| 奈替米星发酵放大工艺研究 |
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| 引用本文： | 杨丽, 王莲芬,.奈替米星发酵放大工艺研究[J].微生物学通报,2000,27(5):356-359. |
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| 作者姓名： | 杨丽 王莲芬 |
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| 作者单位： | 1. 青岛化工学院,青岛,266042
2. 青岛大学,青岛,266071 |
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| 摘 要： | 考察了奈替米星摇瓶发酵代谢特征，研究了磷酸盐和甲硫氨酸对菌丝生长和发酵单位的促进与提高作用。进而，以相同单位体积搅拌功率为基准放大，使１５ｔ发酵罐奈替木星发酵过程接近摇瓶水平。
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| 关 键 词： | 奈替米星 发酵 放大 |
| 文章编号： | 0253-2654(2000)05-0356-04 |
| 修稿时间： | 1999-05-02 |
STUDIES ON SCALE-UP OF NETILMICIN FERMENTATION TECHNOLOGY |
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| YANG Li,WANG Lian-Fen.STUDIES ON SCALE-UP OF NETILMICIN FERMENTATION TECHNOLOGY[J].Microbiology,2000,27(5):356-359. |
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| Authors: | YANG Li WANG Lian-Fen |
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| Institution: | YANG Li
;(Qingdao Institute of Chemical Technolog, Qingdao 266042);WANG Lian-Fen
;(Qingdao University, Qingdao 266071) |
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| Abstract: | Netilmicin n etabolic characteristics of shaking-flask fermentation were investigated. In 12L glass fermentor, it was showed that phosphate and methionine stimulated growth of mycelia and increased the production of antibiotic.On this basis, netilmicin fermentation had been scaled up successfully according to the standard of the same agitated power per unit volume from 12L fermentor to 5t fermentor. |
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| Keywords: | Netilmicin Fermentation Scale-up |
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