CHEN Su-shan,XU Jia,PENG You,ZHANG Jun-long,HUANG Ying-xiong,TAN Zhi,ZHOU Li-jun,YAO Qiao-ling(Zhongshan School of Medicine of Sun Yat-sen University,Guangzhou 510080,China) |
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| Abstract: | Objective To evaluate the effects of magnesium sulfate and dexamethasone against ischemia-reperfusion injury of the small intestine in SD rats,and explore the mechanism.Methods\ Rat model of small intestine I/R injury was used.The SD rats were divided into five groups randomly: sham operation group,ischemia-reperfusion group,magnesium sulfate group,dexamethasone group,and magnesium sulfate plus dexamethasone group.The plasma contents of malondialdehyde(MDA),the activity of diamine oxidase(DAO) in plasma wer... |
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| Keywords: | Dexamethasone Magnesium sulfate Ischemia-reperfusion injury Rat |
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