| 双孔钾通道TASK-1的研究进展 |
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| 引用本文： | 董学海,肖骏,李先涛.双孔钾通道TASK-1的研究进展[J].生物磁学,2011(19):3790-3793. |
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| 作者姓名： | 董学海 肖骏 李先涛 |
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| 作者单位： | [1]三峡大学医学院,湖北宜昌443002 [2]华中科技大学附属同济医院骨科,湖北武汉430030 |
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| 基金项目： | 湖北省卫生厅青年科技人才基金（QJX2008-5） |
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| 摘 要： | 双孔钾离子通道是一种背景钾离子通道，广泛分布于各种兴奋和非兴奋细胞中，并具有许多重要的生理功能。TASK-1是双孔钾离子通道家族的重要一员，它对缺氧和细胞外酸化敏感，参与形成心肌动作电住平台期，调节呼吸、肺动脉平滑肌收缩和醛固酮的分泌，并且是麻醉剂的作用靶点，人们不断对其进行研究并取得了很多重要结果，本文将概述双孔钾通道TASK-1的研究进展。
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| 关 键 词： | 双孔钾离子通道 TASK-1 功能 |
Research progress of K2P channel TASK- 1 |
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| DONG Xue-hai,XIAO Jun,LI Xian-tao.Research progress of K2P channel TASK- 1[J].Biomagnetism,2011(19):3790-3793. |
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| Authors: | DONG Xue-hai XIAO Jun LI Xian-tao |
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| Institution: | 1 Medical School of Sanxia University, Yichang, 443002, China; 2 Department of Orthopedics, TongjiHospital, Huazhong University of Science and Technology, Wuhan, 430030, China) |
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| Abstract: | The two-pore domain potassium channel （K2P） is a background channel, which is widely distributed in excited and unexcited cells, and plays important physiological roles in those cells. TASK-1 channel is a member of K2P family and sensitive to hypoxia and extracelinlar acidosis. The acid-sensitive channel substantially contributes to the outward current flowing in the plateau range of action potentials. TASK- 1 channel may determine the contractile and electrophysiological properties of pulmonary artery smooth muscle. It also regulates respiration and secretion of aldosterone and is a target of anesthetics. Background TASK-1 channel was deeply investigated by researcher and lots of data were accumulated. The review described recent research progress of K2P channel TASK-1. |
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| Keywords: | K2P channel TASK-1 Functions |
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