氟哌啶醇与奥氮平治疗精神分裂症的疗效对比探究

目的：对比分析氟哌啶醇与奥氮平治疗精神分裂症的临床疗效。方法：回顾性分析我院2008年4月-2011年12月收治的精神分裂症患者62例,通过随机数法将其分为两组,其中31例为氟哌啶醇组,剩余31例为奥氮平组,比较两组服药后的临床疗效以及药物不良反应情况。结果：6周后氟哌啶醇组和奥氮平组的PANSS总分均明显低于治疗前PANSS总分,组间比较,治疗3周、6周后奥氮平组PANSS总分均低于氟哌啶醇组,并且同时段奥氮平组的减分率明显高于氟哌啶醇组,差异均具有统计学意义（P〈0.05）。氟哌啶醇组的心电图异常例数和静坐不能例数明显高于奥氮平组,差异均具有统计学意义。而氟哌啶醇组不良反应发生率为48.39%,奥氮平组不良反应发生率为51.61%,差异无统计学意义。奥氮平组治疗6周后TG含量明显高于治疗前,并且两组的BMI也明显高于治疗前,差异均具有统计学意义（P〈0.05）。结论：氟哌啶醇与奥氮平在治疗精神分裂症上均有较好疗效,不良反应发生率也相似,而奥氮平改善症状较好,同时对心脏影响小,但是比氟哌啶醇易引起TG和BMI的增高,临床上需要根据患者身体条件选择药物,提高其安全性。

Comparison of Haloperidol and Olanzapine in Schizophrenia

Objective： To compare clinical efficacy of haloperidol and olanzapine in the treatment of schizophrenia. Methods： A retrospective analysis of hospital in April 2008-2011 in December were 62 cases of patients with schizophrenia, by random number be divided into two groups, 31 cases haloperidol group, the remaining 31 cases olanzapine group, two groups were compared after taking the clinical efficacy and adverse drug reactions. Results： After 6 weeks haloperidol and olanzapine groups PANSS total scores were lower than the pre-treatment PANSS total score between the two groups, three weeks of treatment, six weeks after olanzapine group PANSS total scores were lower than haloperidol group, and at the same time the reduction rate of the segment olanzapine group was higher than the haloperidol group, the differences were statistically significant （P 〈0.05）. Olanzapine group was higher than the haloperidol group ECG abnormal cases and akathisia numbers of cases, the differences were statistically significant. Haloperidol adverse incidence of 48.39% and the olanzapine group adverse reaction rate was 51.61%, the difference was not statistically significant. TG content was higher than the olanzapine group after 6 weeks of treatment before treatment, and two groups of BMI was higher than before treatment, the differences were statistically significant （P 〈0.05）. Conclusion： Haloperidol and olanzapine in the treatment of schizophrenia have a better effect, the incidence of adverse reactions similar olanzapine improve symptoms better, while smaller impact on the heart, but more than haloperidol cause increased TG and BMI, a clinical need for the drug of choice, according to the patient＇s physical condition and improve their security.