小剂量快速注射丙泊酚在胃镜检查中的安全有效性分析

目的：观察小剂量快速注射丙泊酚在无痛胃镜检查中的安全性及有效性，观察该方法对患者识记能力的影响。方法：选择60例行无痛胃镜检查的患者，随机分成A组和B组。所有患者均给予1μg／kg芬太尼。给予芬太尼后1分钟后，A组患者按照5mg／sec的速度给予2mg／kg丙泊酚；B组患者按照20mg／sec的速度给予1mg／kg丙泊酚。患者睫毛反射消失后进行胃镜检查。记录患者基础时及麻醉过程中不同时点的收缩压、舒张压、心率以及脉搏血氧饱和度，记录患者失去意识时间、胃镜检查时间、患者苏醒时间，记录检查过程中有无呛咳、体动，记录患者有无术中知晓，记录患者检查后一周内的有无识记能力的减退。结果：两组患者基本情况无统计学差异；60例患者无一例出现术中知晓；两组患者在麻醉过程中不同时点的循环情况及脉搏血氧饱和度之间没有统计学差异；检查过程中呛咳、体动的发生率组间比较无统计学差异；失去意识时间和苏醒时间组间比较P≤0．05，具有统计学差异；检查后一周内，识记能力减退发生率组间比较具有统计学差异。结论：快速注射小剂量丙泊酚可以保证患者安全、满足无痛胃镜检查的需要，同时可以降低丙泊酚的用量，减少药物蓄积，减少丙泊酚所致的识记功能减退。

Analysis of the Efficacy and Safety on Fast-infusion Propofol in Painless Gastrofiberscopy

Objective： To evaluate the efficacy and safety of fast-infusion propofol applied to anesthesia of painless gastrofibers- copy, and to observe the incidence rate of postoperative cognition dysfunction. Methods： Sixty patients scheduled for painless gastroscopy were randomly divided into group A and B. All patients were given fentanil 1 ~g/kg intravenously, one minute later, propofol 2 mg/kg was injected intravenously at the speed of 5mg/s in group A and propofol 1 mg/kg at the speed of 20mg/s in group B. Gastrofiberscopy was inserted after eyelashes reflex had been extinct. The blood pressure ,heart rate and the spo2 at different time point were recorded; The time of loss of consciousness, revival time and the examine time were recorded; irritating cough and body movement were recorded. Results： There are no significant differences in group A and B between the basic statements, none of the sixty patients has unpleasant memory during the gastrofiberscopy examination. There are no significant differences in group A and B between the circulation and spo2. There are no differences in group A and B between irritating cough and body movement. The time of losing of consciousness and revival time are different between the two groups. The incidence rate of postoperative cognition dysfunction is different between the two groups. Conclusions： Fast-infusion propofol applied to anesthesia of painless gastrofiberscopy was safe and effective in anesthesia of painless gastroflberscopy, this method can help to reduce adverse reaction ofpropol, and to reduce the incidence rate of postoperative cognition dysfunction resulting from propofol.