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Recombination of repeat elements generates somatic complexity in human genomes
Institution:1. RIKEN Center for Integrative Medical Sciences (IMS), Yokohama 230-0045, Japan;2. Institute for Protein Research, Osaka University, Osaka 565-0871, Japan;3. Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa 277-8562, Chiba, Japan;4. Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA;5. Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm 171 77, Sweden;6. Stockholm University, Frescativägen, 114 19 Stockholm, Sweden;7. Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm 171 77, Sweden;8. Science for Life Laboratory, Tomtebodavägen 23, 171 65 Solna, Sweden;9. Department of Neuropathology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology (TMGHIG), Tokyo 173-0015, Japan;10. Central RNA Laboratory and Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia (IIT), Genova 16163, Italy;11. Artificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo 135-0064, Japan;12. Graduate School of Frontier Sciences, University of Tokyo, Chiba 277-8562, Japan;13. Computational Bio Big-Data Open Innovation Laboratory (CBBD-OIL), AIST, Tokyo 135-0064, Japan;14. Human Technopole, Milan 20157, Italy
Abstract:
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Keywords:Alu  L1  recombination  somatic mosaicism  structural variants  NAHR  non-allelic homologous recombination  repeat elements
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