Antioxidative and prooxidative effects of quercetin on A549 cells |
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Authors: | Robaszkiewicz Agnieszka Balcerczyk Aneta Bartosz Grzegorz |
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Institution: | 1. Department of Molecular Biophysics, University of Łódź, Banacha 12/16, 90-237 Łódź, Poland;2. Department of Biochemistry and Cell Biology, University of Rzeszów, Cegielniana 12, 35-959 Rzeszów, Poland |
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Abstract: | Quercetin, a common plant polyphenol, has been reported to show both antioxidant and prooxidant properties. We studied the effects of quercetin on A549 cells in in vitro culture. We found that low concentrations of the flavonoid stimulated cell proliferation and increased total antioxidant capacity (TAC) of the cells; while higher concentrations of the flavonoid decreased cell survival and viability, thiol content, TAC and activities of superoxide dismutase, catalase and glutathione S-transferase. Quercetin decreased production of reactive oxygen species in the cells but produced peroxides in the medium. The cellular effects of quercetin are therefore complex and include both antioxidant effects and induction of oxidative stress due to formation of reactive oxygen species in the extracellular medium. |
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Keywords: | Quercetin Reactive oxygen species Glutathione Superoxide dismutase Catalase Glutathione S‐transferase |
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