| Gβ类似蛋白-WDR26对细胞增殖的影响 |
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| 引用本文： | 朱传炳,曾伟奇,朱莹,李大力,袁婺洲,王跃群,李永青,梁宋平,吴秀山.Gβ类似蛋白-WDR26对细胞增殖的影响[J].生命科学研究,2006,10(2):123-127. |
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| 作者姓名： | 朱传炳 曾伟奇 朱莹 李大力 袁婺洲 王跃群 李永青 梁宋平 吴秀山 |
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| 作者单位： | 湖南师范大学,生命科学学院,蛋白质化学与发育生物学教育部重点实验室,中国,湖南,长沙,410081 |
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| 基金项目： | 国家高技术研究发展计划(863计划);国家研究发展基金;教育部长江学者奖励计划;浙江省湖州市自然科学基金 |
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| 摘 要： | WD40重复序列蛋白是一类结构保守、功能复杂的蛋白．关于此类蛋白和细胞内信号传导途径的研究显示，该家族成员很可能通过调控胞内信号转导而影响细胞基本生命活动．在此前的研究中，我们报道了一个新基因WD40 repeat protein26的克隆．其初步研究结果显示WDR26蛋白与MAPK信号途径的负调控相关．在最近的研究中，我们构建了稳定转染pCMV—WDR26表达载体的HeLa细胞系，结果显示WDR26蛋白在HeLa细胞系中的过度表达，能够促进细胞分裂，加快细胞的倍增速度．因此，WDR26很可能具有通过MAPK信号途径调节细胞增殖的功能．
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| 关 键 词： | WDR26蛋白 MAPK信号途径 细胞增殖 |
| 文章编号： | 1007-7847(2006)02-0123-05 |
| 收稿时间： | 2006-03-10 |
| 修稿时间： | 2006-04-29 |
G-β-like Protein,WDR26 is Involved in Cell Proliferation |
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| ZHU Chuan-bing,ZENG Wei-qi,ZHU Ying,LI Da-li,YUAN Wu-zhou,WANG Yue-qun,LI Yong-qing,LIANG Song-ping,WU Xiu-shan.G-β-like Protein,WDR26 is Involved in Cell Proliferation[J].Life Science Research,2006,10(2):123-127. |
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| Authors: | ZHU Chuan-bing ZENG Wei-qi ZHU Ying LI Da-li YUAN Wu-zhou WANG Yue-qun LI Yong-qing LIANG Song-ping WU Xiu-shan |
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| Institution: | Key Lab for Development Biology and Protein Chemistry, College of Life Sciences, Hunan Normal University, Changsha 410081, Hunan, China |
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| Abstract: | WD40 repeat proteins belong to a protein family of conserved structure and complex cellular functions. Previous studies show that some family members have effect on primary cellular process by regulating certain signaling pathway. In earlier study, we reported the cloning of a new gene, which encodes for WD40 repeat protein 26 and showed that it is involved in the negative regulation of MAPK signaling pathway. In this study, we constructed a stable transfected HeLa cell line with pCMV-WDR26, and found that the over-expression of WDR26 promoted cell division and accelerated the proliferation speed. These results suggest that WDR26 can probably regulate cell proliferation through MAPK signaling pathway. |
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| Keywords: | protein 26 MAPK signaling pathway cell proliferation |
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