| 哺乳动物睾丸细胞间连接的动态调控 |
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| 引用本文： | 蒋洪涛,梁芳,邵佇雄,朱宝长.哺乳动物睾丸细胞间连接的动态调控[J].细胞生物学杂志,2011(4). |
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| 作者姓名： | 蒋洪涛 梁芳 邵佇雄 朱宝长 |
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| 作者单位： | 首都师范大学生命科学学院; |
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| 基金项目： | 国家自然科学基金(No.30870934)资助项目~~ |
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| 摘 要： | 精子的发生过程是一个受多种因素(包括由细胞间连接的动态变化所形成的微环境等)精确调控的过程。细胞因子及睾酮以自分泌、旁分泌的形式对该微环境中的细胞连接水平如:生殖细胞穿越血睾屏障(the blood-testis barrier,BTB)的开闭机制等进行调控,从而对精子的发生起到重要调节作用。本文讨论了各种因素对细胞间连接的自分泌、旁分泌调控方式的影响,并简要介绍了近腔细胞外质特化(apical ectoplasmic specialization,近腔ES)-BTB-半桥粒/基底膜功能调控轴模型在生精细胞穿越BTB及精子释放等生精过程中的作用,为人们进一步认识精子发生过程中细胞间联系的功能及其调控提供了新的视角。
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| 关 键 词： | 睾丸细胞连接 细胞因子 睾酮 自分泌 旁分泌 |
The Regulation of Cell Junction Dynamics in the Mammalian Testis |
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| Hong-Tao Jiang,Fang Liang,Zhu-Xiong Shao,Bao-Chang Zhu.The Regulation of Cell Junction Dynamics in the Mammalian Testis[J].Chinese Journal of Cell Biology,2011(4). |
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| Authors: | Hong-Tao Jiang Fang Liang Zhu-Xiong Shao Bao-Chang Zhu |
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| Institution: | Hong-Tao Jiang,Fang Liang,Zhu-Xiong Shao,Bao-Chang Zhu~* (College of Life Science,Capital Normal University,Beijing 100048,China) |
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| Abstract: | Spermatogenesis is a complex biochemical event,including dynamic change of cell junctions. This review illustrated the effects of cytokines and testosterone on cell junctions in the microenvironment of germ cell via paracrine regulation,including the maintaining of BTB and the moving of germ cell from basal compartment to apical compartment.The intricate role of cytokines and testosterone in regulating the transit of primary spermatocytes through the BTB has been discussed.We described herein an apical ES-B... |
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| Keywords: | testicular cell junctions cytokines testosterone autocrine paracrine |
| 本文献已被 CNKI 等数据库收录！ |
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