| 氟西汀与三氯生复合暴露对麦穗鱼的毒性效应 |
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| 引用本文： | 闫亮,穆磊,陈红星,郭忠宝,罗永巨,谢凌天.氟西汀与三氯生复合暴露对麦穗鱼的毒性效应[J].应用生态学报,2018,29(9):3058-3066. |
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| 作者姓名： | 闫亮 穆磊 陈红星 郭忠宝 罗永巨 谢凌天 |
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| 作者单位： | 1.中国科学院沈阳应用生态研究所污染生态与环境工程重点实验室, 沈阳 110016;2.中国科学院大学, 北京 100049;3.华南师范大学环境研究院环境理论化学教育部重点实验室, 广州 510006;4.广西水产科学研究院, 南宁 530021 |
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| 基金项目： | 本文由国家自然科学基金项目(31270549)和中国科学院百人计划项目(Y2SBR111SS)资助 |
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| 摘 要： | 为探讨药品和个人护理产品(PPCPs)复合污染对水生生态系统的影响,本试验以东北地区土著鱼类麦穗鱼为试验材料,研究了氟西汀(FLX)与三氯生(TCS)复合暴露对其不同器官的毒性效应.经急性(4 h)与慢性(42 d)复合暴露试验后分别检测麦穗鱼Ⅰ相和Ⅱ相解毒酶、神经系统、消化系统及抗氧化系统等受到的影响.结果表明: 在FLX/TCS复合暴露条件下,麦穗鱼脑部乙酰胆碱酯酶活性受到短暂抑制,肝中细胞色素P450活性持续受到抑制,肠中α-葡萄糖苷酶活性在急性暴露后受到诱导但是长期暴露后被抑制,同时长期复合暴露导致肝中脂质过氧化水平升高.氟西汀和三氯生对麦穗鱼的复合暴露可对麦穗鱼多个器官产生急性毒性应激效应,而随着暴露时间的延长,麦穗鱼可产生一定的适应性,但这种适应作用的机制有待进一步研究.
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| 收稿时间： | 2017-12-27 |
Combined effects of fluoxetine and triclosan on Pseudorasbora parva. |
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| YAN Liang,MU Lei,CHEN Hong-xing,GUO Zhong-bao,LUO Yong-ju,XIE Ling-tian.Combined effects of fluoxetine and triclosan on Pseudorasbora parva.[J].Chinese Journal of Applied Ecology,2018,29(9):3058-3066. |
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| Authors: | YAN Liang MU Lei CHEN Hong-xing GUO Zhong-bao LUO Yong-ju XIE Ling-tian |
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| Institution: | 1.Key Laboratory of Pollution Ecology and Environmental Engineering, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China;2.University of Chinese Academy of Sciences, Beijing 100049, China;3.Ministry of Education Key Laboratory of Theoretical Chemistry of Environment, Environmental Research Institute, South China Normal University, Guangzhou 510006, China;4.Guangxi Aca-demy of Fishery Sciences, Nanning 530021, China. |
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| Abstract: | We examined the effects of binary mixture of two different pharmaceutical and personal care products (PPCPs) on aquatic organisms. The topmouth gudgeon Pseudorasbora parva, native to northeast China, was used to study the combined effects of fluoxetine (FLX) and triclosan (TCS) on its different organs. After acute (4 h) and chronic (42 d) treatments, the combined effects of FLX/TCS on phase I and phase II detoxification enzymes, nervous system, digestive system and antioxidant system were evaluated. The results showed that the AChE activity in the brain of P. parva was transiently inhibited, whereas the activity of EROD in the liver was continuously inhi-bited. The activity of α-Glu in the intestine was induced after acute exposure but was inhibited after chronic exposure. Meanwhile, the level of lipid peroxidation in the liver was elevated after chronic exposure. In conclusion, the mixture of fluoxetine and triclosan produced toxic effects on multiple organs of P. parva, which could be alleviated after prolonged exposure, indicating an acclimation. However, the mechanisms of this acclimation needed further study. |
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